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29 Current news of Indiana University

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Researchers develop blood test for depression, bipolar disorder

13-Apr-2021

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and ...

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Breakthrough in the production of three-dimensional molecular structures

New dimensions in organic chemistry through light-mediated synthesis

07-Apr-2021

A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected ...

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"Waltzing" nanoparticles could advance search for better drug delivery methods

"Swirling and spinning" of therapeutic nanoparticles

15-Nov-2018

Indiana University researchers have discovered that drug-delivering nanoparticles attach to their targets differently based upon their position when they meet -- like ballroom dancers who change their moves with the music. The study is significant since the "movement" of therapeutic particles ...

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Mutation 'hotspots' in DNA could lead to new insights on cancer risks

01-Aug-2018

New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated. These mutations arise because "typos" can occur as DNA replicates during cellular division. A recent analysis, which found that random mistakes in DNA play a large ...

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Scientists watch bacteria 'harpoon' DNA to speed their evolution

15-Jun-2018

Indiana University scientists have made the first direct observation of a key step in the process that bacteria use to rapidly evolve new traits, including antibiotic resistance. Using methods invented at IU, researchers recorded the first images of bacterial appendages -- over 10,000 times ...

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Price competition for generic drugs linked to increase in manufacturing-related recalls

01-Jun-2018

Researchers from three universities have found that extreme price competition in the generic pharmaceutical market -- designed to make medications more affordable -- may be putting more patients at serious health risk, as evidenced by a higher number of product recalls caused by ...

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Preclinical study suggests path toward non-addictive painkillers

27-Oct-2017

A pre-clinical study led by Indiana University scientists reports a promising step forward in the search for pain relief methods without the addictive side effects behind the country's current opioid addiction crisis. The research finds that the use of compounds called positive allosteric ...

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New technique that could speed drug development

05-Dec-2016

Synthesizing useful new compounds is what pharmaceutical discovery and development is all about. Researchers at the School of Science at Indiana University-Purdue University Indianapolis have devised a method to substantially speed up the process. The IUPUI chemists have developed and tested a ...

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Genes linked to the effects of mood and stress on longevity identified

26-May-2016

The visible impacts of depression and stress that can be seen in a person's face -- and contribute to shorter lives -- can also be found in alterations in genetic activity, according to newly published research. In a series of studies involving both C. elegans worms and human cohorts, researchers ...

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Researchers use stem cells to identify cellular processes related to glaucoma

22-Mar-2016

Using stem cells derived from human skin cells, researchers led by Jason Meyer, assistant professor of biology, along with graduate student Sarah Ohlemacher of the School of Science at Indiana University-Purdue University Indianapolis, have successfully demonstrated the ability to turn stem cells ...

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