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Fighting blood diseases with artificial intelligence

Largest open-source database for bone marrow cell images developed

24-Nov-2021

How can we better diagnose blood diseases? A research group led by Helmholtz Munich aims to answer this question with artificial intelligence (AI). Their goal is to facilitate the time-consuming analysis of bone marrow cells under the microscope. The researchers developed the largest open-source ...

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AI helps to spot single diseased cells

01-Sep-2021

Researchers developed a novel artificial intelligence algorithm for clinical applications called “scArches”. It efficiently compares patients’ cells with a reference atlas of cells of healthy individuals. This enables physicians to pinpoint cells in disease and prioritize them for personalized ...

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Milestone in Osteoarthritis Research

New genetic risk factors and high-value drug targets discovered

27-Aug-2021

Researchers found new genetic risk factors for osteoarthritis and identified novel drug targets. Their finding is a milestone towards the development of the first ever curative treatment for osteoarthritis. The study involved an international consortium led by Helmholtz Zentrum ...

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Pancreatic organoids on newly developed chip platform

29-Jul-2021

A new organoid-on-chip platform robustly mimics the key features of human pancreas development. This is a milestone on the way to being able to diagnose pancreatic cancer at an early stage in the future. The study was conducted by an interdisciplinary team of researchers from Helmholtz Zentrum ...

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Revealing the secrets of cell competition

Which features distinguish “winner” from “loser” cells

23-Jul-2021

Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will survive or not. Defects in energy production are ...

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Plant Protector: How plants strengthen their light-harvesting membranes against environmental stress

25-Jun-2021

An international study led by Helmholtz Zentrum München has revealed the structure of a membrane-remodeling protein that builds and maintains photosynthetic membranes. These fundamental insights lay the groundwork for bioengineering efforts to strengthen plants against environmental stress, ...

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Obesity & Hypertension: Researchers Discover Novel Mechanisms

“We provide a paradigm shift in our understanding of how the hypothalamus controls blood pressure in obesity”

16-Jun-2021

Researchers have succeeded for the first time in demonstrating the role of hypothalamic astrocytes in obesity-related hypertension. In addition, they showed that the hormone leptin is involved in the increase of blood vessels in the hypothalamus of obese mice, contributing of hypertension. ...

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The Cut and Restore Protein Trick: Self-Excising Designer Proteins Report Isoform Expression

07-Jun-2021

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered reporter system developed at Helmholtz Zentrum München and the Technical University of Munich now allows ...

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Sars-Cov-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

This could partially explain the differences of COVID-19 severity reported in relation to age, gender and smoking status

19-Mar-2021

A new study uncovers which cell types can be infected by SARS-CoV-2 due to their viral entry factors. The study also suggests that increased gene expression of these viral entry factors in some individuals partially explains the differences of COVID-19 severity reported in relation to age, gender ...

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Scientists Discover a Promising New Target for Diabetes Treatment

Research group has found a promising molecular target for beta cell protection and regeneration therapy that does not carry the unintended side effects of intensive insulin therapy

29-Jan-2021

Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum München, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific ...

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