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New drug combination restores beta cell function in animal model

Potential for diabetes remission

24-Feb-2020

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for ...

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Transparent human organs allow 3D maps at the cellular level

17-Feb-2020

For the first time, researchers managed to make intact human organs transparent. Using microscopic imaging they could revealed underlying complex structures of the see-through organs at the cellular level. Resulting organ maps can serve as templates for 3D-bioprinting technologies. In the future, ...

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Unlimited potential: New ways to generate totipotent-like cells

13-Jan-2020

Totipotency is set to become a key tool for research and future medical applications. Finding efficient ways to generate totipotent-like cells is therefore crucial. In a new study, a group of researchers at Helmholtz Zentrum München found that totipotent-like cells can be induced by manipulating ...

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Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020

Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

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New algorithm detects even the smallest cancer metastases across the entire mouse body

Exposing the enemy

16-Dec-2019

Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More ...

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How do scars form?

Fascia function as a repository of mobile scar tissue

29-Nov-2019

In the riddle about the origin of scar tissue, researchers have reached an important next step. A team led by Helmholtz Zentrum München found that scars are made from a tissue beneath the skin: fascia. This new knowledge led to further discoveries about scarring mechanisms and the fascia matrix ...

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AI-driven single blood cell classification

New method to support physicians in leukemia diagnostics

14-Nov-2019

For the first time, researchers from Helmholtz Zentrum München and the University Hospital of LMU Munich show that deep learning algorithms perform similar to human experts when classifying blood samples from patients suffering from acute myeloid leukemia (AML). Their proof of concept study paves ...

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What and how much we eat might change our internal clocks and hormone responses

08-Nov-2019

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course ...

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Pluripotency or differentiation – that is the question

07-May-2019

Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells “decide” which of these two directions to take. During their research, they ...

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Protein CD30 – from witness to culprit

17-Apr-2019

Cells of certain blood cancers such as Hodgkin’s lymphoma carry the protein CD30 on their surface. The molecule is not only an indicator of a few cancers of the immune system but also increases the risk of their occurrence, according to a report in the journal Blood by researchers of the ...

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