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14 Current news of helmholtz-institut-fuer-rna-basierte-infektionsforschung-hiri

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Gut microbiota and antibiotics: Missing puzzle piece discovered

HIRI scientists identify small RNA that influences the sensitivity of the intestinal pathogen Bacteroides thetaiotaomicron to certain antibiotics

28-Mar-2024 - The intricacies of how intestinal bacteria adapt to their environment have yet to be fully explored. Researchers from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the University of California, Berkeley, USA, have now successfully closed a gap in this knowledge: ...

antibiotic resistance Bacteroides thetaiotaomicron gene expression +3
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When editing bacteria with CRISPR, less is more

Research team develops approach that increases efficiency of genome editing

13-Feb-2023 - Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the Helmholtz Institute Würzburg (HIRI) in collaboration with the Helmholtz ...

bacteria CRISPR genome editing
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Interrogating disease progression and cell processes with TIGER: in vivo and non-invasively

Peering into the cellular past: Technology records ribonucleic acids in individual living cells.

11-Jan-2023 - Do we simply ingest a diagnostic probiotic based on programmed ribonucleic acids to analyze the intestinal health from individual cells in the future? Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have ...

cells in vivo diagnostics RNA +1
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Researchers discover new type of CRISPR gene scissors

Component of bacterial immune defense paralyzes infected cells and could advance molecular biology diagnostics

05-Jan-2023 - It is an unexpected discovery by scientists at the Helmholtz Institute Würzburg in cooperation with Benson Hill, Inc. (Missouri) and Utah State University in the U.S.: They have found a nuclease, which they dubbed Cas12a2, that represents an entirely new type of CRISPR immune defense. Unlike any ...

CRISPR diagnostics nucleases
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Change with age: As bats mature their immune cells differ

Study unveils complexity of leukocytes in Egyptian fruit bat and its imprinting by age

08-Sep-2022 - A team of researchers led by Anca Dorhoi at the Friedrich-Loeffler-Institut (FLI) and Emmanuel Saliba at the Helmholtz Institute for RNA-based Infection Research (HIRI), has elucidated age-dependent variations in cellular immunity in Rousettus aegyptiacus, known as the Egyptian fruit bat, a ...

B cells flow cytometry immune cells +10
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New “decision aid” for CRISPR immune responses

Scientists show that target RNA levels influence defense against invaders

15-Jun-2022 - Friend or foe? Immune systems constantly face this question. They must recognize and clear foreign invaders without eliciting autoimmunity. Prokaryotic CRISPR-Cas systems recognize invaders based on genetic sequence. But what happens if the host genome shares the same sequences? A research team ...

CRISPR immune system RNA
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New CRISPR element regulates viral defense

Mechanism for prioritizing the immune response discovered

22-Mar-2022 - What tasks need to be done today, and which is the most urgent? People have to constantly set priorities in their daily life. Bacteria are no different: They too must prioritize when combating viruses with CRISPR. However, it was unclear how this prioritization takes place. Scientists from the ...

bacteria CRISPR CRISPR/Cas9 +3
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A boost for CRISPR research

PAM-DETECT enables faster characterisation of CRISPR immune systems

28-Feb-2022 - For many diseases, the tools of medicine are reaching their limits. CRISPR technologies open new avenues for diagnostics and therapies, although the natural source of CRISPR remains largely untapped. Scientists from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a ...

CRISPR viruses
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A sponge playing in defence

Bacteria are extremely resourceful when it comes to adapting to a given environment: A team of researchers has now discovered a new trick

09-Feb-2022 - Each year, at least 1.27 million people die from an infection with bacteria that are resistant to standard antibiotics, a study recently published in the journal The Lancet reveals. The authors fear that this number could rise to as many as ten million people by 2050. This makes the hunt for new ...

antibiotic resistance antibiotics bacteria +3
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1.5 million euros for research on SARS-CoV-2

Prestigious ERC Starting Grant awarded to HIRI

11-Jan-2022 - Principal Investigator Mathias Munschauer aims to better understand SARS-CoV-2. He now receives funding of 1.5 million euros for his research project “COVIDecode” from the European Research Council (ERC). Munschauer is the third scientist at the Helmholtz Institute for RNA-based Infection ...

coronaviruses Covid-19 ERC Starting Grant +1