Pharmaceutical research knocking on wood

Researchers establish green pharmaceutical production from wood waste

20-Nov-2023 - Sustainable and environmentally friendly production processes are playing an increasingly important role in almost all branches of industry. The production of active pharmaceutical ingredients in particular involves the use of various materials and reagents, many of which have environmentally ...

Scientists engineer new potent antibiotic

Darobactin 22 could have the potential to become the next antibiotic superstar

02-Mar-2023 - In the constant arms race with bacteria, scientists at the Centre for Structural Systems Biology CSSB together with colleagues from the Helmholtz Institute for Pharmaceutical Research Saarland HIPS have engineered a new molecule with superior antibiotic activity. The team, including DESY ...

How zebrafish larvae and AI can revolutionise drug discovery

HIPS and CISPA join forces to make future active ingredients safer

17-Feb-2023 - In the ImageTox project, the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the CISPA Helmholtz Center for Information Security are pooling their expertise in the fields of drug discovery and artificial intelligence (AI). Using state-of-the-art machine learning methods, the ...

Two bugs with one stone

Researchers optimize drug candidate against multi-resistant bacteria and parasites

20-Jun-2022 - The development of new active substances against pathogenic bacteria, parasites, fungi and viruses is gaining importance, as established antiinfectives are becoming increasingly ineffective due to the development of resistance. At the Helmholtz Institute for Pharmaceutical Research Saarland ...

Putting pathogens on mute

Researchers develop novel strategy for treating hospital germs

23-Mar-2021 - The bacterium Pseudomonas aeruginosa is among the most common causes of pneumonia and poses a major challenge to hospitals worldwide. The treatment of infections with Pseudomonas aeruginosa is usually challenging because the bacterium forms so-called biofilms, which protect it from drugs. Dr ...

How bacteria turn off an antibiotic

19-Dec-2018 - Many common antibiotics are increasingly losing their effectiveness against multi-resistant pathogens, which are becoming ever more prevalent. Bacteria use natural means to acquire mechanisms that protect them from harmful substances. For instance against the agent albicidin: Harmful ...

Hospital germs have their flaws too

Researchers discovered a target for novel medications

09-Jul-2018 - The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. One key to the success of this persistent ...