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Unmuting the genome

Epigenetic mechanisms for parent-specific genetic activation decoded

13-Jan-2022

Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), ...

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Deep learning dreams up new protein structures

Researchers show that a neural network trained exclusively to predict protein shapes can also generate new ones

03-Dec-2021

Just as convincing images of cats can be created using artificial intelligence, new proteins can now be made using similar tools. In a report in Nature, a team including researchers at the University of Washington,Rensselaer Polytechnic Institute, and Harvard University describe the development ...

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New research from Harvard explores link between walnut consumption and life expectancy

Findings show a connection between regular walnut consumption and greater longevity, as well as reduced risk of death from cardiovascular diseases

23-Aug-2021

According to a study by researchers from the Harvard T.H. Chan School of Public Health, higher walnut consumption – both in terms of the amount and frequency – may be associated with a lower risk of death and an increase in life expectancy among older adults in the U.S., compared to those who do ...

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Customized programming of human stem cells

The results open new possibilities in research

02-Dec-2020

Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues. However, the "recipes" for this conversion are often complicated and difficult to implement. Researchers at the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden, Harvard ...

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Building a better botox

Small engineering tweaks to botulinum toxin B could make it more effective and longer-lasting with fewer side effects

20-Mar-2020

Botulinum toxins -- a.k.a. botox -- have a variety of uses in medicine: to treat muscle overactivity in overactive bladder, to correct misalignment of the eyes in strabismus, for neck spasms in cervical dystonia, and more. Two botulinum toxins, types A and B, are FDA-approved and widely used. ...

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Separating Drugs with MagLev

Magneto-Archimedes levitation for identification of illicit drugs in powdered mixtures

11-Dec-2019

The composition of suspicious powders that may contain illicit drugs can be analyzed using a quick and simple method called magneto-Archimedes levitation (MagLev), according to a new study published in the journal Angewandte Chemie. A team of scientists at Harvard University, USA, has developed ...

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Combination gene therapy treats multiple age-related diseases

Treatment increases healthspan in mice and could lead to increased longevity

07-Nov-2019

As we age, our bodies tend to develop diseases like heart failure, kidney failure, diabetes, and obesity, and the presence of any one disease increases the risk of developing others. Traditional drug development targets only one condition per drug, largely ignoring the interconnectedness of ...

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Biomaterials smarten up with CRISPR

Programmable CRISPR-responsive smart materials could open the door to novel tissue engineering, bioelectronic, and diagnostic applications

26-Aug-2019

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome. It is also being harnessed ...

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€ 1 Million Research Grant Awarded for the First Time

Merck awarded a grant known as the Future Insight Prize for the first time

11-Jul-2019

Merck awarded a grant known as the Future Insight Prize for the first time. Pardis Sabeti, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, and James Crowe, Vanderbilt University Medical Center, Nashville, Tennessee, USA, were recognized for their ...

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Performance-enhancing bacteria discovered in the microbiome of elite athletes

26-Jun-2019

The human microbiome, the vast collection of microbes that colonize the surfaces lining many of our organs and our skin - is a critical pillar sustaining our general health. At any one time, 500 to 1,000 different species of bacteria inhabit us, which together contain far more genes than our ...

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