Oral drug blocks SARS-CoV-2 transmission

15-Dec-2020 - Treatment of SARS-CoV-2 infection with a new antiviral drug, MK-4482/EIDD-2801 or Molnupiravir, completely suppresses virus transmission within 24 hours, researchers in the Institute for Biomedical Sciences at Georgia State University have discovered. The group led by Dr. Richard Plemper, ...

Universal flu vaccine protects against 6 influenza viruses

09-Jan-2020 - A novel nanoparticle vaccine that combines two major influenza proteins is effective in providing broad, long-lasting protection against influenza virus in mice, showing promise as a universal flu vaccine, according to a study by the Institute for Biomedical Sciences at Georgia State ...

Ebola virus gene stolen and preserved by myotis bats

26-Jul-2018 - A gene from the deadly Ebola virus that allows the virus to escape from the human immune system has been identified in the genome of a group of bats that is found worldwide, including North America. The gene appears to have been stolen from the virus by the bats and adapted to regulate their own ...

Enzyme could protect against type of colorectal cancer by suppressing tumors

05-Jan-2017 - An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study. Researchers at Georgia State ...

Researchers discover why drug for severe COPD becomes less effective

25-Mar-2015 - Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing a tolerance to the drug after repeated use and makes the drug less ...

Ebola: New studies model a deadly epidemic

10-Feb-2015 - On Dec. 26, 2013, a two-year-old boy living in the Guinean village of Meliandou, Guéckédou Prefecture was stricken with a rare disease, caused by the filament-shaped Ebola virus. The child is believed to be the first case in what soon became a flood-tide of contagion, ravaging the West African ...

Putting the Brakes on Drug-Resistant HIV

Probing Multidrug Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors

22-Sep-2010 - HIV-1 protease inhibitors were added as a component of highly active antiretroviral therapy (HAART) in the mid-1990s, and have played a key role in that treatment regimen ever since. However, the emergence of multidrug-resistant HIV strains requires the discovery and design of conceptually new ...