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Tackling the collateral damage from antibiotics

Scientists pave the way for reducing the harmful side effects antibiotics have on gut bacteria

15-Oct-2021

Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body’s first lines of defence against pathogens and compromising the multiple beneficial effects our microbiota has for our ...

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DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins

Partners use AlphaFold, the AI system recognised last year as a solution to the protein structure prediction problem, to release more than 350,000 protein structure predictions including the entire human proteome to the scientific community

29-Jul-2021

DeepMind announced its partnership with the European Molecular Biology Laboratory (EMBL), Europe's flagship laboratory for the life sciences, to make the most complete and accurate database yet of predicted protein structure models for the human proteome. This will cover all ~20,000 proteins ...

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Induced pluripotent stem cells reveal causes of disease

Using single-cell analyses, researchers systematically searched for correlations between individual genetic variants in induced pluripotent stem cells

08-Mar-2021

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied ...

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Toadlet peptide transforms into a deadly weapon against bacteria

Potential for future medical applications

18-Jan-2021

Researchers at the Technion – Israel Institute of Technology and EMBL Hamburg have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infection. An ...

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Replication cycle of SARS-CoV-2 in 3D

Learning how SARS-CoV-2 highjacks host cell machineries will help to develop therapeutic strategies

25-Nov-2020

As the global coronavirus pandemic continues, scientists are not only trying to find vaccines and drugs to combat it, but also to continuously learn more about the virus itself. “By now we can expect the coronavirus to become seasonal,” explains Ralf Bartenschlager, professor in the Department of ...

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Scientists identify synthetic mini-antibody to combat COVID-19

By screening hundreds of synthetic mini-antibodies called sybodies, a group of scientists has identified one that might stop SARS-CoV-2 from infecting human cells

05-Nov-2020

The ability of SARS-CoV-2 to infect cells depends on interactions between the viral spike protein and the human cell surface protein ACE2. To enable the virus to hook onto the cell surface, the spike protein binds ACE2 using three finger-like protrusions, called the receptor binding domains ...

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How deadly parasites ‘glide’ into human cells


X-ray analysis reveals structure of molecular machinery of malaria and toxoplasmosis pathogens

03-Nov-2020

An investigation at DESY's X-ray source PETRA III provides new insights into the molecular machinery by which certain parasites travel through the human organism. The study, led by Christian Löw from the Hamburg branch of the European Molecular Biology Laboratory EMBL, analyzed the so-called ...

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Chromothripsis in human cancer

07-Feb-2020

Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis. This study is the largest of its kind to date, containing whole-genome sequencing (WGS) data from over 2600 tumours spanning ...

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Cancer mutations occur decades before diagnosis

07-Feb-2020

Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development. Cancer occurs as part of a lifelong ...

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Melting reveals drug targets in a living organism

Scientists identify drug targets in blood and organs

23-Jan-2020

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory and Cellzome, a GSK company, has developed a technology to ...

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