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37 Current news of Deutsches Zentrum für Neurodegenerative Erkrankungen


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Investigational gene regulation therapy lowers levels of Tau protein in the brain and could protect against Alzheimer's

Zinc finger technology as a starting point for future therapies


Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies. It leverages zinc finger proteins, which ...


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DZNE’s First Spin-off “Neuron–D” Uses Innovative Technology for Drug Testing

Drug Screening with 3D Cell Cultures


On the basis of a license agreement with the German Center for Neurodegenerative Diseases (DZNE) and the Leibniz Institute of Polymer Research Dresden (IPF), the Dresden-based start-up “Neuron-D GmbH” is developing a high-throughput system for testing drug candidates to treat neurodegenerative ...


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Coronavirus: Study finds further door opener into the cell

Researchers have identified neuropilin-1 as a factor that can facilitate SARS-CoV-2 entry into the cells’ interior


The coronavirus SARS-CoV-2 is known to infect cells via the receptor ACE2. An international research team under German-Finnish coordination has now identified neuropilin-1 as a factor that can facilitate SARS-CoV-2 entry into the cells’ interior. Neuropilin-1 is localized in the respiratory and ...


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Highly effective antibodies against the coronavirus were identified

Berlin scientists lay basis for a passive vaccination


Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered ...


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Risk gene for Alzheimer’s has early effects on the brain

Results of a study in 82 young adults


A genetic predisposition to late-onset Alzheimer’s disease affects how the brains of young adults cope with certain memory tasks. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the Ruhr-Universität Bochum report on this in the scientific journal “Current Biology”. ...


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COVID-19: Immune system on the wrong track

"Many indications suggest that the immune system stands in its own way during severe courses of COVID-19"


Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition. Experts from Charité – Universitätsmedizin Berlin, the University of Bonn, ...


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Cleaning craze in the brain

Synaptic protein waste" was collected more quickly when the presynaptic protein bassoon is missing


Synapses consist of hundreds of different proteins. For correct transmission of brain signals, their building blocks must constantly be checked for functionality and replaced by new ones. A team of researchers from the Leibniz Institute of Neurobiology Magdeburg, the German Centre for ...


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Immune cells against Alzheimer’s?

Researchers investigate new therapeutic approach


Scientists at the German Center for Neurodegenerative Diseases (DZNE), the Ludwig-Maximilians-Universität (LMU) Munich and Denali Therapeutics (South San Francisco, CA, USA)have developed an approach to stimulate immune cells of the brain in such a way that they might possibly provide better ...


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Alzheimer’s disease: Protective immune response in the brain?


LMU researchers Christian Haass and Michael Ewers have identified a factor that might possibly delay the emergence and slow the progression of Alzheimer’s disease. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the Institute for Stroke and Dementia Research (ISD) at ...


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Researchers Identify Key Proteins for the Repair of Nerve Fibers


Scientists at the German Center for Neurodegenerative Diseases (DZNE) have identified a group of proteins that help to regenerate damaged nerve cells. It is commonly accepted that neurons of the central nervous system shut down their ability to grow when they no longer need it; this occurs ...


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