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A potential new target for immunotherapies in cancer

Compounds that inhibit metabolic enzyme IL4I1 could open up new opportunities for cancer therapy


The metabolic enzyme IL4I1 (interleukin-4-induced-1) promotes the spread of tumor cells and suppresses the immune system. This was discovered by scientists from the Berlin Institute of Health (BIH) together with colleagues from the German Cancer Research Center (DKFZ) in Heidelberg. The enzyme is ...


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New technology provides insight into the development of immune cells

Barcode system enables researchers to follow which development path the cells take at the same time as identifying which genes are actively transcribed as messenger RNAs


The entire range of our blood and immune cells are derived from hematopoietic stem cells. Yet which genes influence how they develop into the different cell types? Scientists from the German Cancer Research Center (DKFZ) have now developed a new technology to answer this question. A genetic ...


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The wrong track: how papillomaviruses trick the immune system

Specific antibodies protect us against viral infections – or do they not?


Researchers at the German Cancer Research Center (DKFZ) studied the immune response to papillomaviruses in mice and discovered a hitherto unknown mechanism by which the pathogens outwit the immune system: At the beginning of the infection cycle, they produce a longer version of a protein that ...


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Molecular glue degraders – a new weapon to target “undruggable” cancer drivers


One strategy to fight cancer is to target its Achilles' heel – the addiction to growth-promoting proteins. However, as many of these so-called cancer drivers are notoriously difficult to block with a drug, this requires novel and unconventional approaches. In cooperation with the German Cancer ...


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CAR T cell therapy: potential for considerable savings

An alternative method could reduce the production costs to a tenth of the current commercial price


Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the production of ...


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"Explosion in cancer genome" much more common than expected

Chromothripsis often generates fusions of chromosomal fragments that promote tumor development


Chromothripsis is a form of genome instability by which one or a few chromosomes virtually "explode(s)" in a presumably single catastrophic event. According to current opinion, chromothripsis occurs at the beginning of tumor development and plays an important role in cancer onset. While the ...


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Using mini colons to detect functional differences and weaknesses of colorectal cancer

Pooled in vitro and in vivo CRISPR-Cas9 screening identifies tumor suppressors in human colon organoids


One of the main features of colorectal cancer is that there are considerable differences between the tumors of individual patients - at genetic level and hence in terms of the response to treatment too. Researchers from the German Cancer Consortium (DKTK) have developed a method that allows these ...


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Preventing metastasis - an antibody with therapeutic potential

New principle for slowing down the metastatic dissemination of cancer cells


A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists at the German Cancer Research Center in Heidelberg (DKFZ) and the Mannheim Medical Faculty of the University of Heidelberg have ...


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Remote medical image diagnosis

Startup provides app free of charge during corona crisis


The current crises caused by the fast spread of covid-19 is forcing clinics and its medical staff to take actions that otherwise would require months or years: Home office and the provision of mobile software solutions. mbits, a spin-off of the German Cancer Research Center (DKFZ), has ...


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Unstable chromosomes can promote breast cancer

Altered chromosomes lead to treatment resistance


If chromosomes are unevenly distributed or otherwise altered during cell division, this normally damages the daughter cells and impairs their viability. Not in cancer cells, however, in which chromosome instability can actually confer a growth advantage under certain circumstances. Moreover, as ...


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