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41 Current news of Deutsches Krebsforschungszentrum

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How dying cells prevent dangerous immune reactions

14-Jan-2020

Dying cells in the body can keep the immune system in check, thus preventing unwanted immune responses against the body's own tissues. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now identified a receptor on immune cells that activates this ...

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Innovative method delivers new insights into the stem cell microenvironment – Bone marrow in 3D

02-Jan-2020

Researchers from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have developed new methods to reveal the three-dimensional organisation of bone marrow at a single cell level. Since bone marrow harbours blood stem cells ...

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Cell death or cancer growth: a question of cohesion

21-Nov-2019

Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death – or does the opposite, namely stimulates cancer cell growth. Scientists from the German Cancer Research Center (DKFZ) have now shown that the impact of CD95 activation depends on whether there are isolated ...

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Intestinal bacteria could influence the development of multiple sclerosis

14-Nov-2019

A tryptophan-free diet in mice changes the composition of the intestinal bacteria and protects against symptoms of experimentally generated multiple sclerosis. Tryptophan is an essential amino acid, i.e. a protein component which cannot be produced by the body itself, but must be obtained from ...

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Protein misfolding as a risk marker for Alzheimer’s disease – up to 14 years before the diagnosis

17-Oct-2019

In symptom-free individuals, the detection of misfolded amyloid-β protein in the blood indicated a considerably higher risk of Alzheimer's disease – up to 14 years before a clinical diagnosis was made. Amyloid-β folding proved to be superior to other risk markers evaluated, as shown by scientists ...

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Black sheep: Why some strains of the Epstein Barr virus cause cancer

11-Sep-2019

The Epstein Barr virus (EBV) is very widespread. More than 90 percent of the world's population is infected – with very different consequences. Although the infection does not usually affect people, in some it can cause glandular fever or various types of cancer. Researchers at the German Cancer ...

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Making cancer stem cells visible to the immune system

New results may enable innovative treatment concept against leukemia

19-Jul-2019

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal "Nature", scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can ...

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Cancer drugs promote stem cell properties of colorectal cancer

20-May-2019

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This ...

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Fighting colon cancer with killer cells

03-May-2019

Genetically modified immune cells can successfully destroy colon cancer cells. This has been demonstrated for the first time by scientists from the German Cancer Consortium (DKTK) at Georg Speyer House in Frankfurt using mini-tumors produced in the lab. They are making use of a new approach in ...

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Targeted approach to therapy for rare type of bone cancer

12-Apr-2019

Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT) Heidelberg, the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of ...

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