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31 Current news of Cold Spring Harbor Laboratory Press


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Novel gene variants identified in male breast cancer


Male breast cancer (MBC) is a very rare tumor type, occurring in just 1% of all breast cancer cases, and the underlying genetic causes and treatment of MBC is not well understood. In a paper researchers from Italy and the U.S. describe novel genetic variants found in a hormone receptor positive ...


Novel regulator inhibits toxic protein aggregates in Huntington's disease


Huntington's disease is a neurodegenerative disorder characterized by huntingtin protein aggregates in a patient's brain, but how these aggregates form is not well understood. In a study published in Genome Research, researchers developed a novel computational strategy to identify interaction ...


Mutation detection in human in vitro fertilized embryos using whole-genome sequencing


Pre-implantation genetic diagnosis (PGD) is used in fertility clinics to detect large chromosomal abnormalities or genetic mutations passed on by parents to their in vitro fertilized (IVF) embryos. However, it is not possible to comprehensively scan the embryo's genome to detect spontaneous ...


New insights from the Mouse ENCODE Project published in Genome Research


Genome Research publishes three articles in conjunction with articles published in other journals describing recent advances from the Mouse ENCODE Project Consortium. Initially launched to complement the human Encyclopedia of DNA Elements (ENCODE) Project in 2008, the Mouse ENCODE Project aims to ...


Seamless gene correction of β-thalassemia mutations in patient cells


A major hurdle in gene therapy is the efficient integration of a corrected gene into a patient's genome without mutating off-targetsites. In a paper published inGenome Research, scientists have used CRISPR/Cas genome editing technology to seamlessly and efficiently correct disease-causing ...


In the bacterial world of your mouth, nurture wins out over nature


The human mouth is home to a teeming community of microbes, yet still relatively little is known about what determines the specific types of microorganisms that live there. Is it your genes that decide who lives in the microbial village, or is it your environment? In a study published in Genome ...


Differences between human twins at birth highlight importance of intrauterine environment


Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published in Genome Research, researchers have for the first time shown that the environment experienced in the womb defines ...


Gut microbes battle a common set of viruses shared by global populations


The human gut is home to a teeming ecosystem of microbes that is intimately involved in both human health and disease. But while the gut microbiota is interacting with our body, they are also under constant attack from viruses. In a study published in Genome Research, researchers have analyzed ...


RNA regulator of melanoma could be a new target for cancer therapy


Melanoma is the most deadly form of skin cancer, estimated by the National Cancer Institute to afflict more than 70,000 people in the United States annually and the incidence rate continues to rise. In a study published in Genome Research, researchers have identified a previously unknown ...


Genetic study unravels ancient links between African and European populations


Large numbers of people moved between Africa and Europe during recent and well-documented time periods such as the Roman Empire, the Arab conquest, and the slave trade, and genetic evidence of these migrations lives on in Europeans today. But were there more ancient migrations? In a study ...


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