How cells handle a sticky, toxic, but absolutely essential molecule

A new study shows that a protein known for its role in metabolism also helps deliver heme where it's needed

18-Sep-2018 - Do you enjoy breathing air? You should spare a thought once in a while for heme, an iron-containing molecule essential to all organisms engaged in an air-breathing lifestyle. Heme molecules are most famously part of hemoglobin, the oxygen-transporting protein in blood, but they are also ...

Mechanism in Alzheimer's-related memory loss

Study uncovers role of Neuroligin-1 protein

21-Jan-2014 - Cleveland Clinic researchers have identified a protein in the brain that plays a critical role in the memory loss seen in Alzheimer's patients, according to a study to be published in the journal Nature Neuroscience and posted online. The protein – Neuroligin-1 (NLGN1) – is known to be involved ...

APEIRON acquires option to license rights to oncology compounds from Cleveland Clinic

17-Mar-2011 - APEIRON Biologics AG announced that it has entered into an exclusive option to license from the Cleveland Clinic a number of novel compounds. These compounds are currently in development at Cleveland Clinic as drug candidates for treatment of various cancers, designed to fight cancer based on ...

Red wine compound increases anti-tumor effect of rapamycin

Rapamycin-resveratrol treatment promotes activity against breast cancer

15-Feb-2011 - Researchers from Cleveland Clinic's Lerner Research Institute have discovered that resveratrol – a compound found in red wine – when combined with rapamycin can have a tumor-suppressing effect on breast cancer cells that are resistant to rapamycin alone. The research – recently published in ...