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Low levels of a simple sugar – a new biomarker for severe MS?

Discovery could pave the way for a new therapeutic approach

17-May-2021

Researchers from the ECRC in Berlin, together with scientists from the United States and Canada, have discovered a sugar molecule whose levels are reduced in the blood of patients with particularly severe multiple sclerosis. Their discovery could pave the way for a new therapeutic approach, the ...

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AI-based analysis system for the diagnosis of breast cancer

For the first time, morphological, molecular and histological data are integrated in a single analysis

12-Mar-2021

Researchers at TU Berlin and Charité – Universitätsmedizin Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). Two further developments make this system unique: For the first time, ...

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How the immune system paves the way for SARS-CoV-2

SARS-CoV-2 uses an immune system defense mechanism as a port of entry

22-Feb-2021

The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. Most people infected with SARS-CoV-2 are able to recover from the disease at home ...

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The human helpers of SARS-CoV-2

Drug targets were identified

23-Dec-2020

Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from the Berlin Institute of Health (BIH), Charité – Universitätsmedizin ...

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How SARS-CoV-2 reaches the brain

For the first time electron microscope images of intact coronavirus particles inside the olfactory mucosa produced

01-Dec-2020

Using post-mortem tissue samples, a team of researchers from Charité – Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does. The results, which show that ...

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Highly effective antibodies against the coronavirus were identified

Berlin scientists lay basis for a passive vaccination

25-Sep-2020

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered ...

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COVID-19: Immune system on the wrong track

"Many indications suggest that the immune system stands in its own way during severe courses of COVID-19"

07-Aug-2020

Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition. Experts from Charité – Universitätsmedizin Berlin, the University of Bonn, ...

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HIV-1: The undercover agent

The AIDS virus HIV-1 goes largely unnoticed by T-cells of the immune system thanks to an ingenious propagation strategy

30-Jul-2020

Antibodies are not the only protection against viruses: At a much earlier stage, infected cells detect components of a virus with the help of internal sensors and trigger an immune response. This is an element of what is known as innate immunity, and helps prevent viruses from spreading further. ...

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Could the blood of COVID-19 patients be used to predict disease progression?

Study discovers differences in the blood samples of severe and mild cases

09-Jun-2020

Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have identified 27 proteins which are present at different levels in the blood of COVID-19 patients, depending on the severity of their symptoms. These biomarker profiles could be used to predict disease ...

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Cleaning craze in the brain

Synaptic protein waste" was collected more quickly when the presynaptic protein bassoon is missing

28-May-2020

Synapses consist of hundreds of different proteins. For correct transmission of brain signals, their building blocks must constantly be checked for functionality and replaced by new ones. A team of researchers from the Leibniz Institute of Neurobiology Magdeburg, the German Centre for ...

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