Artificial intelligence identifies anti-aging drug candidates targeting ‘zombie’ cells

New platform has potential to fuel advances in senolytic anti-aging compounds and longevity research

09-May-2023 - Anew publicationin the May issue ofNature Agingby researchers from Integrated Biosciences, a biotechnology start-up company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class ...

How the coronavirus interacts with cells

First global atlas of direct interactions between SARS-CoV-2 RNA and human host cells

06-Jan-2021 - Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One ...

Merck and Broad Institute Announce CRISPR License Framework to Encourage Innovation

19-Jul-2019 - Merck and the Broad Institute of MIT and Harvard (Boston, Massachusetts) announced an agreement to offer non-exclusive licenses to CRISPR intellectual property (IP) under their respective control for use in commercial research and product development. “Together with the Broad Institute, we are ...

€ 1 Million Research Grant Awarded for the First Time

Merck awarded a grant known as the Future Insight Prize for the first time

11-Jul-2019 - Merck awarded a grant known as the Future Insight Prize for the first time. Pardis Sabeti, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, and James Crowe, Vanderbilt University Medical Center, Nashville, Tennessee, USA, were recognized for their ...

How a child made scientists think of cytokines as knobs instead of switches

Development could help those suffering forms of cancer, kidney disease, blood disorders

13-Mar-2017 - A n unusual case of a rare anemia is opening scientists up to a new way of thinking about how to adapt and employ cytokines, messenger molecules of the blood and immune system, as tools for treatment — tools that are more analog than digital — and to illustrate the promise of precision ...

Bayer Expands Collaboration with Broad Institute of MIT and Harvard

01-Apr-2015 - Bayer HealthCare (Bayer) has expanded its collaboration with the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University to include cardiovascular genomics and drug discovery. The goal of this new part of the alliance is to leverage insights from human genetics to ...

Genomic sequencing reveals mutations, insights into 2014 Ebola outbreak

Broad researchers and colleagues find clues about origin, transmission of deadly virus

01-Sep-2014 - In response to an ongoing, unprecedented outbreak of Ebola virus disease (EVD) in West Africa, a team of researchers from the Broad Institute and Harvard University, in collaboration with the Sierra Leone Ministry of Health and Sanitation and researchers across institutions and continents, has ...

Epigenetic control of cardiogenesis

Non-coding RNA is essential for normal embryonic cardiogenesis

01-Feb-2013 - Many different tissues and organs form from pluripotent stem cells during embryonic development. To date it had been known that these processes are controlled by transcription factors for specific tissues. Scientists from the Max Planck Institute for Molecular Genetics in Berlin, in collaboration ...

New Research Center to Focus on Mammalian Single Cell Genomics

01-Jun-2012 - The Broad Institute and Fluidigm Corporation have announced the launch of a new research center dedicated to accelerating the development of research methods and discoveries in mammalian single-cell genomics. The Single-Cell Genomics Center is also expected to act as a hub for collaboration among ...

Researchers shine light on how some melanoma tumors evade drug treatment

29-Nov-2010 - Researchers shine light on how some melanoma tumors evade drug treatment Findings pinpoint a critical gene involved in melanoma growth, provide a framework for discovering ways to tackle cancer drug resistance The past year has brought to light both the promise and the frustration of developing ...