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The human helpers of SARS-CoV-2

Drug targets were identified


Like all viruses, the novel coronavirus is dependent on help from the human host cell. Proteins are the functional units of the cell and enable the virus to enter the host cell or help the virus to replicate. Scientists from the Berlin Institute of Health (BIH), Charité – Universitätsmedizin ...


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When does it make sense to develop a new therapeutic agent?

Criteria that research must meet so that a substance that shows promise in the laboratory can actually be developed into a clinically effective drug


Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, along with colleagues from the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME-TMP) in Frankfurt am Main and PAASP GmbH in Heidelberg, have compiled a catalogue of recommendations ...


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New software detects disease-causing gene mutations

Software finds "needle in a haystack" e.g. in the diagnosis of rare diseases


A serious illness is often the result of a single genetic defect. But given that two healthy people already have around three million differences in their genetic make-up, it is no easy task to pick out the one disease-causing deviation from the many harmless gene variants. Scientists at the ...


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A potential new target for immunotherapies in cancer

Compounds that inhibit metabolic enzyme IL4I1 could open up new opportunities for cancer therapy


The metabolic enzyme IL4I1 (interleukin-4-induced-1) promotes the spread of tumor cells and suppresses the immune system. This was discovered by scientists from the Berlin Institute of Health (BIH) together with colleagues from the German Cancer Research Center (DKFZ) in Heidelberg. The enzyme is ...


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HIV-1: The undercover agent

The AIDS virus HIV-1 goes largely unnoticed by T-cells of the immune system thanks to an ingenious propagation strategy


Antibodies are not the only protection against viruses: At a much earlier stage, infected cells detect components of a virus with the help of internal sensors and trigger an immune response. This is an element of what is known as innate immunity, and helps prevent viruses from spreading further. ...


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The dangerous dual role of the immune system in COVID-19

Immune cells occasionally overshoot the mark and, due to their excessive reaction, sometimes cause greater damage than the virus itself


Infection with the novel coronavirus SARS-CoV-2 follows a highly variable course: some of those infected do not even notice it, while others become so seriously ill that their lives are placed at risk. Scientists from the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin ...


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Precise diagnostics with artificial intelligence

BIH Digital Health Accelerator guides Aignostics GmbH through its spin-off


The usual way to determine if a suspicious lump is cancerous involves microscopic examination in a pathology laboratory. To ease the workload of pathologists who face a rising number of cancer cases and increasingly finer molecular details and to enable tailored treatments, scientists at the ...


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What cells does the novel coronavirus attack?


Scientists from the Berlin Institute of Health (BIH), Charité – Universitätsmedizin Berlin and the Thorax Clinic at Heidelberg University Hospital, whose collaboration is taking place under the auspices of the German Center for Lung Research (DZL), have examined samples from non-virus infected ...


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Fine-tuning gene scissors

Computer model for adjusting CRISPR-Cas9 enables more precise cuts in the genome


The CRISPR-Cas9 gene-editing tool makes it possible to modify the genetic material of organisms. But CRISPR technology is not perfect. Frequently, these molecular “scissors” also make incisions in genetic regions that have a similar appearance to the target sequence. Researchers at the Berlin ...


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DNA saturation mutagenesis: Identifying which mutations really cause disease


Scientists at the Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, working with colleagues from the United States, have selectively modified the control regions of 20 disease-relevant genes. This enabled them to identify precisely those modifications that have the ...


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