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Synthesis of medicinally privileged heterocycles through dielectric heating

10-Mar-2017

Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one ...

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Targeting the PI3K/AKT/mTOR pathway in prostate cancer development and progression

14-Jun-2016

Dr Claudio Festuccia (University of L'Aquila, Italy) discusses experimental and clinical data on the pharmacological inhibition of the Akt/mTOR pathways. These pathways play a key role in the modulation of cellular proliferation, tumor growth and survival through phosphorylation of different ...

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Investigating plasma levels as a biomarker for Alzheimer's disease

20-Apr-2016

A Centre for Healthy Brain Ageing (CHeBA) paper presents the first detailed study of the relationship between plasma levels of two amyloid beta peptides (Aβ1-40 and Aβ1-42), brain volumetrics (measures studying the size of brain, which shrinks with Alzheimer's disease) and cognitive performance ...

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Drug-loaded nanocarriers in tumor targeted drug delivery

09-Mar-2016

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a leading cause of death and the burden is expected to grow worldwide due to the growth and aging of the population, mainly in less developed countries, in which about 82% of the world's ...

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Two-way clustering method for QSAR modeling of diverse set of chemicals

02-Mar-2016

Toxicologists use a large number of tests to assess potential toxicity of chemicals to human and ecological health, a thorough analysis of one chemical requiring $2 to 4 million and a few years of time. One important toxicological property of chemicals is mutagenicity. Both drugs and ...

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Tyrosinase inhibitors from terrestrial and marine resources

22-Feb-2016

Tyrosinase is a multifunctional copper-containing enzyme widely distributed in microorganisms as well as plants and animals which has a primordial role in melanin biosynthesis thus impacting on skin color and pigmentation. This particular enzyme has the ability to catalyze the hydroxylation of ...

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From tamoxifen to dendrogenin A: Discovery of a mammalian tumor suppressor metabolite

19-Jan-2016

Researchers from the Cancer Research Center of Toulouse have conducted the first comprehensive review on dendrogenin A (DDA). DDA is a steroidal alkaloid arising from cholesterol and histamine cross-metabolization that they recently discovered. Importantly, they found that DDA is a tumor ...

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