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Defined Blockade: Enzymatic photocaging for the study of gene regulation through DNA methylation

26-Nov-2020

The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a German team has developed a new method by which specific methylation sites can be blocked and then unblocked at a precise time through irradiation with ...

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Root Bacterium to Fight Alzheimer's

Rhizolutin dissociates β and tau aggregates

04-Nov-2020

A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer’s. Rhizolutin, a novel class of compounds with a tricyclic framework, significantly dissociates the protein aggregates associated with Alzheimer’s disease both in vivo and ...

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Combination Therapy against Cancer

Synergistic anticancer therapy with two cell killer agent systems in one nanocapsule

15-Oct-2020

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach. All agents are encapsulated in nanocapsules with a protein shell to be delivered to the ...

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Well shielded but highly active

Architecture is key: Biomolecule metal–organic hybrids with high bioactivity

03-Jul-2020

Biomacromolecules incorporated into tailored metal–organic frameworks using peptide modulators are well shielded but highly active thanks to carefully tuned nanoarchitecture. As scientists report in the journal Angewandte Chemie, this strategy can be used to synthesize an “artificial cell” that ...

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Better Than Cyclodextrins

Molecular Containers for the Sequestration of Neurotransmitter Drugs in Water

19-Jun-2020

Molecular containers that remove drugs, toxins, or malodorous substances from the environment are called sequestering agents. Scientists have developed a class of molecular containers that specifically sequester neurotransmitter antagonists. The barrel-shaped molecules called Pillar[n]MaxQ bind ...

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A molecular shield for near-infrared fluorescent dyes

Stable and Functional Dyes for Near-Infrared Fluorescence Imaging of Living Subjects

05-Jun-2020

Scientists can monitor biomolecular processes in live tissue by noninvasive optical methods, such as fluorescence imaging. However, the fluorescent dyes used for that purpose are often rather unstable, and photobleaching, lack of specificity, and poor pharmacokinetics are recurrent issues. US ...

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Staining Cycles with Black Holes

Ultrafast repeated staining and destaining of cell samples for tumor diagnostics

27-Mar-2020

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the journal Angewandte Chemie, scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly ...

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Amplification and imaging of microRNA as a biomarker to detect tumor development

Cancer Diagnostics

18-Mar-2020

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells. A team of scientists from China has found a way to amplify miRNA in live tumor cells for bioimaging. As they report in ...

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One Drug, Three Action Modes

Chemotherapy and photodynamic therapy combined in a single drug to fight resistant cancers

17-Mar-2020

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action. Such a single-drug ...

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Making Puffer Fish Toxin in a Flask

Total synthesis of tetrodotoxin

10-Mar-2020

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin. In low doses, tetrodotoxin is shown in clinical trials to be a replacement for opioids for relieving cancer related pain. In the ...

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