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A Hairpin to Fight Cancer

Bicyclic protein mimetics inhibit the oncogene β-catenin

17-May-2021

The inhibition of pathological protein–protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that binds to β-catenin—a protein associated with certain types of tumor. The ...

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Protected by Nanobrushes

Inserting active-agent proteins into cancer cells using antibodies

11-May-2021

The ability of antibodies to recognize specific cancer cells is used in oncology to specifically target those cells with small active agents. Research published in the journal Angewandte Chemie shows that scientists have now built a transport system that delivers even large protein-based drugs ...

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Radical Attack on Live Cells

Stimulation of tiny areas on cellular surfaces with free radicals using a microfluidic probe

08-Apr-2021

Is there a way to chemically manipulate small, confined areas on cellular surfaces? Scientists have developed a microfluidic probe to send a flow of free radicals on live cells and track the outcome using fluorescence imaging. As outlined in the journal Angewandte Chemie, this approach makes it ...

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Fighting Cancer from a Chair

Platinum complex inhibits metastasis through conformational modulation of heparan sulfate

27-Jan-2021

Cisplatin has been used to treat cancer since the 1970s. Since then, many other platinum-containing cytostatic drugs have been developed, such as triplatinNC, a highly charged complex that contains three ligand-bridged platinum atoms. Unlike cisplatin, this drug also directly inhibits metastasis. ...

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Inhibitor in a Tunnel

New method for the development of choline acetyltransferase inhibitors

04-Jan-2021

The enzyme choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine and could be a target molecule for pharmaceuticals. A Swedish research team has now determined the mechanism by which arylvinylpyridinium (AVP), a known class of ChAT inhibitors, functions. ...

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Useful “Fake” Peptides

Oligourea foldamers mimic peptides’ alpha-helices and effectively bind to drug targets

09-Dec-2020

Some useful drugs consist of peptides acting on their protein targets. To make them more efficient and stable, scientists have found a way to replace crucial segments of the peptides with ureido units. These oligoureas, which are composed of urea-based units, fold into a structure similar to that ...

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Defined Blockade: Enzymatic photocaging for the study of gene regulation through DNA methylation

26-Nov-2020

The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a German team has developed a new method by which specific methylation sites can be blocked and then unblocked at a precise time through irradiation with ...

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Root Bacterium to Fight Alzheimer's

Rhizolutin dissociates β and tau aggregates

04-Nov-2020

A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer’s. Rhizolutin, a novel class of compounds with a tricyclic framework, significantly dissociates the protein aggregates associated with Alzheimer’s disease both in vivo and ...

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Combination Therapy against Cancer

Synergistic anticancer therapy with two cell killer agent systems in one nanocapsule

15-Oct-2020

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach. All agents are encapsulated in nanocapsules with a protein shell to be delivered to the ...

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Well shielded but highly active

Architecture is key: Biomolecule metal–organic hybrids with high bioactivity

03-Jul-2020

Biomacromolecules incorporated into tailored metal–organic frameworks using peptide modulators are well shielded but highly active thanks to carefully tuned nanoarchitecture. As scientists report in the journal Angewandte Chemie, this strategy can be used to synthesize an “artificial cell” that ...

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