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Affinity discovers potent SARS-CoV-2 antibodies

Affinity Biosciences antibody binding to the SARS-CoV-2 virus spike protein

07-Jul-2020

Melbourne-based Affinity Biosciences Pty Ltd (Affinity), a privately held company focused on antibody discovery for cancer therapeutics, announced the discovery of potent antibodies with therapeutic potential against COVID-19.. In March, Affinity commenced screening its proprietary library of one ...

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Pfizer and BioNTech Announce Early Positive Data from an Ongoing Phase 1/2 Study of mRNA-based Vaccine Candidate Against SARS-CoV-2

Efforts to manufacture the leading candidates, at risk, are gearing up

02-Jul-2020

Pfizer Inc. and BioNTech SE announced preliminary U.S. data from the most advanced of four investigational vaccine candidates from their BNT162 mRNA-based vaccine program, Project Lightspeed, against SARS-CoV-2, the virus causing the current global pandemic. The BNT162 program is evaluating at ...

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A novel strategy to generate useful chiral compounds

Newly designed ligands for a catalytic reaction to synthesize drugs and useful compounds

01-Jul-2020

Currently, various therapeutic compounds in the market, such as proteins, enzymes, and amino acids, are "chiral compounds"--molecules with two structures that are "mirror" images of each other but cannot be superimposed. Although the two variants of the molecule, also called "enantiomers," are ...

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BioNTech to Raise USD 250 Million in Private Placement

The private placement includes an investment in ordinary shares and a investment in 4-year mandatory convertible notes

30-Jun-2020

BioNTech SE announced a private investment of USD 250 million (EUR 223 million) by Temasek and other accredited investors. The private placement includes an investment of approximately USD 139 million in ordinary shares and a USD 112 million investment in 4-year mandatory convertible notes. “We ...

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X-rays size up protein structure at the 'heart' of COVID-19 virus

The protease protein is both shaped like a heart and functions as one, allowing the virus to replicate and spread

30-Jun-2020

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. The X-ray measurements mark an important first step in the ...

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Chemists find way to create "the building blocks of life"

Turning alcohol into key ingredients for new medicines

30-Jun-2020

Chemists have found a way to turn alcohol into amino acids, the building blocks of life. In a study published in the journal Nature Chemistry, researchers explained the transformation, which involves selectively identifying and replacing molecular bonds with unprecedented precision. The finding ...

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Merck initiates clinical Covid-19 study

First clinical trial of TLR7 and 8 inhibitor as a potential treatment for severe symptoms of Covid-19 infection

26-Jun-2020

Merck announced the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application (IND) for M5049 for the treatment of patients with Covid-19 pneumonia. Merck will initiate a Phase II randomized, controlled clinical study evaluating the safety and efficacy of M5049 ...

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CSIC researchers will use a type of 'coronavirus parasite' to combat it

A project studies specific forms of coronavirus parasites to interfere with the replication capacity of SARS-CoV-2 and promote its elimination

23-Jun-2020

A team of researchers from the Spanish National Research Council (CSIC) is leading a project to develop antiviral drugs to prevent the replication of the SARS-CoV-2 coronavirus, which caused the Covid-19 pandemic. The study focuses on the so-called DIPs (Defective Interfering Particles), a common ...

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Better Than Cyclodextrins

Molecular Containers for the Sequestration of Neurotransmitter Drugs in Water

19-Jun-2020

Molecular containers that remove drugs, toxins, or malodorous substances from the environment are called sequestering agents. Scientists have developed a class of molecular containers that specifically sequester neurotransmitter antagonists. The barrel-shaped molecules called Pillar[n]MaxQ bind ...

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CureVac Receives Regulatory Approval to Initiate Phase 1 Clinical Trial of its SARS-CoV-2 Vaccine Candidate

Trial will start promptly and will be conducted in Germany and Belgium

18-Jun-2020

CureVac AG announced that the German Health Authority Paul-Ehrlich-Institute (PEI) and the Belgian Federal Agency for Medicines and Health Products (FAMHP) have approved the Phase 1 clinical trial for its vaccine program to prevent SARS-CoV-2 infection. The trial will be conducted in Germany and ...

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