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Study finds fatty acid that kills cancer cells

This discovery has many implications, including a step toward a potential treatment for cancer

13-Jul-2020

Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published in Developmental Cell on July 10, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells. Ferroptosis is an ...

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Bats offer clues to treating COVID-19

To combat COVID-19, we need to regulate our immune systems to resemble those of bats

13-Jul-2020

Bats are often considered patient zero for many deadly viruses affecting humans, including Ebola, rabies, and, most recently, the SARS-CoV-2 strain of virus that causes coronavirus. Although humans experience adverse symptoms when afflicted with these pathogens, bats are remarkably able to ...

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BU researchers design artificial genes to sense cellular responses to drugs

Understanding cell communication believed to be the key to developing new and improved medications for a wide range of health conditions.

08-Jul-2020

Researchers from Boston University School of Medicine (BUSM) have developed and implemented a new way to better understand how human cells communicate with each other, how this communication is disrupted in human diseases and how this can be corrected pharmacologically. Their method consists of a ...

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Compounds halt SARS-CoV-2 replication by targeting key viral enzyme

Four promising antiviral drug candidates identified and analyzed by a University of Arizona-University of South Florida team in the preclinical study

08-Jul-2020

As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus. University of South Florida Health (USF Health) Morsani College of Medicine scientists recently worked with ...

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Researchers identify multiple molecules that shut down SARS-Cov-2 polymerase reaction

A library of molecules with unique structural and chemical features inhibit the novel coronavirus polymerase, a key drug target for COVID-19

02-Jul-2020

SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. Terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune ...

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New approach drives bacteria to produce potential antibiotic, antiparasitic compounds

Researchers used a variety of techniques, including genome mining, to identify bacteria that produce defensive compounds in response to hormone exposure

30-Jun-2020

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. The researchers wanted to ...

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X-rays size up protein structure at the 'heart' of COVID-19 virus

The protease protein is both shaped like a heart and functions as one, allowing the virus to replicate and spread

30-Jun-2020

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. The X-ray measurements mark an important first step in the ...

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Chemists find way to create "the building blocks of life"

Turning alcohol into key ingredients for new medicines

30-Jun-2020

Chemists have found a way to turn alcohol into amino acids, the building blocks of life. In a study published in the journal Nature Chemistry, researchers explained the transformation, which involves selectively identifying and replacing molecular bonds with unprecedented precision. The finding ...

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Scientists produce first open source all-atom models of full-length COVID-19 'S' protein

The protein structure facilitates viral entry into host cells making it a key target for vaccine and antiviral drug development

23-Jun-2020

The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The "spike" or S protein facilitates viral entry into host cells. Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh University in ...

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Cellular nanosponges could soak up SARS-CoV-2

A nanoparticle decoy with the virus' natural targets lure SARS-CoV-2 away from cells

22-Jun-2020

Scientists are working overtime to find an effective treatment for COVID-19, the illness caused by the new coronavirus, SARS-CoV-2. Many of these efforts target a specific part of the virus, such as the spike protein. Now, researchers reporting in Nano Letters have taken a different approach, ...

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