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5,336 Current news from usarss
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This discovery has many implications, including a step toward a potential treatment for cancer
Researchers have demonstrated that a fatty acid called dihomogamma-linolenic acid, or DGLA, can kill human cancer cells. The study, published in Developmental Cell on July 10, found that DGLA can induce ferroptosis in an animal model and in actual human cancer cells. Ferroptosis is an ...
To combat COVID-19, we need to regulate our immune systems to resemble those of bats
Bats are often considered patient zero for many deadly viruses affecting humans, including Ebola, rabies, and, most recently, the SARS-CoV-2 strain of virus that causes coronavirus. Although humans experience adverse symptoms when afflicted with these pathogens, bats are remarkably able to ...
Understanding cell communication believed to be the key to developing new and improved medications for a wide range of health conditions.
Researchers from Boston University School of Medicine (BUSM) have developed and implemented a new way to better understand how human cells communicate with each other, how this communication is disrupted in human diseases and how this can be corrected pharmacologically. Their method consists of a ...
Four promising antiviral drug candidates identified and analyzed by a University of Arizona-University of South Florida team in the preclinical study
As the death toll from the COVID-19 pandemic mounts, scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious respiratory virus. University of South Florida Health (USF Health) Morsani College of Medicine scientists recently worked with ...
A library of molecules with unique structural and chemical features inhibit the novel coronavirus polymerase, a key drug target for COVID-19
SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. Terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host's immune ...
Researchers used a variety of techniques, including genome mining, to identify bacteria that produce defensive compounds in response to hormone exposure
Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. The researchers wanted to ...
The protease protein is both shaped like a heart and functions as one, allowing the virus to replicate and spread
A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. The X-ray measurements mark an important first step in the ...
Turning alcohol into key ingredients for new medicines
Chemists have found a way to turn alcohol into amino acids, the building blocks of life. In a study published in the journal Nature Chemistry, researchers explained the transformation, which involves selectively identifying and replacing molecular bonds with unprecedented precision. The finding ...
The protein structure facilitates viral entry into host cells making it a key target for vaccine and antiviral drug development
The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The "spike" or S protein facilitates viral entry into host cells. Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh University in ...
A nanoparticle decoy with the virus' natural targets lure SARS-CoV-2 away from cells
Scientists are working overtime to find an effective treatment for COVID-19, the illness caused by the new coronavirus, SARS-CoV-2. Many of these efforts target a specific part of the virus, such as the spike protein. Now, researchers reporting in Nano Letters have taken a different approach, ...