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Tracking cancer's immortality factor

How a key cancer mutation activates telomerase, the ‘anti-aging enzyme’ that makes tumour cells immortal

05-Jun-2020

Canadian scientists have achieved a first in the study of telomerase, an essential enzyme implicated in aging and cancer. In the journal Molecular Cell, scientists from Université de Montréal used advanced microscopy techniques to see single molecules of telomerase in living cells. A flaw in the ...

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New more powerful genome editing method

Scientists can now edit multiple genome fragments at a time

20-Mar-2020

Toronto scientists can now edit multiple sites in the genome at the same time to learn how different DNA stretches co-operate in health and disease. CRISPR-based DNA editing has revolutionized the study of the human genome by allowing precise deletion of any human gene to glean insights into its ...

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Shaping the rings of molecules

Boon for the making of pharmaceuticals and electronics

25-Feb-2020

Macrocycles are molecules made of large rings of atoms. Despite being relatively big and flexible, the molecules don't always stay "floppy" -- they can actually lock themselves into specific shapes and geometries. In manufacturing, controlling the three-dimensional shapes of macrocycles is ...

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A self-cleaning surface that repels even the deadliest superbugs

17-Dec-2019

A team of researchers at McMaster University has developed a self-cleaning surface that can repel all forms of bacteria, preventing the transfer of antibiotic-resistant superbugs and other dangerous bacteria in settings ranging from hospitals to kitchens. The new plastic surface - a treated form ...

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How a protein in your brain could protect against Alzheimer's disease

New research sets the stage for new therapeutic strategies for Alzheimer's disease

17-Dec-2019

Research shows that white blood cells in the human brain are regulated by a protein called CD33--a finding with important implications in the fight against Alzheimer's disease, according to a new study by University of Alberta chemists. "Immune cells in the brain, called microglia, play a ...

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Turning 'junk' DNA into gold

New protein targets for drug development against prostate cancer

19-Nov-2019

Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer. Using state-of-the-art, whole-genome sequencing technologies on prostate tumour samples, ...

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Cancer treatment: A researcher makes breakthrough immunotherapy discovery

28-Oct-2019

Dr Christopher E. Rudd, a researcher at the Centre de recherche de l'Hôpital Maisonneuve-Rosemont (CR-HMR) and Université de Montréal, has discovered a new cell therapy approach that boosts the immune response of T lymphocytes to malignant tumours. "Our work has identified a new T-cell protein ...

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Improving research with more effective antibodies

Scientists demonstrate flaws in protein detection tools, and outline a solution

17-Oct-2019

A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly. Antibodies are used in laboratories and clinics to study proteins, which are the biomolecules that translate information from ...

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New piece of Alzheimer's puzzle found

Two short strings of amino acids could pave the way to new treatments for Alzheimer's disease

19-Sep-2019

Two years after discovering a way to neutralize a rogue protein linked to Alzheimer's disease, University of Alberta Distinguished University Professor and neurologist Jack Jhamandas has found a new piece of the Alzheimer's puzzle, bringing him closer to a treatment for the disease. In a study ...

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Bacteria-killing gel heals itself while healing you

30-Jul-2019

McMaster researchers have developed a novel new gel made entirely from bacteria-killing viruses. The anti-bacterial gel, which can be targeted to attack specific forms of bacteria, holds promise for numerous beneficial applications in medicine and environmental protection. Among many ...

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