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Turning 'junk' DNA into gold

New protein targets for drug development against prostate cancer

19-Nov-2019

Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer. Using state-of-the-art, whole-genome sequencing technologies on prostate tumour samples, ...

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Cancer treatment: A researcher makes breakthrough immunotherapy discovery

28-Oct-2019

Dr Christopher E. Rudd, a researcher at the Centre de recherche de l'Hôpital Maisonneuve-Rosemont (CR-HMR) and Université de Montréal, has discovered a new cell therapy approach that boosts the immune response of T lymphocytes to malignant tumours. "Our work has identified a new T-cell protein ...

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Improving research with more effective antibodies

Scientists demonstrate flaws in protein detection tools, and outline a solution

17-Oct-2019

A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly. Antibodies are used in laboratories and clinics to study proteins, which are the biomolecules that translate information from ...

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New piece of Alzheimer's puzzle found

Two short strings of amino acids could pave the way to new treatments for Alzheimer's disease

19-Sep-2019

Two years after discovering a way to neutralize a rogue protein linked to Alzheimer's disease, University of Alberta Distinguished University Professor and neurologist Jack Jhamandas has found a new piece of the Alzheimer's puzzle, bringing him closer to a treatment for the disease. In a study ...

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Bacteria-killing gel heals itself while healing you

30-Jul-2019

McMaster researchers have developed a novel new gel made entirely from bacteria-killing viruses. The anti-bacterial gel, which can be targeted to attack specific forms of bacteria, holds promise for numerous beneficial applications in medicine and environmental protection. Among many ...

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Can gut infection trigger Parkinson's disease?

22-Jul-2019

A new study by Montreal scientists published in Nature demonstrates that a gut infection can lead to a pathology resembling Parkinson's disease (PD) in a mouse model lacking a gene linked to the human disease. This discovery extends recent work by the same group suggesting that PD has a major ...

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Detecting bacteria in space

24-May-2019

Scientists at Université de Montréal and McGill University have pioneered and tested a new genomic methodology which reveals a complex bacterial ecosystem at work on the International Space Station. Their study is published today in Environmental Microbiology. Until now, relatively little was ...

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Researchers create nano-bot to probe inside human cells

15-Mar-2019

University of Toronto Engineering researchers have built a set of magnetic 'tweezers' that can position a nano-scale bead inside a human cell in three dimensions with unprecedented precision. The nano-bot has already been used to study the properties of cancer cells, and could point the way ...

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Merck Awarded Canadian CRISPR Nickase Patent for Foundational Genome-Editing Technology

05-Mar-2019

Merck announced that the Canadian Patent Office has allowed Merck’s patent application directed to the use of paired CRISPR nickases in eukaryotic cells. The patent provides an important and more specific solution for scientists who need accurate methods when developing treatments for ...

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Cross-species cancer comparison uncovers new drug targets

Drug targets for a form of melanoma from genetic mutations found in humans, dogs and horses

13-Feb-2019

New drug targets for a rare form of melanoma may result from the discovery of similar genetic mutations found in humans, dogs and horses under a first-ever tri-species DNA sequencing study involving a University of Guelph researcher. Melanoma is a cancer that most commonly occurs in the skin in ...

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