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25,101 Current news

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Transgenic T cells against malignant brain tumors

New form of therapy tested

29-Sep-2023 - Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time. Glioblastomas are the most aggressive of all brain tumors. They spread diffusely in ...

adoptive T cell therapy brain brain tumors +5
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Imaging the smallest atoms provides insights into an enzyme's unusual biochemistry

This could help in the design of enzymes for the chemical industry

29-Sep-2023 - When your wounds heal and your liver detoxifies a poison such as histamine you ingested, you can thank the class of enzymes known as copper amine oxidases for their assistance. Identifying the exact positions of the smallest hydrogen atoms in these enzymes is challenging with commonly used ...

artificial enzymes biochemistry crystallography +3
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Obesity as a risk factor for colorectal cancer underestimated so far

Weight loss before diagnosis masks the association

29-Sep-2023 - Obesity is a known risk factor for colorectal cancer. Scientists at the German Cancer Research Center (DKFZ) have now demonstrated, using data from nearly half a million participants in the UK Biobank cohort, that this association has probably been significantly underestimated to date. The ...

adipositas cancer colorectal cancer +3
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Merck to Become First Provider to Offer Fully Integrated mRNA Services

New sites at Darmstadt and Hamburg complement Merck’s global integrated mRNA service network

28-Sep-2023 - Merck became the first CTDMO (contract testing, development and manufacturing organization) to offer integrated services for all critical stages of mRNA development, manufacturing, and commercialization, including products and testing. The company opened two new GMP-grade mRNA drug substance ...

contract development contract manufacturing contract testing +3
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Double Trouble: Infamous “Eagle Killer” Bacterium Produces Not One, But Two Toxins

The new findings could help develop new drugs that fight cancer

28-Sep-2023 - The cyanobacterium Aetokthonos hydrillicola produces not just one, but two highly potent toxins. In the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), an international team led by Martin Luther University Halle-Wittenberg (MLU) and Freie Universität Berlin ...

Aetokthonos hydrillicola cancer cyanobacteria +1
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A close-up of biological nanomachines

Researchers take a deep look at peroxisomal processes

28-Sep-2023 - Every system has its waste disposal system. The cell organelles known as “peroxisomes” dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The “Pex” group of proteins (peroxisomes biogenesis factors) keep these “detox units” ...

cell organelles cells cryo-electron microscopy +1
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EXIST funding for innovation in biomedicine

Start-up aims to revolutionize the usage of magnetic nanoparticles

28-Sep-2023 - The project BioMagnetix aims to revolutionize the usage of magnetic nanoparticles in biomedicine. It has now received EXIST start-up funding from the Federal Ministry for Economic Affairs and Climate Action.With a grant of approx. 150,000 Euros, first steps to commercialize the idea can now be ...

bacteria biomedicine contrast agents +4
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Decreasing biodiversity may promote spread of viruses

New insight into the dynamics of infectious disease

28-Sep-2023 - How are environmental changes, loss of biodiversity, and the spread of pathogens connected? The answer is a puzzle. Researchers from Charité – Universitätsmedizin Berlin have now described one piece of that puzzle in the journal eLife,* showing that the destruction of tropical rainforests harms ...

biodiversity infections infectious diseases +4
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A taste for plastic

Discovered for the first time: New deep-sea enzyme breaks down PET plastic

27-Sep-2023 - Plastic pollution is increasingly affecting the health of coasts and oceans. One well-known problem is plastic bottles made from polyethylene terephthalate, or PET. A new study involving scientists from Professor Ruth Schmitz-Streit's research group at Kiel University has shown for the first ...

archaea biochemistry biotechnology +6
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Can coffee improve memory?

Findings suggest the efficacy of Trigonelline derived from coffee in preventing and improving age-related spatial learning memory impairment

27-Sep-2023 - The search for functional natural compounds that can improve age-related cognitive decline has recently emerged as an important research focus to promote healthy aging. Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess ...

alkaloids coffee cognitive functions +1