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Synapses consist of hundreds of different proteins. For correct transmission of brain signals, their building blocks must constantly be checked for functionality and replaced by new ones. A team of researchers from the Leibniz Institute of Neurobiology Magdeburg, the German Centre for Neurodegenerat more
An interdisciplinary team from the Institute of Radiopharmaceutical Cancer Research headed by Prof. Peter Brust has won HZDR’s (Helmholtz-Zentrum Dresden-Rossendorf) third Innovation Contest. The researchers succeeded in developing a new substance that could improve image-based differential diagnost more
Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master. A study by more
Celardi et al. "Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease" Cell Death and Disease (2016). doi:10.1038/cddis.2016.173 more
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative more
Maksim Fomich is currently looking into creating deuterated polyunsaturated fatty acid compounds, with a view to using them to potentially treat a range of diseases. Here, he shows the premise behind his research. A description of his research can be read via the link on the right side. more
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum. Although details of the molecular mechanisms underlying dopaminergic neuronal death in PD remain un more
Abstract FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed ‘DIV’ for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperat more
Abstract Background To investigate the diagnostic utility of signal intensity measurement of the substantia nigra pars compacta (SNc) using three dimensional (3D) neuromelanin‐sensitive 31MRI, for discrimination of patients with PD from healthy controls. Methods T1‐weighted neuromelanin more
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