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A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the f more
Researchers of Sechenov University and University of Pittsburgh described the most promising strategies in applying genetic engineering for studying and treating Parkinson's disease. This method can help evaluate the role of various cellular processes in pathology progression, develop new drugs and more
F.-Ulrich Hartl, Director at the Max Planck Institute of Biochemistry in Martinsried, is awarded the Breakthrough Prize in Life Sciences 2020 together with Arthur L. Horwich of Yale School of Medicine/HHMI. They are honored for discovering functions of molecular chaperones in mediating protein foldi more
Celardi et al. "Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease" Cell Death and Disease (2016). doi:10.1038/cddis.2016.173 more
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative more
Maksim Fomich is currently looking into creating deuterated polyunsaturated fatty acid compounds, with a view to using them to potentially treat a range of diseases. Here, he shows the premise behind his research. A description of his research can be read via the link on the right side. more
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum. Although details of the molecular mechanisms underlying dopaminergic neuronal death in PD remain un more
Abstract FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed ‘DIV’ for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperat more
Abstract Background To investigate the diagnostic utility of signal intensity measurement of the substantia nigra pars compacta (SNc) using three dimensional (3D) neuromelanin‐sensitive 31MRI, for discrimination of patients with PD from healthy controls. Methods T1‐weighted neuromelanin more
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