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At first glance, Down syndrome (DS) and Alzheimer's disease (AD), two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized--a triplication of chromosome 21. By contrast, the overwhelming majority of Alzheim more
Diagnosing Alzheimer's disease can be difficult, as several other conditions can cause similar symptoms. Now a new brain imaging method can show the spread of specific tau protein depositions, which are unique to cases with Alzheimer's. "The method works very well. I believe it will be applied clini more
A new study from The University of Texas Medical Branch at Galveston has uncovered why some people that have brain markers of Alzheimer’s never develop the classic dementia that others do. Alzheimer’s disease, the most common form of dementia, affects more than 5 million Americans. People suffering more
Nothing works without the correct form: For most proteins, there are millions of ways in which these molecules, composed of long chains of amino acids, can be folded - but only one way is the right one. Researchers in the department "Cellular Biochemistry" at the Max Planck Institute for Biochem ... more
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative more
Preclinical development of drug candidates for Alzheimer’s disease (AD) takes multiple different paths; animal models are indispensable tools to support diverse preclinical drug development programs. Charles River performs in-house evaluations employing several mouse models of AD using a range of up
The aggregation of the amyloid-β (Aβ) peptide into amyloid fibrils is associated with Alzheimer’s disease, and several point mutations leading to early-onset disease have been identified in Aβ. By studying the aggregation of five disease-related mutations in vitro, we rationalize their link to famil more
by Nicolas Henry, Eva-Maria Krammer, Florian Stengel, Quentin Adams, François Van Liefferinge, Ellen Hubin, Rui Chaves, Rouslan Efremov, Ruedi Aebersold, Guy Vandenbussche, Martine Prévost, Vincent Raussens, Stéphanie Deroo Apolipoprotein E (apoE) is a forefront actor in the transport of lipids a more
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer’s disease. It is unclear which tau residues are crucial for tau-MT inter more
Introduction GlobalData’s pharmaceuticals report, “Exelon (Alzheimer’s disease) – Analysis and Forecasts to 2022” provides Exelon global sales estimates. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sales perf more
Introduction GlobalData's clinical trial report, “Alzheimer’s Disease Global Clinical Trials Review, H2, 2012" provides data on the Alzheimer’s Disease clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Alzheimer’s Disease. It includes a more
Introduction GlobalData’s pharmaceuticals report, “LY2062430 (Alzheimer’s disease) – Analysis and Forecasts to 2022” provides LY2062430 global sales estimates. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sale more
Alzheimer's disease Alzheimer's disease (AD), also called Alzheimer disease, and simply known as Alzheimer's, is a neurodegenerative disease that, in its most common form, is found in people over the age of 65. Approximately 24 million people ... more
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