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10.924 Aktuelle Fachpublikationen zum Thema Stress

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Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

21.06.2018 | Daniel Pletzer; Sarah C. Mansour; Robert E. W. Hancock, PLoS Pathogens, 2018

by Daniel Pletzer, Sarah C. Mansour, Robert E. W. Hancock With the antibiotic development pipeline running dry, many fear that we might soon run out of treatment options. High-density infections are particularly difficult to treat due to their adaptive multidrug-resistance and currently there ...

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Energies, Vol. 11, Pages 1607: The Effect of a Vertical Electric Field on the Surface Flashover Characteristics of a Bushing Model

20.06.2018 | Zhu, Mingxi ; Wang, Liming ; Yin, Fanghui ; Farzaneh, Masoud ; Mei, Hongwei ; Wen, Lu, Energies, 2018

Energies, Vol. 11, Pages 1607: The Effect of a Vertical Electric Field on the Surface Flashover Characteristics of a Bushing Model Energies doi: 10.3390/en11061607 Authors: Mingxi Zhu Liming Wang Fanghui Yin Masoud Farzaneh Hongwei Mei Lu Wen High-voltage bushings play a ...

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A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa

20.06.2018 | Lalanthi Ratnayake; Keyur K. Adhvaryu; Elizabeth Kafes; Kamyar Motavaze; Patricia Lakin-Thomas, PLoS Genetics, 2018

by Lalanthi Ratnayake, Keyur K. Adhvaryu, Elizabeth Kafes, Kamyar Motavaze, Patricia Lakin-Thomas The TOR (Target of Rapamycin) pathway is a highly-conserved signaling pathway in eukaryotes that regulates cellular growth and stress responses. The cellular response to amino acids or carbon ...

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A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus [Medical Sciences]

19.06.2018 | Daniela Castanotto; Xiaowei Zhang; Jessica Alluin; Xizhe Zhang; Jacqueline Rüger; Brian Armstrong; John Rossi; Arthu ..., Proceedings of the National Academy of Sciences current issue, 2018

The deregulation of miRNA function is critical in the pathogenesis of cancer and other diseases. miRNAs and other noncoding RNAs (ncRNAs) tightly regulate gene expression, often in the cell nucleus. Heretofore, there has been no understanding that there exists a general shuttling mechanism that ...

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Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response [Microbiology]

19.06.2018 | Elias R. Gerrick; Thibault Barbier; Michael R. Chase; Raylin Xu; Josie François; Vincent H. Lin; Matthew J. Szucs; J ..., Proceedings of the National Academy of Sciences current issue, 2018

This work describes the most extensive discovery and functional characterization of small regulatory RNAs (sRNAs) in Mycobacterium tuberculosis to date. We comprehensively define the sRNAs expressed in M. tuberculosis under five host-like stress conditions. This reference dataset comprehensively ...

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Facing your fears

15.06.2018 | Paul W. Frankland; Sheena A. Josselyn, Science , 2018

Remembering traumatic fearful events is adaptive. However, treating no-longer-threatening situations as dangerous may be maladaptive and lead to anxiety disorders, including phobias and posttraumatic stress disorder. Central to many forms of therapy designed to tackle these anxiety disorders is ...

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Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

15.06.2018 | Arnaud Pommier; Naishitha Anaparthy; Nicoletta Memos; Z. Larkin Kelley; Alizée Gouronnec; Ran Yan; Cédric Auffray; J ..., Science , 2018

The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers from patients and mice with PDA harbor single disseminated cancer cells (DCCs) lacking expression of cytokeratin 19 (CK19) and major ...

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Genome-wide characterization and expression analysis of citrus NUCLEAR FACTOR-Y (NF-Y) transcription factors identified a novel NF-YA gene involved in drought-stress response and tolerance

15.06.2018 | Suzam L. S. Pereira; Cristina P. S. Martins; Aurizangela O. Sousa; Luciana R. Camillo; Caroline P. Araújo; Grazielle ..., PLoS ONE, 2018

by Suzam L. S. Pereira, Cristina P. S. Martins, Aurizangela O. Sousa, Luciana R. Camillo, Caroline P. Araújo, Grazielle M. Alcantara, Danielle S. Camargo, Luciana C. Cidade, Alex-Alan F. de Almeida, Marcio G. C. Costa Nuclear factor Y (NF-Y) is a ubiquitous transcription factor found in ...

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Evidence for a second regulatory binding site on PspF that is occupied by the C-terminal domain of PspA

15.06.2018 | Eyleen Sabine Heidrich; Thomas Brüser, PLoS ONE, 2018

by Eyleen Sabine Heidrich, Thomas Brüser PspA is a key component of the bacterial Psp membrane-stress response system. The biochemical and functional characterization of PspA is impeded by its oligomerization and aggregation properties. It was recently possible to solve the coiled coil ...

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Ligament, hinge, and shell cross-sections of the Atlantic surfclam (Spisula solidissima): Promising marine environmental archives in NE North America

14.06.2018 | Pierre Poitevin; Julien Thébault; Bernd R. Schöne; Aurélie Jolivet; Pascal Lazure; Laurent Chauvaud, PLoS ONE, 2018

by Pierre Poitevin, Julien Thébault, Bernd R. Schöne, Aurélie Jolivet, Pascal Lazure, Laurent Chauvaud The Atlantic surfclam (Spisula solidissima) is a commercially important species in North American waters, undergoing biological and ecological shifts. These are attributed, in part, to ...

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