01.07.2018 | Gaëlle J.S. Talhouarne; Joseph G. Gall, RNA, 2018

We report that 7SL, the RNA component of the signal recognition particle (SRP), is an abundant noncoding RNA (ncRNA) in mature red blood cells (RBCs) of human, mouse, and the frog Xenopus. 7SL RNA in RBCs is not associated with the canonical proteins of the SRP. Instead, it coimmunoprecipitates ...

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01.07.2018 | Malik Chaker-Margot, RNA, 2018

The eukaryotic ribosome is made of four intricately folded ribosomal RNAs and 79 proteins. During rapid growth, yeast cells produce an incredible 2000 ribosomes every minute. Ribosome assembly involves more than 200 trans-acting factors, intervening from the transcription of the preribosomal RNA ...

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01.07.2018 | Samuele Negro; Marco Stazi; Marta Marchioretto; Toma Tebaldi; Umberto Rodella; Elisa Duregotti; Volker Gerke; Alessa ..., RNA, 2018

Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) is a ...

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29.06.2018 | Caroline Ash; Jesse Smith; Stella M. Hurtley, Science , 2018

Cell Biology Recently, several proteins have been shown to phase-separate into liquid droplets within the cell. Dine et al. found that such protein droplets exhibit a robust form of spatial memory. The droplets maintained the spatial pattern of an inhibitor of droplet formation long after the

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29.06.2018 | Rui Bai; Ruixue Wan; Chuangye Yan; Jianlin Lei; Yigong Shi, Science , 2018

The precatalytic spliceosome (B complex) is preceded by the pre-B complex. Here we report the cryo–electron microscopy structures of the Saccharomyces cerevisiae pre-B and B complexes at average resolutions of 3.3 to 4.6 and 3.9 angstroms, respectively. In the pre-B complex, the duplex between ...

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29.06.2018 | Yann Thomas; Daniel C. Scott; Yosua Adi Kristariyanto; Jesse Rinehart; Kristopher Clark; Philip Cohen; Thimo Kurz, PLoS ONE, 2018

by Yann Thomas, Daniel C. Scott, Yosua Adi Kristariyanto, Jesse Rinehart, Kristopher Clark, Philip Cohen, Thimo Kurz The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is ...

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29.06.2018 | Yotsu-Yamashita, Mari ; Nagaoka, Yuuma ; Muramoto, Koji ; Cho, Yuko ; Konoki, Keiichi, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 224: Pufferfish Saxitoxin and Tetrodotoxin Binding Protein (PSTBP) Analogues in the Blood Plasma of the Pufferfish Arothron nigropunctatus, A. hispidus, A. manilensis, and Chelonodon patoca Marine Drugs doi: 10.3390/md16070224 Authors: Mari ...

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28.06.2018 | Kathrin K. Geyer; Sabrina E. Munshi; Helen L. Whiteland; Narcis Fernandez-Fuentes; Dylan W. Phillips; Karl F. Hoffmann, PLoS Pathogens, 2018

by Kathrin K. Geyer, Sabrina E. Munshi, Helen L. Whiteland, Narcis Fernandez-Fuentes, Dylan W. Phillips, Karl F. Hoffmann While schistosomiasis remains a significant health problem in low to middle income countries, it also represents a recently recognised threat to more economically-developed ...

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27.06.2018 | Yuan, Yuan ; Zhang, Zhi-Peng ; He, Yi-Ning ; Fan, Wen-Sheng ; Dong, Zhi-Hua ; Zhang, Li-Hua ; Sun, Xin-Kuan ; Song, ..., Viruses, 2018

Viruses, Vol. 10, Pages 347: Protection against Virulent Infectious Bronchitis Virus Challenge Conferred by a Recombinant Baculovirus Co-Expressing S1 and N Proteins Viruses doi: 10.3390/v10070347 Authors: Yuan Yuan Zhi-Peng Zhang Yi-Ning He Wen-Sheng Fan Zhi-Hua Dong Li-Hua ...

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26.06.2018 | Takashi Ishii; Hiroshi Hayakawa; Tatsuhiro Igawa; Takeshi Sekiguchi; Mutsuo Sekiguchi, Proceedings of the National Academy of Sciences current issue, 2018

The binding of human PCBP1 protein to heavily oxidized RNA triggers the induction of apoptosis-related reactions, including the activation of caspase-3 and the cleavage of PARP-1. The introduction of amino acid substitutions in the PCBP1 abolishes this, resulting in the failure of PARP-1 ...

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