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66 Aktuelle Fachpublikationen zum Thema Peptide

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Design, Synthesis, and Biological Evaluation of New Peptide Analogues as Selective COX‐2 Inhibitors

05.09.2017 | Mohammad A. Ahmaditaba, Soraya Shahosseini, Bahram Daraei, Afshin Zarghi, Mohammad H. Houshdar Tehrani, Archiv der Pharmazie, 2017

A new class of peptide derivatives possessing SO2Me and N3 pharmacophores at the para position of a phenyl ring bound to different aromatic amino acids were synthesized based on solid‐phase synthesis methodology, and evaluated as selective cyclooxygenase‐2 (COX‐2) inhibitors. One of the ...

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Molecular Reproduction & Development Volume 84, Issue 8, August 2017

21.08.2017 | Molecular Reproduction and Development, 2017

Oviductal fl uid fl ow is important for the transport of gametes and embryos. Each ciliated epithelial cell has 200–300 cilia, and their continuous beating generates unidirectional fl ow of oviductal fl uid. Yoshimoto et al. (this issue) report that Adrenomedullin, a peptide hormone belonging ...

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Chemical Glycosylation of Peptides

01.08.2017 | Jyothi Thundimadathil, Chris McGee, pharmind, 2017

Whereas recombinant synthesis of glycosylated peptides and proteins yields heterogeneous products, homogeneous glycoforms with potential for better defined bioactivity can be obtained by complex chemical methods. A new technology permits straightforward selective glycosylation via incorporation ...

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Adrenomedullin regulates the speed of oviductal fluid flow in cattle

16.06.2017 | Yuka Yoshimoto, Takumi Nishie, Sayaka Ito, Yoshihiko Kobayashi, Yuki Yamamoto, Kiyoshi Okuda, Koji Kimura, Molecular Reproduction and Development, 2017

Abstract Unidirectional flow of oviductal fluid from the ovarian to uterine side of the ampulla plays a significant role in successful pregnancy, and is produced by ciliary beating. Various systems regulate ciliary beating, such as paracrine, autocrine, and endocrine. We hypothesized that ...

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Anti‐Inflammatory Effects of PEGylated Human Adrenomedullin in a Mouse DSS‐Induced Colitis Model

27.04.2017 | Sayaka Nagata, Motoo Yamasaki, Kazuo Kitamura, Drug Development Research, 2017

ABSTRACT Human adrenomedullin (hAM), a hypotensive peptide, also has anti‐inflammatory effects. hAM can reduce the severity of the dextran sulphate sodium (DSS)‐ and 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced colitis in animal models. Furthermore, in a clinical study, hAM ...

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Adrenomedullin – new perspectives of a potent peptide hormone

02.02.2017 | Ria Schönauer, Sylvia Els‐Heindl, Annette G. Beck‐Sickinger, Journal of Peptide Science, 2017

Adrenomedullin (ADM) is a 52‐amino acid multifunctional peptide, which belongs to the calcitonin gene‐related peptide (CGRP) superfamily of vasoactive peptide hormones. ADM exhibits a significant vasodilatory potential and plays a key role in various regulatory mechanisms, predominantly in the ...

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Dysregulation of MAP Kinase Signaling Pathways Including p38MAPK, SAPK/JNK, and ERK1/2 in Cultured Rat Cerebellar Astrocytes Exposed to Diphenylarsinic Acid

13.01.2017 | Negishi T, Matsumoto M, Kobayashi Y, et al., Toxicological Sciences, 2017

AbstractDiphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported ...

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Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues

14.12.2016 | Jakub Faktor, Rita Suchá, Vendula Páralová, Yansheng Liu, Pavel Bouchal, PROTEOMICS, 2016

Targeted mass spectrometry‐based proteomics approaches enable the simultaneous and reproducible quantification of multiple protein analytes across numerous conditions in biology and clinical studies. These approaches involve e.g. selected reaction monitoring (SRM) typically conducted on a triple ...

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Production and application of high quality stable isotope labeled human immunoglobulin G1 for mass spectrometry analysis

12.12.2016 | Philipp Amsler, Wolf Thierry, Lanshoeft Christian, Bettighofer Anja, Eisfeld Jochen, Moenius Thomas, Probst Claudia, ..., Journal of Labelled Compounds and Radiopharmaceuticals, 2016

Here we describe the production of stable isotope labeled human immunoglobulin G1 ([13C]‐hIgG1) using [13C]‐L‐lysine/arginine labeled‐hIgG1. The fermentation process was run in shake flasks containing labeled arginine (Arg) and lysine (Lys) which were incorporated into the produced recombinant ...

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Improved 68Ga‐labeling method using ethanol addition: Application to the α‐helical peptide DOTA‐FAMP

07.12.2016 | Koki Hasegawa, Emi Kawachi, Yoshinari Uehara, Tsuyoshi Yoshida, Satoshi Imaizumi, Masahiro Ogawa, Shin‐ichiro Miura, ..., Journal of Labelled Compounds and Radiopharmaceuticals, 2016

We examined the 68Ga labeling of the α‐helical peptide, DOTA‐FAMP, and evaluated conformational changes during radiolabeling. 68Ga‐DOTA‐FAMP is a positron emission tomography probe candidate for atherosclerotic plaques. The labeling yield achieved by Zhernosekov's method (using acetone for 68Ga ...

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