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433 Aktuelle Fachpublikationen zum Thema Hormone


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A noncanonical PPAR{gamma}/RXR{alpha}-binding sequence regulates leptin expression in response to changes in adipose tissue mass [Medical Sciences]

26.06.2018 | Yinxin Zhang; Olof Stefan Dallner; Tomoyoshi Nakadai; Gulya Fayzikhodjaeva; Yi-Hsueh Lu; Mitchell A. Lazar; Robert G ..., Proceedings of the National Academy of Sciences current issue, 2018

Leptin gene expression is highly correlated with the lipid content of individual fat cells, suggesting that it is regulated by a “fat-sensing” signal transduction pathway. This possibility is thus analogous to the identification of a cholesterol-sensing pathway by studying the regulation of the ...


Marine Drugs, Vol. 16, Pages 198: Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis

05.06.2018 | Pan, Haitao ; Fu, Chuhan ; Huang, Lanlan ; Jiang, Yao ; Deng, Xiaoyi ; Guo, Jiao ; Su, Zhengquan, Marine Drugs, 2018

Marine Drugs, Vol. 16, Pages 198: Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis Marine Drugs doi: 10.3390/md16060198 Authors: Haitao Pan Chuhan Fu Lanlan Huang Yao Jiang Xiaoyi Deng Jiao ...


Phosphorus restriction does not prevent the increase in fibroblast growth factor 23 elicited by high fat diet

01.06.2018 | Rafael Rios; Carmen Pineda; Ignacio Lopez; Juan Muñoz-Castañeda; Mariano Rodriguez; Escolastico Aguilera-Tejero; Ana ..., PLoS ONE, 2018

by Rafael Rios, Carmen Pineda, Ignacio Lopez, Juan Muñoz-Castañeda, Mariano Rodriguez, Escolastico Aguilera-Tejero, Ana I. Raya This study was designed to evaluate the influence of phosphorus (P) restriction on the deleterious effects of high fat diets on mineral metabolism. Twenty-four rats ...


Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin

22.05.2018 | Remco Bredewold; Nara F. Nascimento; Grace S. Ro; Shannon E. Cieslewski; Christina J. Reppucci; Alexa H. Veenema, Neuropsychopharmacology, 2018

Social play is a highly rewarding behavior displayed mostly during the juvenile period. We recently showed that vasopressin V1a receptor (V1aR) blockade in the lateral septum (LS) enhances social play in male juvenile rats, but reduces it in females. Here, we determined whether the LS-AVP system ...


Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats

17.05.2018 | Thanuja Gali Ramamoorthy; Tiffany-Jayne Allen; Alison Davies; Erika Harno; Charlotte Sefton; Christopher Murgatroyd; ..., International Journal of Obesity, 2018

Maternal overnutrition has been implicated in affecting the offspring by programming metabolic disorders such as obesity and diabetes, by mechanisms that are not clearly understood. This study aimed to determine the long-term impact of maternal high-fat (HF) diet feeding on epigenetic changes in ...


Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

30.04.2018 | Taka-aki Koshimizu; Kenji Honda; Sachi Nagaoka-Uozumi; Atsuhiko Ichimura; Ikuo Kimura; Michio Nakaya; Nobuya Sakai; ..., Nature Neuroscience, 2018

Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice ...


Biological and psychological mediators of the relationships between fat mass, fat-free mass and energy intake

13.03.2018 | Mark Hopkins; Graham Finlayson; Cristiana Duarte; Catherine Gibbons; Alexandra M Johnstone; Stephen Whybrow; Graham ..., International Journal of Obesity, 2018

While recent studies in humansindicate that fat-free mass (FFM) is closely associated with energy intake (EI) when in energy balance, associations between fat mass (FM) and EI are inconsistent. The present study used a cross-sectional design to examine the indirect and direct effects of FFM, FM ...


Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism

09.03.2018 | Natalie K. Y. Wee; Ronaldo F. Enriquez; Amy D. Nguyen; Harry Horsnell; Rishikesh Kulkarni; Ee Cheng Khor; Herbert He ..., International Journal of Obesity, 2018

To determine whether age and neuropeptide Y (NPY) were involved in the skeletal response to extended periods of diet-induced obesity. Male wild-type (WT) and NPY null (NPYKO) mice were fed a mild (23% fat) high-fat diet for 10 weeks from 6 or 16 weeks of age. Metabolism and bone density were ...


Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis

09.03.2018 | Virginie-Anne Chouinard; David C. Henderson; Chiara Dalla Man; Linda Valeri; Brianna E. Gray; Kyle P. Ryan; Aaron M. ..., Molecular Psychiatry, 2018

Patients with psychotic disorders are at high risk for type 2 diabetes mellitus, and there is increasing evidence that patients display glucose metabolism abnormalities before significant antipsychotic medication exposure. In the present study, we examined insulin action by quantifying insulin ...


Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency

27.02.2018 | Katja Kohlsdorf; Adriana Nunziata; Jan-Bernd Funcke; Stephanie Brandt; Julia Schnurbein; Heike Vollbach; Belinda Len ..., International Journal of Obesity, 2018

To evaluate whether early childhood body mass index (BMI) is an appropriate indicator for monogenic obesity. A cohort of n = 21 children living in Germany or Austria with monogenic obesity due to congenital leptin deficiency (group LEP, n = 6), leptin receptor deficiency (group LEPR, n = 6) and ...


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