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2.506 Aktuelle Fachpublikationen zum Thema Flüssigchromatographie

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In vitro anthelmintic effects of Spigelia anthelmia protein fractions against Haemonchus contortus

15.12.2017 | Sandra Alves Araújo; Alexandra Martins dos Santos Soares; Carolina Rocha Silva; Eduardo Bezerra Almeida Júnior; Cláu ..., PLoS ONE, 2017

by Sandra Alves Araújo, Alexandra Martins dos Santos Soares, Carolina Rocha Silva, Eduardo Bezerra Almeida Júnior, Cláudia Quintino Rocha, André Teixeira da Silva Ferreira, Jonas Perales, Livio M. Costa-Júnior Gastrointestinal nematodes are a significant concern for animal health and ...

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Structures and Antibacterial Properties of Isorugosins H–J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties

11.10.2017 | Yuuki Shimozu; Teruo Kuroda; Tomofusa Tsuchiya; Tsutomu Hatano, Journal of Natural Products, 2017

Three new ellagitannin oligomers, isorugosins H (1), I (2), and J (3), together with 11 known hydrolyzable tannins were isolated from an aqueous acetone extract of the fresh leaves of Liquidambar formosana. Their chemical structures were elucidated based on spectroscopic data and chemical ...

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Lorneic Acid Analogues from an Endophytic Actinomycete

09.10.2017 | Ruimin Yang; Jing Yang; Li Wang; Jian-Ping Huang; Zijun Xiong; Jianying Luo; Mingming Yu; Yijun Yan; Sheng-Xiong Huang, Journal of Natural Products, 2017

Our natural products discovery program utilizes endophytic actinomycetes associated with plants and employs biological assays and HPLC-based metabolite profiles as the preliminary screen to identify strains of interest, followed by large-scale fermentation and isolation, leading to new and/or ...

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Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance

24.09.2017 | Author(s): Michał Romański, Anna Kasprzyk, Mateusz Walczak, Agnieszka Ziółkowska, Franciszek Główka, European Journal of Pharmaceutical Science, 2017

Publication date: 15 November 2017 Source:European Journal of Pharmaceutical Sciences, Volume 109 Author(s): Michał Romański, Anna Kasprzyk, Mateusz Walczak, Agnieszka Ziółkowska, Franciszek Główka For the recent years, the application of treosulfan (TREO)-based conditioning prior ...

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Syzygium cumini seed exhibits antidiabetic potential via multiple pathways involving inhibition of α‐glucosidase, DPP‐IV, glycation, and ameliorating glucose uptake in L6 cell lines

21.09.2017 | Hari Priya Syama, Karthika Bahulayan Arun, George Sinumol, Rajendran Dhanya, Sasidharan Suseela Anusree, P. Nisha, L ..., Journal of Food Processing and Preservation, 2017

Abstract The present study evaluated antidiabetic potential of fractions of Syzygium cumini seeds and identified major polyphenolic compounds in them. Potential α‐glucosidase and α‐amylase inhibition (IC50 1.7 and 7.62μg/ml, respectively) was demonstrated by 70% methanol fraction while ...

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A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis

19.09.2017 | Amjad Ayad Qatran Al-Khdhairawi; Premanand Krishnan; Chun-Wai Mai; Felicia Fei-Lei Chung; Chee-Onn Leong; Kien-Thai ..., Journal of Natural Products, 2017

Tengerensine (1), isolated as a racemate and constituted from a pair of bis-benzopyrroloisoquinoline enantiomers, and tengechlorenine (2), purified as a scalemic mixture and constituted from a pair of chlorinated phenanthroindolizidine enantiomers, were isolated from the leaves of Ficus fistulosa ...

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D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP

18.09.2017 | Jia F, Wang J, Peng J, et al., Acta Biochimica et Biophysica Sinica, 2017

Abstract With the increasing emergence of resistant microbes toward conventional antimicrobial agents, there is an urgent need for the development of antimicrobial agents with novel action mode. Antimicrobial peptides (AMPs) are believed to be one kind of ideal alternatives. However, AMPs can be ...

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Novel Insights into the Inhibitory Effect and Mechanism of Proanthocyanidins from Pyracantha fortuneana Fruit on α‐Glucosidase

14.09.2017 | Mankun Wei, Wei‐Ming Chai, Qin Yang, Rui Wang, Yiyuan Peng, Journal of Food Science, 2017

Abstract Proanthocyanidins were extracted from Pyracantha fortuneana fruit (PFF), and their structures were investigated through 13C nuclear magnetic resonance (13C NMR), high performance liquid chromatography (HPLC) and high resolution mass spectrometry (HRMS). The results showed that these ...

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Simulated gastrointestinal digestion and in vitro colonic fermentation of date (Phoenix dactylifera L.) seed polyphenols

14.09.2017 | Sameera Sirisena, Said Ajlouni, Ken Ng, International Journal of Food Science & Technology, 2017

Summary Date seeds are a by‐product of date fruit industry and a rich source of polyphenols. In this study, invitro bioaccessibility and colonic fermentation of major polyphenols from date seed powder (DSP) and DSP‐fortified yoghurt (DSPY) were investigated using HPLC. Catechin, epicatechin ...

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Synthesis, Quality Control and Bio‐evaluation of 99mTc‐cyclophosphamide

08.09.2017 | Tanveer Hussain Bokhari, Samina Roohi, Saira Hina, Muhammad Usman Akbar, Muhammad Sohaib, Munawar Iqbal, Chemical Biology & Drug Design, 2017

Abstract Cancer is found to be the leading cause of death worldwide characterized by uncontrolled cell division. Nuclear medicines imaging by using radiopharmaceuticals have pronounced potential for the diagnosis and treatment of cancers. Cyclophosphamide (CPH) is an antineoplastic drug which ...

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