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43.056 Aktuelle Fachpublikationen zum Thema Expression

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Cued fear memory generalization increases over time [RESEARCH]

01.07.2018 | Gabrielle A. Pollack; Jessica L. Bezek; Serena H. Lee; Miranda J. Scarlata; Leah T. Weingast; Hadley C. Bergstrom, Learning & Memory, 2018

Fear memory is a highly stable and durable form of memory, even over vast (remote) time frames. Nevertheless, some elements of fear memory can be forgotten, resulting in generalization. The purpose of this study is to determine how cued fear memory generalizes over time and measure underlying ...

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Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation [ARTICLE]

01.07.2018 | Sarah J. Fletcher; Vera P. Pisareva; Abdullah O. Khan; Andrew Tcherepanov; Neil V. Morgan; Andrey V. Pisarev, RNA, 2018

Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently ...

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MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs [ARTICLE]

01.07.2018 | Jessica S. Kurata; Ren-Jang Lin, RNA, 2018

MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a ...

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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [ARTICLE]

01.07.2018 | Samuele Negro; Marco Stazi; Marta Marchioretto; Toma Tebaldi; Umberto Rodella; Elisa Duregotti; Volker Gerke; Alessa ..., RNA, 2018

Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) is a ...

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Subspace module extraction from MI-based co-expression network

29.06.2018 | Sarmistha Deb; Priyakshi Mahanta; Dhruba K. Bhattacharyya; Malay Ananda Dutta, International Journal of Bioinformatics Research and Applications, 2018

Subspace module extraction from MI-based co-expression networkSarmistha Deb; Priyakshi Mahanta; Dhruba K. Bhattacharyya; Malay Ananda DuttaInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 207 - 234Most of the existing methods in literature have used ...

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Altered circadian genes expression in breast cancer tissue according to the clinical characteristics

29.06.2018 | Monika Lesicka; Ewa Jabłońska; Edyta Wieczorek; Barbara Seroczyńska; Anna Siekierzycka; Jarosław Skokowski; Leszek K ..., PLoS ONE, 2018

by Monika Lesicka, Ewa Jabłońska, Edyta Wieczorek, Barbara Seroczyńska, Anna Siekierzycka, Jarosław Skokowski, Leszek Kalinowski, Wojciech Wąsowicz, Edyta Reszka Breast cancer has a multifactorial etiology. One of the supposed and novel mechanisms is an alteration of circadian gene expression. ...

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Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

29.06.2018 | Rumela Chakrabarti; Toni Celià-Terrassa; Sushil Kumar; Xiang Hang; Yong Wei; Abrar Choudhury; Julie Hwang; Jia Peng; ..., Science , 2018

The stem cell niche is a specialized environment that dictates stem cell function during development and homeostasis. We show that Dll1, a Notch pathway ligand, is enriched in mammary gland stem cells (MaSCs) and mediates critical interactions with stromal macrophages in the surrounding niche in ...

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Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

29.06.2018 | Miguel Rodríguez Pulido; María Teresa Sánchez-Aparicio; Encarnación Martínez-Salas; Adolfo García-Sastre; Francisco ..., PLoS Pathogens, 2018

by Miguel Rodríguez Pulido, María Teresa Sánchez-Aparicio, Encarnación Martínez-Salas, Adolfo García-Sastre, Francisco Sobrino, Margarita Sáiz The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like receptors ...

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Molecular identification and functional characterization of the cathepsin B gene (Ab-cb-1) in the plant parasitic nematode Aphelenchoides besseyi

29.06.2018 | Hong-Le Wang; Xi Cheng; Shan-Wen Ding; Dong-Wei Wang; Chun Chen; Chun-Ling Xu; Hui Xie, PLoS ONE, 2018

by Hong-Le Wang, Xi Cheng, Shan-Wen Ding, Dong-Wei Wang, Chun Chen, Chun-Ling Xu, Hui Xie The rice white tip nematode, Aphelenchoides besseyi, is widely distributed in rice planting areas worldwide and causes serious economic losses. Cathepsin genes have been demonstrated to have importance in ...

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Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse

29.06.2018 | Charles E. Hay; Guillermo A. Gonzalez III; Laura E. Ewing; E. Elizabeth Reichard; Michael D. Hambuchen; Nisha Nanawa ..., PLoS ONE, 2018

by Charles E. Hay, Guillermo A. Gonzalez III, Laura E. Ewing, E. Elizabeth Reichard, Michael D. Hambuchen, Nisha Nanaware-Kharade, Sinthia Alam, Chris T. Bolden, S. Michael Owens, Paris Margaritis, Eric C. Peterson Methamphetamine (METH) substance abuse disorders have major impact on society, ...

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