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277 Aktuelle Fachpublikationen zum Thema Chromatographie


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Proteomic signature of circulating extracellular vesicles in dilated cardiomyopathy

14.03.2018 | Santiago Roura; Ana Gámez-Valero; Josep Lupón; Carolina Gálvez-Montón; Francesc E. Borràs; ..., Laboratory Investigation, 2018

Dilated cardiomyopathy (DCM) remains a major cause of heart failure and carries a poor prognosis despite important advances in recent years. Better disease characterization using novel molecular techniques is needed to refine its progression. This study explored the proteomic signature of ...


A long‐lived aβ oligomer resistant to fibrillization

10.01.2018 | Mimi Nick, Yibing Wu, Nathan W. Schmidt, Stanley B. Prusiner, Jan Stöhr, William F. DeGrado, Biopolymers, 2018

Abstract The hydrophobic Aβ peptide is highly aggregation prone; it first forms soluble oligomers, which then convert into the amyloid fibrils found in the cerebral plaques of Alzheimer's disease. It is generally understood that as the peptide concentration of Aβ increases, the fibrillization ...


Crystal structure of tetrameric human Rabin8 GEF domain

10.01.2018 | Melanie Vetter, Niels Boegholm, Anni Christensen, Sagar Bhogaraju, Marie B. Andersen, Anna Lorentzen, Esben Lorentzen, Proteins: Structure, Function, and Bioinformatics, 2018

Abstract Rab GTPases and their effectors, activators and guanine nucleotide exchange factors (GEFs) are essential for vesicular transport. Rab8 and its GEF Rabin8 function in formation of the cilium organelle important for developmental signaling and sensory reception. Here we show by size ...


Structures and Antibacterial Properties of Isorugosins H–J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties

11.10.2017 | Yuuki Shimozu; Teruo Kuroda; Tomofusa Tsuchiya; Tsutomu Hatano, Journal of Natural Products, 2017

Three new ellagitannin oligomers, isorugosins H (1), I (2), and J (3), together with 11 known hydrolyzable tannins were isolated from an aqueous acetone extract of the fresh leaves of Liquidambar formosana. Their chemical structures were elucidated based on spectroscopic data and chemical ...


Nitrilotriacetic Amine-Functionalized Polymeric Core–Shell Nanoparticles as Enzyme Immobilization Supports

15.08.2017 | Dominic Keller; Ana Beloqui; Mónica Martínez-Martínez; Manuel Ferrer; Guillaume Delaittre, Biomacromolecules, 2017

Nitrilotriacetic amine (NTA)-functionalized nanoparticles obtained by aqueous polymerization-induced self-assembly (PISA) are introduced as immobilization supports for polyhistidine-functionalized (His-tagged) enzymes. A novel initiator for nitroxide-mediated polymerization based on the nitroxide ...


Primum non nocere - the effects of sodium hypochlorite on dentin as used in endodontics

13.08.2017 | Author(s): Li-sha Gu, Xue-qing Huang, Brandon Griffin, Brian R. Bergeron, David H. Pashley, Li-na Niu, F ..., Acta Biomaterialia, 2017

Publication date: Available online 8 August 2017 Source:Acta Biomaterialia Author(s): Li-sha Gu, Xue-qing Huang, Brandon Griffin, Brian R. Bergeron, David H. Pashley, Li-na Niu, Franklin R. Tay The medical literature is replete with the maxim ‘primum non nocere’, cautioning ...


Characterization of a Cathepsin D Protease from CHO Cell‐Free Medium and Mitigation of its Impact on the Stability of a Recombinant Therapeutic Protein

20.07.2017 | Amareth Lim, Brandon L. Doyle, Gerard M. Kelly, Angelia M. Reed‐Bogan, Lawrence H. Breen, Parviz A. Shamlou, Peter K ..., Biotechnology Progress, 2017

Abstract During purification process development of a recombinant therapeutic protein, an endoproteolytic activity endogenous to the Chinese hamster ovary (CHO) cells and leading to degradation at particular hydrophobic amino acid residues (e.g., Phe and Trp) was observed when processing at ...


Marine Drugs, Vol. 15, Pages 220: Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus

11.07.2017 | Pisapia, Francesco ; Sibat, Manoëlla ; Herrenknecht, Christine ; Lhaute, Korian ; Gaiani, Greta ; Ferron, Pierre-Jea ..., Marine Drugs, 2017

Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, ...


Alzheimer's Disease-associated Aβ42 Peptide: Expression and Purification for NMR Structural Studies

13.06.2017 | Serra-Batiste, Montserrat; Garcia-Castellanos, Raquel; Ninot-Pedrosa, Marti; Serra-Vidal, Bernat; Simon Berrow, Nich ..., Chemical Biology, 2017

Abstract: Background: The aggregation of the amyloid-beta peptide (Aβ) in the brain is strongly associated with Alzheimer's disease (AD). However, the heterogeneous and transient nature of this process has prevented identification of the exact molecular form of Aβ responsible for the ...


Extrafibrillar collagen demineralization-based chelate-and-rinse technique bridges the gap between wet and dry dentin bonding

22.05.2017 | Author(s): Sui Mai, Chin-Chuan Wei, Li-sha Gu, Fu-cong Tian, Dwayne D. Arola, Ji-hua Chen, Yang Jiao, ..., Acta Biomaterialia, 2017

Publication date: Available online 9 May 2017 Source:Acta Biomaterialia Author(s): Sui Mai, Chin-Chuan Wei, Li-sha Gu, Fu-cong Tian, Dwayne D. Arola, Ji-hua Chen, Yang Jiao, David H. Pashley, Li-na Niu, Franklin R. Tay Limitations associated with wet-bonding led to the ...


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