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37.315 Aktuelle Fachpublikationen zum Thema cells

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Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier

01.07.2018 | Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes, European Journal of Pharmaceutical Science, 2018

Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes Pericytes are perivascular cells that play important roles in the regulation of the blood-brain barrier ...

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Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method

01.07.2018 | Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis, European Journal of Pharmaceutical Science, 2018

Publication date: 15 September 2018 Source:European Journal of Pharmaceutical Sciences, Volume 122 Author(s): S.M.T. Cavalcanti, C. Nunes, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis An adapted methodology for obtaining lipid nanoparticles that only uses the microwave reactor ...

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Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation [ARTICLE]

01.07.2018 | Sarah J. Fletcher; Vera P. Pisareva; Abdullah O. Khan; Andrew Tcherepanov; Neil V. Morgan; Andrey V. Pisarev, RNA, 2018

Platelets are anucleate and mostly ribosome-free cells within the bloodstream, derived from megakaryocytes within bone marrow and crucial for cessation of bleeding at sites of injury. Inherited thrombocytopenias are a group of disorders characterized by a low platelet count and are frequently ...

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MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs [ARTICLE]

01.07.2018 | Jessica S. Kurata; Ren-Jang Lin, RNA, 2018

MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a ...

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Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [ARTICLE]

01.07.2018 | Samuele Negro; Marco Stazi; Marta Marchioretto; Toma Tebaldi; Umberto Rodella; Elisa Duregotti; Volker Gerke; Alessa ..., RNA, 2018

Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance. At the murine neuromuscular junction, hydrogen peroxide (H2O2) is a ...

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Computer aided detection and classification of Pap smear cell images using principal component analysis

30.06.2018 | Ponnusamy Sukumar; Samikannu Ravi, International Journal of Bio-Inspired Computation, 2018

Computer aided detection and classification of Pap smear cell images using principal component analysisPonnusamy Sukumar; Samikannu RaviInternational Journal of Bio-Inspired Computation, Vol. 11, No. 4 (2018) pp. 257 - 266Pap smear is a screening methodology employed in cervix cancer detection ...

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Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

30.06.2018 | Menotti, Laura ; Avitabile, Elisa ; Gatta, Valentina ; Malatesta, Paolo ; Petrovic, Biljana ; Campadelli-Fiume, Gabr ..., Viruses, 2018

Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella ...

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The power of many

29.06.2018 | Elizabeth Pennisi, Science , 2018

Three billion years ago, more or less, life crossed a threshold and began moving toward a multicellular existence. Evidence from multiple directions is showing how this hard-to-fathom leap might have been less difficult than once believed. The evolutionary histories of some groups of organisms ...

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Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

29.06.2018 | Miguel Rodríguez Pulido; María Teresa Sánchez-Aparicio; Encarnación Martínez-Salas; Adolfo García-Sastre; Francisco ..., PLoS Pathogens, 2018

by Miguel Rodríguez Pulido, María Teresa Sánchez-Aparicio, Encarnación Martínez-Salas, Adolfo García-Sastre, Francisco Sobrino, Margarita Sáiz The RNA helicase LGP2 (Laboratory of Genetics and Physiology 2) is a non-signaling member of the retinoic acid-inducible gene-I (RIG-I)-like receptors ...

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A site for sore eyes

29.06.2018 | Caroline Ash; Jesse Smith; Seth Thomas Scanlon, Science , 2018

Immunology![Figure][1] Damage to one eye causes harmful responses in the uninjured eye. PHOTO: JENA ARDELL Mucosal tolerance arises when exposure to foreign antigens at mucosal sites results in suppressed immune responses mediated by regulatory T cells and tolerogenic antigen-presenting

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