01.07.2018 | Jessica S. Kurata; Ren-Jang Lin, RNA, 2018

MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a ...

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30.06.2018 | Ponnusamy Sukumar; Samikannu Ravi, International Journal of Bio-Inspired Computation, 2018

Computer aided detection and classification of Pap smear cell images using principal component analysisPonnusamy Sukumar; Samikannu RaviInternational Journal of Bio-Inspired Computation, Vol. 11, No. 4 (2018) pp. 257 - 266Pap smear is a screening methodology employed in cervix cancer detection ...

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30.06.2018 | Menotti, Laura ; Avitabile, Elisa ; Gatta, Valentina ; Malatesta, Paolo ; Petrovic, Biljana ; Campadelli-Fiume, Gabr ..., Viruses, 2018

Viruses, Vol. 10, Pages 352: HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses Viruses doi: 10.3390/v10070352 Authors: Laura Menotti Elisa Avitabile Valentina Gatta Paolo Malatesta Biljana Petrovic Gabriella ...

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29.06.2018 | Wei Wang; Wilson Wen Bin Goh, International Journal of Bioinformatics Research and Applications, 2018

Sample-to-sample p-value variability and its implications for multivariate analysisWei Wang; Wilson Wen Bin GohInternational Journal of Bioinformatics Research and Applications, Vol. 14, No. 3 (2018) pp. 235 - 254Statistical feature selection is used for identification of relevant genes from ...

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29.06.2018 | Monika Lesicka; Ewa Jabłońska; Edyta Wieczorek; Barbara Seroczyńska; Anna Siekierzycka; Jarosław Skokowski; Leszek K ..., PLoS ONE, 2018

by Monika Lesicka, Ewa Jabłońska, Edyta Wieczorek, Barbara Seroczyńska, Anna Siekierzycka, Jarosław Skokowski, Leszek Kalinowski, Wojciech Wąsowicz, Edyta Reszka Breast cancer has a multifactorial etiology. One of the supposed and novel mechanisms is an alteration of circadian gene expression. ...

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29.06.2018 | Ken Garber, Science , 2018

Some cancers generate the seeds of their own destruction. Ten years ago, researchers discovered that certain random mutations that accumulate in rapidly dividing tumor cells can spur the immune system to attack the cancer. Lately, researchers have found that the extent of such mutations can ...

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29.06.2018 | Francesca Buontempo; Ester Orsini; Isabella Zironi; Lorenzo Isolan; Alessandra Cappellini; Stefania Rapino; Agostino ..., PLoS ONE, 2018

by Francesca Buontempo, Ester Orsini, Isabella Zironi, Lorenzo Isolan, Alessandra Cappellini, Stefania Rapino, Agostino Tartari, Domiziano Mostacci, Giorgio Cucchi, Alberto Maria Martelli, Marco Sumini, Gastone Castellani Radiation therapy is a useful and standard tumor treatment strategy. ...

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29.06.2018 | Nick Henscheid; Eric Clarkson; Kyle J. Myers; Harrison H. Barrett, PLoS ONE, 2018

by Nick Henscheid, Eric Clarkson, Kyle J. Myers, Harrison H. Barrett Many different physiological processes affect the growth of malignant lesions and their response to therapy. Each of these processes is spatially and genetically heterogeneous; dynamically evolving in time; controlled by many ...

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29.06.2018 | Elizabeth Pennisi, Science , 2018

A decade ago, a radical theory of cancer emerged: that this plague of multicellular organisms arises when multicellularity breaks down, and cells start acting as if they were on their own. Recently computational cancer biologists examined gene expression in seven types of solid cancers and traced ...

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29.06.2018 | Nagarajan Kannan; Connie J. Eaves, Science , 2018

The adult mammary gland is a bilayered branching epithelial structure consisting of an outer layer of basal cells and an inner layer of luminal cells. The neonatal structure expands rapidly during puberty and then undergoes cyclic growth in response to the changing hormonal stimuli (progesterone ...

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