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765 Aktuelle Fachpublikationen zum Thema Asthma

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Finding a role for PNECs in asthma

08.06.2018 | Stella Hurtley; Seth Thomas Scanlon, Science , 2018

Immunology Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a

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Pulmonary neuroendocrine cells amplify allergic asthma responses

08.06.2018 | Pengfei Sui; Darin L. Wiesner; Jinhao Xu; Yan Zhang; Jinwoo Lee; Steven Van Dyken; Amber Lashua; Chuyue Yu; Bruce S. ..., Science , 2018

Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a critical ...

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A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

21.05.2018 | Zhaozhong Zhu; Phil H. Lee; Mark D. Chaffin; Wonil Chung; Po-Ru Loh; Quan Lu; David C. Christiani; Liming Liang, Nature Genetics, 2018

Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available ...

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Maternal asthma is associated with increased risk of perinatal mortality

18.05.2018 | Mari Kemppainen; Anna-Maria Lahesmaa-Korpinen; Paula Kauppi; Martti Virtanen; Suvi M. Virtanen; Riitta Karikoski; Mi ..., PLoS ONE, 2018

by Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M. Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen Background Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. Objectives Our goal was ...

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Targeting cytokines to treat asthma and chronic obstructive pulmonary disease

06.04.2018 | Peter J. Barnes, Nature Reviews Immunology, 2018

Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation in asthma and chronic obstructive pulmonary disease (COPD), making them attractive targets for treating these disorders. Asthma and some cases of COPD are mainly driven by type 2 immune responses, which ...

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Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys

21.03.2018 | Author(s): Chintam Nagendra Reddy, Hussam Alhamza, Shishir Chourey, Qiuji Ye, Vivek Gore, Chantal Cosset ..., European Journal of Pharmaceutical Science, 2018

Publication date: 30 March 2018 Source:European Journal of Pharmaceutical Sciences, Volume 115 Author(s): Chintam Nagendra Reddy, Hussam Alhamza, Shishir Chourey, Qiuji Ye, Vivek Gore, Chantal Cossette, Sylvie Gravel, Irina Slobodchikova, Dajana Vuckovic, Joshua Rokach, ...

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IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

21.03.2018 | Tomasz Herjan; Lingzi Hong; Jodi Bubenik; Katarzyna Bulek; Wen Qian; Caini Liu; Xiao Li; Xing Chen; Hui Yang; Suidon ..., Nature Immunology, 2018

Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop ...

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Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms

18.03.2018 | Asher Haug-Baltzell; Tushar R. Bhangale; Diana Chang; Amy Dressen; Brian L. Yaspan; Ward Ortmann; Matthew J. Brauer; ..., Genes and Immunity, 2018

In clinical trials, a placebo response refers to improvement in disease symptoms arising from the psychological effect of receiving a treatment rather than the actual treatment under investigation. Previous research has reported genomic variation associated with the likelihood of observing a ...

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Asthma: Alternative route to airway relaxation

16.03.2018 | Sarah Crunkhorn, Nature Reviews Drug Discovery, 2018

Asthma: Alternative route to airway relaxation Asthma: Alternative route to airway relaxation, Published online: 16 March 2018; doi:10.1038/nrd.2018.37 Asthma: Alternative route to airway relaxation

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Asthma: Alternative route to airway relaxation

16.03.2018 | Sarah Crunkhorn, Nature Reviews Drug Discovery, 2018

Asthma: Alternative route to airway relaxation Asthma: Alternative route to airway relaxation, Published online: 16 March 2018; doi:10.1038/nrd.2018.37 Asthma: Alternative route to airway relaxation

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