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The importance of using public data to validate reported associations

29.06.2018 | Georgia Chenevix-Trench; Jonathan Beesley; Paul D. P. Pharoah; Andrew Berchuck, PLoS Genetics, 2018

by Georgia Chenevix-Trench, Jonathan Beesley, Paul D. P. Pharoah, Andrew Berchuck


Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species

29.06.2018 | Guohong Zeng; Peng Zhang; Qiangqiang Zhang; Hong Zhao; Zixin Li; Xing Zhang; Chengshu Wang; Wen-Bing Yin; Weiguo Fang, PLoS Genetics, 2018

by Guohong Zeng, Peng Zhang, Qiangqiang Zhang, Hong Zhao, Zixin Li, Xing Zhang, Chengshu Wang, Wen-Bing Yin, Weiguo Fang The ecological importance of the duplication and diversification of gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we ...


Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

28.06.2018 | Kristof Theys; Alison F. Feder; Maoz Gelbart; Marion Hartl; Adi Stern; Pleuni S. Pennings, PLoS Genetics, 2018

by Kristof Theys, Alison F. Feder, Maoz Gelbart, Marion Hartl, Adi Stern, Pleuni S. Pennings HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the ...


Inositol polyphosphates regulate and predict yeast pseudohyphal growth phenotypes

25.06.2018 | Kaitlyn L. Norman; Christian A. Shively; Amberlene J. De La Rocha; Nebibe Mutlu; Sukanya Basu; Paul J. Cullen; Anuj ..., PLoS Genetics, 2018

by Kaitlyn L. Norman, Christian A. Shively, Amberlene J. De La Rocha, Nebibe Mutlu, Sukanya Basu, Paul J. Cullen, Anuj Kumar Pseudohyphal growth is a nutrient-regulated program in which budding yeast form multicellular filaments of elongated and connected cells. Filamentous growth is required ...


OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses

25.06.2018 | Sayaka Hori; Shigekazu Oda; Yuji Suehiro; Yuichi Iino; Shohei Mitani, PLoS Genetics, 2018

by Sayaka Hori, Shigekazu Oda, Yuji Suehiro, Yuichi Iino, Shohei Mitani Optimization of the types and timing of avoidance behaviors depending on the intensity of a noxious stimulus is essential for survival; however, processing in the central nervous system and its developmental basis are ...


CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis

22.06.2018 | Xènia Crespo-Yàñez; Carmen Aguilar-Gurrieri; Anne-Claire Jacomin; Agnès Journet; Magda Mortier; Emmanuel Taillebourg ..., PLoS Genetics, 2018

by Xènia Crespo-Yàñez, Carmen Aguilar-Gurrieri, Anne-Claire Jacomin, Agnès Journet, Magda Mortier, Emmanuel Taillebourg, Emmanuelle Soleilhac, Winfried Weissenhorn, Marie-Odile Fauvarque Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptors ...


The long and short of lifespan regulation by Argonautes

21.06.2018 | Kristen C. Brown; Taiowa A. Montgomery, PLoS Genetics, 2018

by Kristen C. Brown, Taiowa A. Montgomery


Craniofacial genetics: Where have we been and where are we going?

21.06.2018 | Seth M. Weinberg; Robert Cornell; Elizabeth J. Leslie, PLoS Genetics, 2018

by Seth M. Weinberg, Robert Cornell, Elizabeth J. Leslie


Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging

21.06.2018 | Antti P. Aalto; Ian A. Nicastro; James P. Broughton; Laura B. Chipman; William P. Schreiner; Jerry S. Chen; Amy E. P ..., PLoS Genetics, 2018

by Antti P. Aalto, Ian A. Nicastro, James P. Broughton, Laura B. Chipman, William P. Schreiner, Jerry S. Chen, Amy E. Pasquinelli Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis ...


A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa

20.06.2018 | Lalanthi Ratnayake; Keyur K. Adhvaryu; Elizabeth Kafes; Kamyar Motavaze; Patricia Lakin-Thomas, PLoS Genetics, 2018

by Lalanthi Ratnayake, Keyur K. Adhvaryu, Elizabeth Kafes, Kamyar Motavaze, Patricia Lakin-Thomas The TOR (Target of Rapamycin) pathway is a highly-conserved signaling pathway in eukaryotes that regulates cellular growth and stress responses. The cellular response to amino acids or carbon ...


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