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3.712 Aktuelle Fachpublikationen in PLoS Computational Biology

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Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes

29.06.2018 | Gregory J. Gerling; Lingtian Wan; Benjamin U. Hoffman; Yuxiang Wang; Ellen A. Lumpkin, PLoS Computational Biology, 2018

by Gregory J. Gerling, Lingtian Wan, Benjamin U. Hoffman, Yuxiang Wang, Ellen A. Lumpkin Distinct firing properties among touch receptors are influenced by multiple, interworking anatomical structures. Our understanding of the functions and crosstalk of Merkel cells and their associated ...

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Two critical positions in zinc finger domains are heavily mutated in three human cancer types

28.06.2018 | Daniel Munro; Dario Ghersi; Mona Singh, PLoS Computational Biology, 2018

by Daniel Munro, Dario Ghersi, Mona Singh A major goal of cancer genomics is to identify somatic mutations that play a role in tumor initiation or progression. Somatic mutations within transcription factors are of particular interest, as gene expression dysregulation is widespread in cancers. ...

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Thalamocortical and intracortical laminar connectivity determines sleep spindle properties

27.06.2018 | Giri P. Krishnan; Burke Q. Rosen; Jen-Yung Chen; Lyle Muller; Terrence J. Sejnowski; Sydney S. Cash; Eric Halgren; M ..., PLoS Computational Biology, 2018

by Giri P. Krishnan, Burke Q. Rosen, Jen-Yung Chen, Lyle Muller, Terrence J. Sejnowski, Sydney S. Cash, Eric Halgren, Maxim Bazhenov Sleep spindles are brief oscillatory events during non-rapid eye movement (NREM) sleep. Spindle density and synchronization properties are different in MEG versus ...

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Age density patterns in patients medical conditions: A clustering approach

26.06.2018 | Fahad Alhasoun; Faisal Aleissa; May Alhazzani; Luis G. Moyano; Claudio Pinhanez; Marta C. González, PLoS Computational Biology, 2018

by Fahad Alhasoun, Faisal Aleissa, May Alhazzani, Luis G. Moyano, Claudio Pinhanez, Marta C. González This paper presents a data analysis framework to uncover relationships between health conditions, age and sex for a large population of patients. We study a massive heterogeneous sample of 1.7 ...

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Correction: A Mixture of Delta-Rules Approximation to Bayesian Inference in Change-Point Problems

26.06.2018 | Robert C. Wilson; Matthew R. Nassar; Gaia Tavoni; Joshua I. Gold, PLoS Computational Biology, 2018

by Robert C. Wilson, Matthew R. Nassar, Gaia Tavoni, Joshua I. Gold

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Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database

25.06.2018 | Luke Zappia; Belinda Phipson; Alicia Oshlack, PLoS Computational Biology, 2018

by Luke Zappia, Belinda Phipson, Alicia Oshlack As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the number of tools designed to analyse these data has dramatically increased. Navigating the vast sea of tools now available is becoming increasingly challenging for ...

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Removing contaminants from databases of draft genomes

25.06.2018 | Jennifer Lu; Steven L. Salzberg, PLoS Computational Biology, 2018

by Jennifer Lu, Steven L. Salzberg Metagenomic sequencing of patient samples is a very promising method for the diagnosis of human infections. Sequencing has the ability to capture all the DNA or RNA from pathogenic organisms in a human sample. However, complete and accurate characterization of ...

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The impact of temporal sampling resolution on parameter inference for biological transport models

25.06.2018 | Jonathan U. Harrison; Ruth E. Baker, PLoS Computational Biology, 2018

by Jonathan U. Harrison, Ruth E. Baker Imaging data has become an essential tool to explore key biological questions at various scales, for example the motile behaviour of bacteria or the transport of mRNA, and it has the potential to transform our understanding of important transport ...

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Transmission of temporally correlated spike trains through synapses with short-term depression

22.06.2018 | Alex D. Bird; Magnus J. E. Richardson, PLoS Computational Biology, 2018

by Alex D. Bird, Magnus J. E. Richardson Short-term synaptic depression, caused by depletion of releasable neurotransmitter, modulates the strength of neuronal connections in a history-dependent manner. Quantifying the statistics of synaptic transmission requires stochastic models that link ...

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Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach

22.06.2018 | Nicolas Henry; Eva-Maria Krammer; Florian Stengel; Quentin Adams; François Van Liefferinge; Ellen Hubin; Rui Chaves; ..., PLoS Computational Biology, 2018

by Nicolas Henry, Eva-Maria Krammer, Florian Stengel, Quentin Adams, François Van Liefferinge, Ellen Hubin, Rui Chaves, Rouslan Efremov, Ruedi Aebersold, Guy Vandenbussche, Martine Prévost, Vincent Raussens, Stéphanie Deroo Apolipoprotein E (apoE) is a forefront actor in the transport of lipids ...

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