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7.976 Aktuelle Fachpublikationen in Nucleic Acids Research


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Regenerating livers of old rats contain high levels of C/EBPα that correlate with altered expression of cell cycle associated proteins

01.07.1998 | Nikolai A. Timchenko; Margaret Wilde; Ken-Ichiro Kosai; Ahmed Heydari; Timothy A. Bilyeu; Milton J. Finegold; Khalid ..., Nucleic Acids Research, 1998

Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). An essential part of TER is the template/pseudoknot domain (t/PK) which includes the template, for adding telomeric repeats, template boundary ...


Computational approaches to identify leucine zippers

01.06.1998 | Erich Bornberg-Bauer; Eric Rivals; Martin Vingron, Nucleic Acids Research, 1998

ChEMBL is an open large-scale bioactivity database (, previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, alongside the continued extraction of data from the medicinal chemistry literature, new sources of bioactivity data have ...


Quantification of Bcr-Abl Transcripts in Chronic Myelogenous Leukemia (CML) Using Standardized, Internally Controlled, Competitive Differential PCR (CD-PCR)

01.10.1996 | Stefan Nagel; Manuel Schmidt; Christian Thiede; Dieter Huhn; Andreas Neubauer, Nucleic Acids Research, 1996

SZGR 2.0 is a comprehensive resource of candidate variants and genes for schizophrenia, covering genetic, epigenetic, transcriptomic, translational and many other types of evidence. By systematic review and curation of multiple lines of evidence, we included almost all variants and genes that ...


An mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A

11.10.1995 | M. Ahmad Chaudhry; Michael Weinfeld, Nucleic Acids Research, 1995

c-Src, a non-receptor protein tyrosine kinase, activates NF-B and STAT3, which in turn triggers the transcription of anti-apoptosis- and cell cycle-related genes. c-Src protein regulates cell proliferation, cell motility and programmed cell death. And the elevated level of activated c-Src protein ...


Nucleotide sequence of katF of Escherichia coli suggests KatF protein is a novel σ transcription factor

11.12.1989 | Michael R. Mulvey; Peter C. Loewen, Nucleic Acids Research, 1989

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics ...


Structural requirements of polynucleotides for the activation of (2′-5′)An polymerase and protein kinase

10.10.1981 | Corrado Baglioni; Michael A. Minks; Erik De Clercq, Nucleic Acids Research, 1981

The small nuclear RNA (snRNA) components of the spliceosome undergo many conformational rearrangements during its assembly, catalytic activation and disassembly. The U4 and U6 snRNAs are incorporated into the spliceosome as a base-paired complex within the U4/U6.U5 small nuclear ribonucleoprotein ...


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