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7.976 Aktuelle Fachpublikationen in Nucleic Acids Research

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Emerin modulates spatial organization of chromosome territories in cells on softer matrices

19.04.2018 | Pradhan R, Ranade D, Sengupta K., Nucleic Acids Research, 2018

Abstract Cells perceive and relay external mechanical forces into the nucleus through the nuclear envelope. Here we examined the effect of lowering substrate stiffness as a paradigm to address the impact of altered mechanical forces on nuclear structure-function relationships. RNA sequencing of ...

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A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer

18.04.2018 | Dumbović G, Biayna J, Banús J, et al., Nucleic Acids Research, 2018

Abstract Primate-specific NBL2 macrosatellite is hypomethylated in several types of tumors, yet the consequences of this DNA hypomethylation remain unknown. We show that NBL2 conserved repeats are close to the centromeres of most acrocentric chromosomes. NBL2 associates with the perinucleolar ...

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Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations

17.04.2018 | Sharma A, Jiang C, De S., Nucleic Acids Research, 2018

Abstract Although the catalog of cancer-associated mutations in protein-coding regions is nearly complete for all major cancer types, an assessment of regulatory changes in cancer genomes and their clinical significance remain largely preliminary. Adopting bottom-up approach, we quantify the ...

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The nonstop decay and the RNA silencing systems operate cooperatively in plants

17.04.2018 | Szádeczky-Kardoss I, Csorba T, Auber A, et al., Nucleic Acids Research, 2018

Abstract Translation-dependent mRNA quality control systems protect the protein homeostasis of eukaryotic cells by eliminating aberrant transcripts and stimulating the decay of their protein products. Although these systems are intensively studied in animals, little is known about the ...

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Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair

17.04.2018 | Kato-Inui T, Takahashi G, Hsu S, et al., Nucleic Acids Research, 2018

Abstract Genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) predominantly induces non-homologous end joining (NHEJ), which generates random insertions or deletions, whereas homology-directed repair (HDR), which generates ...

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Multiple RPAs make WRN syndrome protein a superhelicase

14.04.2018 | Lee M, Shin S, Uhm H, et al., Nucleic Acids Research, 2018

Abstract RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use single-molecule FRET and magnetic tweezers to investigate the helicase activity of WRN and its stimulation by RPA. We show that WRN alone is a ...

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DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1

14.04.2018 | Wang X, Srivastava Y, Jankowski A, et al., Nucleic Acids Research, 2018

Abstract FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed ‘DIV’ for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive ...

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Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus

12.04.2018 | Miyazono K, Ishino S, Makita N, et al., Nucleic Acids Research, 2018

Abstract Because base deaminations, which are promoted by high temperature, ionizing radiation, aerobic respiration and nitrosative stress, produce mutations during replication, deaminated bases must be repaired quickly to maintain genome integrity. Recently, we identified a novel lesion-specific ...

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Pseudomonas aeruginosa partitioning protein ParB acts as a nucleoid-associated protein binding to multiple copies of a parS-related motif

10.04.2018 | Kawalek A, Bartosik A, Glabski K, et al., Nucleic Acids Research, 2018

Abstract ParA and ParB homologs are involved in accurate chromosome segregation in bacteria. ParBs participate in the separation of ori domains by binding to parS palindromes, mainly localized close to oriC. In Pseudomonas aeruginosa neither ParB deficiency nor modification of all 10 parSs is ...

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Translatome analysis at the egg-to-embryo transition in sea urchin

06.04.2018 | Chassé H, Aubert J, Boulben S, et al., Nucleic Acids Research, 2018

Abstract Early embryogenesis relies on the translational regulation of maternally stored mRNAs. In sea urchin, fertilization triggers a dramatic rise in translation activity, necessary for the onset of cell division. Here, the full spectrum of the mRNAs translated upon fertilization was ...

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