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7.976 Aktuelle Fachpublikationen in Nucleic Acids Research
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16.05.2018 | Lui L, Uzilov A, Bernick D, et al., Nucleic Acids Research, 2018
Abstract Archaeal homologs of eukaryotic C/D box small nucleolar RNAs (C/D box sRNAs) guide precise 2′-O-methyl modification of ribosomal and transfer RNAs. Although C/D box sRNA genes constitute one of the largest RNA gene families in archaeal thermophiles, most genomes have incomplete sRNA gene ...
14.05.2018 | Dutta D, Debnath M, Müller D, et al., Nucleic Acids Research, 2018
Abstract The structural differences among different G-quadruplexes provide an opportunity for site-specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex ligands described thus far show little selectivity among different G-quadruplexes. In this work, we ...
10.05.2018 | Nguyen T, Park J, Dang T, et al., Nucleic Acids Research, 2018
Abstract Microprocessor, which consists of a ribonuclease III DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) maturation by cleaving primary miRNA transcripts (pri-miRNAs). We recently demonstrated that the DGCR8 dimer recognizes the apical elements of pri-miRNAs, including the UGU ...
09.05.2018 | Danaee P, Rouches M, Wiley M, et al., Nucleic Acids Research, 2018
Abstract While RNA secondary structure prediction from sequence data has made remarkable progress, there is a need for improved strategies for annotating the features of RNA secondary structures. Here, we present bpRNA, a novel annotation tool capable of parsing RNA structures, including complex ...
09.05.2018 | Bucca G, Pothi R, Hesketh A, et al., Nucleic Acids Research, 2018
Abstract Stress-induced adaptations require multiple levels of regulation in all organisms to repair cellular damage. In the present study we evaluated the genome-wide transcriptional and translational changes following heat stress exposure in the soil-dwelling model actinomycete bacterium, ...
04.05.2018 | Hewawasam G, Dhatchinamoorthy K, Mattingly M, et al., Nucleic Acids Research, 2018
Nucleic Acids Research, gky169, https://doi.org/10.1093/nar/gky169
30.04.2018 | Rehman I, Basu S, Das S, et al., Nucleic Acids Research, 2018
Abstract Human tyrosyl-DNA phosphodiesterases (TDP) hydrolyze the phosphodiester bond between DNA and the catalytic tyrosine of Top1 to excise topoisomerase I cleavage complexes (Top1cc) that are trapped by camptothecin (CPT) and by genotoxic DNA alterations. Here we show that the protein ...
19.04.2018 | Scott S, Xu Z, Kouzine F, et al., Nucleic Acids Research, 2018
Abstract We directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of DNA supercoiling and temperature. The visualization relies on containing the DNA molecules within ...
19.04.2018 | Dolot R, Lam C, Sierant M, et al., Nucleic Acids Research, 2018
Abstract Thrombin-binding aptamer (TBA) is a DNA 15-mer of sequence 5′-GGT TGG TGT GGT TGG-3′ that folds into a G-quadruplex structure linked by two T-T loops located on one side and a T-G-T loop on the other. These loops are critical for post-SELEX modification to improve TBA target affinity. ...
19.04.2018 | Chiu H, Martínez M, . Komissarova E, et al., Nucleic Acids Research, 2018
Abstract microRNAs (miRNAs) play key roles in cancer, but their propensity to couple their targets as competing endogenous RNAs (ceRNAs) has only recently emerged. Multiple models have studied ceRNA regulation, but these models did not account for the effects of co-regulation by miRNAs with many ...
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