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2.761 Aktuelle Fachpublikationen in Journal of Natural Products


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Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens

19.01.2018 | Yulin Ren; Judith C. Gallucci; Xinxin Li; Lichao Chen; Jianhua Yu; A. Douglas Kinghorn, Journal of Natural Products, 2018

The molecular structures of three parthenolide analogues, (−)-goyazensolide (1), (−)-15-deoxygoyazensolide (2), and (−)-ereglomerulide (3), isolated from the leaves of Piptocoma rufescens in a previous study were determined by X-ray analysis, and the absolute configuration of (−)-goyazensolide ...


Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers

18.01.2018 | Xiaohui Yan; Hindra; Huiming Ge; Dong Yang; Tingting Huang; Ivana Crnovcic; Chin-Yuan Chang; Shi-Ming Fang; Thibault ..., Journal of Natural Products, 2018

The potent cytotoxicity and unique mode of action make the enediyne antitumor antibiotic C-1027 an exquisite drug candidate for anticancer chemotherapy. However, clinical development of C-1027 has been hampered by its low titer from the original producer Streptomyces globisporus C-1027. Here we ...


Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus

17.01.2018 | Morten K. Moe; Tor Haug; Magne O. Sydnes; Sigmund V. Sperstad; Chun Li; Lena C. Vaagsfjord; Enrique de la Vega; Klar ..., Journal of Natural Products, 2018

As part of an ongoing exploration of marine invertebrates as a source of new antimicrobial peptides, hemocyte extracts from the red king crab, Paralithodes camtschaticus, were studied. Three cationic cysteine (Cys)-rich peptides, named paralithocins 1–3, were isolated by bioassay-guided ...


Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074

17.01.2018 | Xiangyang Liu; Dongxu Liu; Min Xu; Meifeng Tao; Linquan Bai; Zixin Deng; Blaine A. Pfeifer; Ming Jiang, Journal of Natural Products, 2018

Diazofluorene compounds such as kinamycin and lomaiviticin feature unique molecular structures and compelling medicinal bioactivities. However, a complete understanding of the biosynthetic details for this family of natural products has yet to be fully elucidated. In addition, a lack of ...


Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum

17.01.2018 | Dan Yang; Zhong-Quan Cheng; Liu Yang; Bo Hou; Jing Yang; Xiao-Nian Li; Cheng-Ting Zi; Fa-Wu Dong; Zheng-Hua Liu; Jun ..., Journal of Natural Products, 2018

Investigation of the 95% EtOH extract of stems of Dendrobium findlayanum afforded four new seco-dendrobines, findlayines A–D (1–4); two known dendrobines, dendrobine (5) and 2-hydroxydendrobine (6); and four new phenolic compounds, dendrofindlaphenols A–C (7, 9, and 10) and ...


Prenylated 2-Phenoxychromones and Flavonoids from Epimedium brevicornum and Revised Structures of Epimedonins A and B

17.01.2018 | Fu-Cai Ren; Xian-Jun Jiang; Shi-Zhen Wen; Li-Xia Wang; Xiang-Mei Li; Fei Wang, Journal of Natural Products, 2018

Six hitherto unknown prenylated 2-phenoxychromones, epimedonin G (1), 7-O-methylepimedonin G (2), and epimedonins H–K (3–6), and two new prenylflavonoids, epimedonin L (7) and 3″-O-desmethylspinorhamnoside (8), were isolated from an ethanol extract of the aerial parts of Epimedium brevicornum. ...


Evaluation of Diarylheptanoid–Terpene Adduct Enantiomers from Alpinia officinarum for Neuroprotective Activities

11.01.2018 | Hui Liu; Zhen-Long Wu; Xiao-Jun Huang; Yinghui Peng; Xiaojie Huang; Lei Shi; Ying Wang; Wen-Cai Ye, Journal of Natural Products, 2018

Two pairs of new diarylheptanoid–monoterpene adduct enantiomers, (±)-alpininoids A and B [(±)-1 and (±)-2], as well as three pairs of new diarylheptanoid–sesquiterpene adduct enantiomers, (±)-alpininoids C–E [(±)-3–(±)-5], together with four known diarylheptanoids (6–9) were isolated from the ...


Computer-Assisted 3D Structure Elucidation (CASE-3D) of Natural Products Combining Isotropic and Anisotropic NMR Parameters

11.01.2018 | Armando Navarro-Vázquez; Roberto R. Gil; Kirill Blinov, Journal of Natural Products, 2018

A computer-assisted structural elucidation (CASE-3D) strategy based on the use of isotropic and/or anisotropic NMR data is proposed to elucidate relative configuration and preferred conformation in complex natural products. The methodology involves the selection of conformational models through ...


Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle

22.12.2017 | Junfei Zhou; Tingting Liu; Hanqi Zhang; Guijuan Zheng; Yue Qiu; Mengyi Deng; Chun Zhang; Guangmin Yao, Journal of Natural Products, 2017

Thirteen new grayanane diterpenoids (1–13), a new dimeric grayanane diterpenoid, bimollfoliagein A (14), and 15 known analogues (15–29) were isolated from the leaves of Rhododendron molle. The structures of the new compounds (1–14) were determined by extensive spectroscopic data interpretation. ...


Rearranged Phloroglucinol-Monoterpenoid Adducts from Callistemon rigidus

20.12.2017 | Jia-Qing Cao; Hai-Yan Tian; Man-Mei Li; Wei Zhang; Ying Wang; Lei Wang; Wen-Cai Ye, Journal of Natural Products, 2017

Callisretones A (1) and B (2), two rearranged phloroglucinol-monoterpenoid adducts featuring an unprecedented isopropylcyclopenta[b]benzofuran backbone, together with their postulated biosynthetic precursors (3–9), were isolated from Callistemon rigidus. The previously assigned absolute ...


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