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3.166 Aktuelle Fachpublikationen in Biomacromolecules


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Cyclam-Modified PEI for Combined VEGF siRNA Silencing and CXCR4 Inhibition To Treat Metastatic Breast Cancer

19.01.2018 | Yiwen Zhou; Fei Yu; Feiran Zhang; Gang Chen; Kaikai Wang; Minjie Sun; Jing Li; David Oupický, Biomacromolecules, 2018

Chemokine receptor CXCR4 plays an important role in cancer cell invasion and metastasis. Recent findings suggest that anti-VEGF therapies upregulate CXCR4 expression, which contributes to resistance to antiangiogenic therapies. Here, we report the development of novel derivatives of ...


Influence of Constraints within a Cyclic Polymer on Solution Properties

18.01.2018 | Md. D. Hossain; James C. Reid; Derong Lu; Zhongfan Jia; Debra J. Searles; Michael J. Monteiro, Biomacromolecules, 2018

Cyclic polymers with internal constraints provide new insight into polymer properties in solution and bulk and can serve as a model system to explain the stability and mobility of cyclic biomacromolecules. The model system used in this work consisted of cyclic polystyrene structures, all with a ...


Cold and Hot Gelling of Alginate-graft-PNIPAM: a Schizophrenic Behavior Induced by Potassium Salts

18.01.2018 | Hui Guo; Mickaël de Magalhaes Goncalves; Guylaine Ducouret; Dominique Hourdet, Biomacromolecules, 2018

Recently, alginates (ALG) characterized by high mannuronic content (M blocks) have been shown to undergo a reversible sol/gel transition during cooling in the presence of potassium salts. Cold gelling takes place at low temperatures, just below 0 °C for a KCl concentration of 0.3 mol/kg, but the ...


Targeted, Stimuli-Responsive Delivery of Plasmid DNA and miRNAs Using a Facile Self-Assembled Supramolecular Nanoparticle System

18.01.2018 | Li-Yen Wong; Bingzhao Xia; Ernst Wolvetang; Justin Cooper-White, Biomacromolecules, 2018

Gene therapy is rapidly regaining traction in terms of research activity and investment across the globe, with clear potential to revolutionize medicine and tissue regeneration. Viral vectors remain the most commonly utilized gene delivery vehicles, due to their high efficiency, however, they are ...


Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Cross-Linked by Schiff’s Base Formation

18.01.2018 | Takuro Hozumi; Tatsuto Kageyama; Seiichi Ohta; Junji Fukuda; Taichi Ito, Biomacromolecules, 2018

We developed an injectable gelatin/hyaluronic acid hydrogel with slow degradability, which consisted of carbohydrazide-modified gelatin (Gel-CDH) and hyaluronic acid monoaldehyde (HA-mCHO). Gel-CDH/HA-mCHO hydrogels were degraded much more slowly in phosphate-buffered saline than the other ...


Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

17.01.2018 | Patrick D. Mathews; Ana C. M. Fernandes Patta; Joao V. Gonçalves; Gabriella dos Santos Gama; Irene Teresinha Santos ..., Biomacromolecules, 2018

Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via ...


Influence of Poly(styrene-co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs

16.01.2018 | Stephen C. L. Hall; Cecilia Tognoloni; Gareth J. Price; Bert Klumperman; Karen J. Edler; Tim R. Dafforn; Thomas Arnold, Biomacromolecules, 2018

Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that wraps around a segment of lipid bilayer, and as such are capable of encapsulating membrane proteins directly from the cell membrane. To date, most studies on these nanodiscs have used poly(styrene-co-maleic ...


Amphiphilic Alginates for Marine Antifouling Applications

16.01.2018 | Victoria Jakobi; Jana Schwarze; John A. Finlay; Kim A. Nolte; Stephan Spöllmann; Hans-Werner Becker; Anthony S. Clar ..., Biomacromolecules, 2018

Amphiphilic polymers are promising candidates for novel fouling-release coatings for marine applications. We grafted amphiphilic alginates with fluorinated side chains to glass and silicon substrates and characterized the obtained films by contact angle goniometry, spectroscopic ellipsometry, ...


Monodisperse Microshell Structured Gelatin Microparticles for Temporary Chemoembolization

16.01.2018 | Bohyun Kim; Sang Woo Han; Song-Ee Choi; DaBin Yim; Jong-Ho Kim; Hans M. Wyss; Jin Woong Kim, Biomacromolecules, 2018

Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. ...


Acid-Free Preparation of Cellulose Nanocrystals by TEMPO Oxidation and Subsequent Cavitation

16.01.2018 | Yaxin Zhou; Tsuguyuki Saito; Lennart Bergström; Akira Isogai, Biomacromolecules, 2018

Softwood bleached kraft pulp (SBKP) and microcrystalline cellulose (MCC) were oxidized using a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated system. The TEMPO-oxidized SBKP prepared with 10 mmol/g NaClO (SBKP-10) had a higher mass recovery ratio and higher carboxylate content than the ...


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