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Issue Information

22.01.2018 | British Journal of Clinical Pharmacology, 2018

No abstract is available for this article.


Standardisation of inactivated influenza vaccines – learning from history

21.01.2018 | John M Wood, Jerry P Weir, Influenza and Other Respiratory Viruses, 2018

Abstract The single radial immunodiffusion assay has been the accepted method for determining the potency of inactivated influenza vaccines since 1978. The world‐wide adoption of this assay for vaccine standardisation was facilitated through collaborative studies that demonstrated a high level ...


1918 pandemic morbidity: the first wave hits the poor, the second wave hits the rich

21.01.2018 | Svenn‐Erik Mamelund, Influenza and Other Respiratory Viruses, 2018

Abstract Background Whether morbidity from the 1918‐19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was “socially neutral”. Objectives To ...


The unfolding landscape of the congenital myasthenic syndromes

21.01.2018 | Andrew G. Engel, Xin‐Ming Shen, Duygu Selcen, Annals of the New York Academy of Sciences, 2018

Abstract Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes has ...


Passive transfer models of myasthenia gravis with muscle‐specific kinase antibodies

21.01.2018 | Jan J.G.M. Verschuuren, Jaap J. Plomp, Steve J. Burden, Wei Zhang, Yvonne E. Fillié‐Grijpma, Inge E. Stienstra‐van E ..., Annals of the New York Academy of Sciences, 2018

Abstract Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulder and respiratory weakness are more prominent than in acetylcholine receptor (AChR) MG. MuSK ...


Acetylcholine receptor antibody–mediated animal models of myasthenia gravis and the role of complement

21.01.2018 | Linda L. Kusner, Manjistha Sengupta, Henry J. Kaminski, Annals of the New York Academy of Sciences, 2018

Abstract Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for ...


Survey of diagnostic and treatment practices for multiple sclerosis in Europe, part 2: progressive MS, paediatric MS, pregnancy and general management

21.01.2018 | Oscar Fernández, Mario Delvecchio, Gilles Edan, Sten Fredrikson, Gavin Giovannoni, Hans‐Peter Hartung, Eva Havrdova, ..., European Journal of Neurology, 2018

Abstract Background and purpose The European Charcot Foundation supported development of a set of surveys to understand current practice patterns for diagnosis and management of multiple sclerosis (MS) in Europe. Part 2 of the report summarises survey results related to secondary progressive ...


Unknown‐Onset Strokes with Anterior Circulation Occlusion treated by Thrombectomy after DWI‐FLAIR Mismatch Selection

21.01.2018 | Simon Escalard, Benjamin Gory, Maéva Kyheng, Jean‐Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajd ..., European Journal of Neurology, 2018

Abstract Background and purpose The DAWN Trial recently showed compelling evidence in treating late window and wake‐up stroke patients with thrombectomy using a clinical‐imaging mismatch. We aimed to evaluate the results of thrombectomy for unknown‐onset strokes (UOS) treated in our centers ...


A multi‐parent advanced generation inter‐cross (MAGIC) population for genetic analysis and improvement of cowpea (Vigna unguiculata L. Walp.)

21.01.2018 | Bao‐Lam Huynh, Jeffrey D. Ehlers, Bevan Emma Huang, Maria Munoz‐Amatriain, Stefano Lonardi, Jansen R. P. Santos, Ars ..., The Plant Journal, 2018

Summary Multi‐parent Advanced Generation Inter‐Cross (MAGIC) populations are an emerging type of resource to dissect the genetic structure of traits and improve breeding populations. We developed a MAGIC population for cowpea (Vigna unguiculata L. Walp.) from eight founder parents which are ...


Defective XRN3‐mediated transcription termination in Arabidopsis impacts expression of protein‐coding genes

21.01.2018 | Michal Krzyszton, Monika Zakrzewska‐Placzek, Aleksandra Kwasnik, Norbert Dojer, Wojciech Karlowski, Joanna Kufel, The Plant Journal, 2018

Summary Arabidopsis thaliana contains two nuclear XRN2/3 5′‐3′ exonucleases that are homologs of yeast and human Rat1/Xrn2 proteins involved in processing and degradation of several classes of nuclear RNAs and in transcription termination of RNA polymerase II. Using a strand‐specific short ...


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