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MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24

07.11.2017 | Lei Wang; Wan-qing Wei; Zi-yu Wu; Gong-cheng Wang, Molecular BioSystems, 2017

Renal cell carcinoma (RCC) is the leading cause of death in renal malignancies. MicroRNA-590-5p (miR-590-5p) is of great importance in the processes of many cancers regarding regulation of cancer cell invasion and proliferation. In our study, alternation of miR-590-5p expression in RCC cell lines ...


A computational method using differential gene expression to predict altered metabolism of multicellular organisms

07.11.2017 | Lvxing Zhu; Haoran Zheng; Xinying Hu; Yang Xu, Molecular BioSystems, 2017

Altered metabolism is often identified as a cause or an effect of physiology and pathogenesis. But it is difficult to predict the metabolic flux distributions of multicellular organisms due to the lack of an explicit metabolic objective function. Here we present a computational method which can ...


Computational study on the origin of the cancer immunotherapeutic potential of B and T cell epitope peptides

13.09.2017 | Hao Li; Nalini Schaduangrat; Saw Simeon; Chanin Nantasenamat, Molecular BioSystems, 2017

Immune therapy is generally seen as the future of cancer treatment. The discovery of tumor-associated antigens and cytotoxic T lymphocyte epitope peptides spurned intensive research into effective peptide-based cancer vaccines. One of the major obstacles hindering the development of peptide-based ...


A novel method for identifying potential disease-related miRNAs via disease-miRNA-target heterogeneous network

13.09.2017 | Liang Ding; Minghui Wang; Dongdong Sun; Ao Li, Molecular BioSystems, 2017

MicroRNAs (miRNAs), as a kind of important small endogenous single-stranded non-coding RNAs, play critical roles in a large number of human diseases. However, the currently known experimental verification of the disease-miRNA associations are still rare and experimental identification is ...


Investigation of a common gene expression signature in gastrointestinal cancers using systems biology approaches

13.09.2017 | Kaveh Baghaei; Nazanin Hosseinkhan; Hamid Asadzadeh Aghdaei; M. R. Zali, Molecular BioSystems, 2017

According to GLOBOCAN 2012, the incidence and the mortality rate of colorectal, stomach and liver cancers are the highest among the total gastrointestinal (GI) cancers. Here we aimed to find the common genes and pathways that are simultaneously deregulated in these three malignancies using ...


Correction: An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by combined machine learning and molecular pathway analysis

13.09.2017 | Taiyi Wang; Ming Lu; Qunqun Du; Xi Yao; Peng Zhang; Xiaonan Chen; Weiwei Xie; Zheng Li; Yuling Ma; Yan Zhu, Molecular BioSystems, 2017

Correction for ‘An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis’ by Taiyi Wang et al., Mol. BioSyst., 2017, 13, 1018–1030.


Real-time activity assays of [small beta]-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains

13.09.2017 | Ying Ge; Yajun Zhou; Ke-Wu Yang; Yilin Zhang; Yang Xiang; Yuejuan Zhang, Molecular BioSystems, 2017

The emergence of antibiotic resistance caused by β-lactamases, including serine β-lactamases (SβLs) and metallo-β-lactamases (MβLs), is a global public health threat. L1, a B3 subclass MβL, hydrolyzes almost all of known β-lactam antibiotics. We report a simple and straightforward UV-Vis approach ...


Hedgehog-mesenchyme gene signature identifies bi-modal prognosis in Luminal and Basal breast cancer sub-types

13.09.2017 | Wandaliz Torres-Garcia; Maribella Domenech, Molecular BioSystems, 2017

Hedgehog signaling (Hh) has been shown to be hyper-activated in several cancers. However, active Hh signaling can promote or inhibit tumor growth, thus identification of markers beyond main canonical Hh target genes are needed to improve patient selection and clinical outcome in response to Hh ...


Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis

13.09.2017 | Arati Deshmukh; Shakuntala Bai; T Aarthy; Rubina S Kazi; Reema Banarjee; Rajeshwari Rathore; MV Vijayakumar; Hirekod ..., Molecular BioSystems, 2017

Methylglyoxal (MG) is a highly reactive dicarbonyl, known to be elevated in hyperglycemic condition of diabetes and is implicated in development of diabetic complications. Therefore, the current study investigates the role of MG in exacerbating insulin resistance at insulin signaling level, as ...


CarSite: identify carbonylated sites of human proteins based on a one-sided selection resampling method

05.09.2017 | Yun Zuo; Cangzhi Jia, Molecular BioSystems, 2017

Protein carbonylation is one of the most important biomarkers of oxidative protein damage and such protein damage is linked to various diseases and aging. Therefore, it is vital that carbonylation sites are identified accurately. In this study, CarSite, a novel bioinformatics tool, was built to ...


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