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FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII)

18.06.2018 | Bellesso S, Salvalaio M, Lualdi S, et al., Human Molecular Genetics, 2018

Human Molecular Genetics, 2018, 27(13), 2262–2275.


Isolation, identification and characterization of enzyme-producing lactic acid bacteria from traditional fermented foods

15.06.2018 | Ho J, Yin Sze L., Bioscience Horizons, 2018

Abstract Industrialization processes are prone to produce various forms of waste which can be utilized to produce silage. These wastes can be treated by using lactic acid bacteria (LAB), which are known to be potential enzyme producers. Seven strains of LAB were isolated from traditional ...


In silico prediction of protein–protein interaction between Glossina m. morsitans (Westwood, 1851) and Trypanosoma brucei (Kinetoplastida: Trypanosomatidae)

15.06.2018 | Muriithi E, Kinyua J, Nyanjom S., Bioscience Horizons, 2018

Abstract Trypanosoma brucei is a pathogenic protozoa that causes chronic Human African Trypanosomiasis and African Animal Trypanosomiasis. The pathogenic parasite is transmitted to humans by the tsetse fly, Glossina m. morsitans. Trypanosomiasis control strategies have targeted either the tsetse ...


Erratum to “N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems” and “High-Affinity Low-Capacity and Low-Affinity High-Capacity N-Acetyl-2-Aminofluorene (AAF) Macromolecular Binding Sites Are Revealed During the Growth Cycle of Adult Rat Hepatocytes in Primary Culture”

25.05.2018 | Koch K, Moran T, Shier W, et al., Toxicological Sciences, 2018

The above mentioned articles were inadvertently switched in the May 2018 issue of Toxicological Sciences (Volume 163, Number 1). The pagination details have now been corrected in the final versions of these articles (; ...


MEGA Software Celebrates Silver Anniversary

16.05.2018 | Caspermeyer J., Molecular Biology and Evolution, 2018

In the past 25 years, stretching from the dawn of personal computing to the social media age, the “always free” molecular evolutionary genetics analysis (MEGA) tool has been downloaded 1.6 million times worldwide.


Methylation guide RNA evolution in archaea: structure, function and genomic organization of 110 C/D box sRNA families across six Pyrobaculum species

16.05.2018 | Lui L, Uzilov A, Bernick D, et al., Nucleic Acids Research, 2018

Abstract Archaeal homologs of eukaryotic C/D box small nucleolar RNAs (C/D box sRNAs) guide precise 2′-O-methyl modification of ribosomal and transfer RNAs. Although C/D box sRNA genes constitute one of the largest RNA gene families in archaeal thermophiles, most genomes have incomplete sRNA gene ...


Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice

15.05.2018 | Usui Y, Kimura Y, Satoh T, et al., International Immunology, 2018

Abstract The gut is an extremely complicated ecosystem where micro-organisms, nutrients and host cells interact vigorously. Although the function of the intestine and its barrier system weakens with age, some probiotics can potentially prevent age-related intestinal dysfunction. Lactobacillus ...


Neutral Theory and the Somatic Evolution of Cancer

14.05.2018 | Molecular Biology and Evolution, 2018

Vincent L. Cannataro and Jeffrey P. Townsend


Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

14.05.2018 | Dutta D, Debnath M, Müller D, et al., Nucleic Acids Research, 2018

Abstract The structural differences among different G-quadruplexes provide an opportunity for site-specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex ligands described thus far show little selectivity among different G-quadruplexes. In this work, we ...


Microprocessor depends on hemin to recognize the apical loop of primary microRNA

10.05.2018 | Nguyen T, Park J, Dang T, et al., Nucleic Acids Research, 2018

Abstract Microprocessor, which consists of a ribonuclease III DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) maturation by cleaving primary miRNA transcripts (pri-miRNAs). We recently demonstrated that the DGCR8 dimer recognizes the apical elements of pri-miRNAs, including the UGU ...


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