01.10.2011 | Su, E. W., Bi, S., Kane, L. P., Glycobiology , 2011

β-Galactoside-binding lectin 9 (galectin-9) is a tandem repeat-type member of the galectin family. It was initially characterized as an eosinophil chemoattractant and an inducer of apoptosis in thymocytes. Subsequently, galectin-9 was identified as a ligand for transmembrane immunoglobulin mucin ...

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01.10.2011 | Young, N. M., Kreisman, L. S., Stupak, J., MacLean, L. L., Cobb, B. A., Richards, J. C., Glycobiology , 2011

Morganella morganii is a commensal Gram-negative bacterium that has long been known to produce an antigen bearing phosphocholine groups. We determined the structure of this O-chain antigen and found that its repeating unit also contains a free amino group and a second phosphate: This ...

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01.10.2011 | Henderson, G., Ulsemer, P., Schober, U., Loffler, A., Alpert, C.-A., Zimmermann-Kordmann, M., Reutter, W., Karsten, ..., Glycobiology , 2011

The Thomsen–Friedenreich antigen (TF; CD176, Galβ1-3GalNAcα-) is a tumor-specific carbohydrate antigen and a promising therapeutic target. Antibodies that react with this antigen are frequently found in the sera of healthy adults and are assumed to play a role in cancer immunosurveillance. In ...

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01.10.2011 | Zandberg, W. F., Benjannet, S., Hamelin, J., Pinto, B. M., Seidah, N. G., Glycobiology , 2011

The limited proteolysis of proteins by the proprotein convertases (PCs) is a common means of producing bioactive proteins or peptides. The PCs are associated with numerous human pathologies and their activity can be reduced through the use of specific inhibitors. Here, we demonstrate an ...

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01.10.2011 | Kozma, E. M., Wisowski, G., Kusz, D., Olczyk, K., Glycobiology , 2011

Organ fibrosis is associated with excessive deposition of dermatan sulfate (DS) in the extracellular matrix (ECM) of the affected tissue. However, the significance of DS in fibrosis process is poorly known. Thus, we have analyzed both in vitro and in vivo the binding potential toward fibroblast ...

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01.10.2011 | Marino, K., Lane, J. A., Abrahams, J. L., Struwe, W. B., Harvey, D. J., Marotta, M., Hickey, R. M., Rudd, P. M., Glycobiology , 2011

Although the properties of milk oligosaccharides have been of scientific interest for many years, their structural diversity presents a challenging analytical task. In the quest for a simple and robust technology to characterize the different oligosaccharides present in milk, we developed an ...

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01.10.2011 | Otto, Nigel J; Solakyildirim, Kemal; Linhardt, Robert J; DeAngelis, Paul L, Glycobiology , 2011

Glycosaminoglycans (GAGs) are linear hexosamine-containing polysaccharides. These polysaccharides are synthesized by some pathogenic bacteria to form an extracellular coating or capsule. This strategy forms the basis of molecular camouflage since vertebrates possess naturally occurring GAGs that ...

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01.10.2011 | Hirayama, H., Suzuki, T., Glycobiology , 2011

In eukaryotic cells, it is known that N-glycans play a pivotal role in quality control of carrier proteins. Although "free" forms of oligosaccharides (fOSs) are known to be accumulated in the cytosol, the precise mechanism of their formation, degradation and biological relevance remains poorly ...

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01.10.2011 | Angulo, Iván; Acebrón, Iván; de las Rivas, Blanca; Muñoz, Rosario; Rodríguez-Crespo, I; Menéndez, Margarita; García, ..., Glycobiology , 2011

In this work, we analyzed at high resolution the sugar-binding mode of the recombinant N-terminal ricin-B domain of the hemolytic protein LSLa (LSL150) from the mushroom Laetiporus sulphureus and also provide functional in vitro evidence suggesting that, together with its putative ...

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01.10.2011 | Knirel, Y. A., Kondakova, A. N., Vinogradov, E., Lindner, B., Perepelov, A. V., Shashkov, A. S., Glycobiology , 2011

Bacteria Shigella, the cause of shigellosis, evolved from the intestinal bacteria Escherichia coli. Based on structurally diverse O-specific polysaccharide chains of the lipopolysaccharides (LPSs; O-antigens), three from four Shigella species are subdivided into multiple serotypes. The central ...

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