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Galectin-9 regulates T helper cell function independently of Tim-3

01.10.2011 | Su, E. W., Bi, S., Kane, L. P., Glycobiology , 2011

β-Galactoside-binding lectin 9 (galectin-9) is a tandem repeat-type member of the galectin family. It was initially characterized as an eosinophil chemoattractant and an inducer of apoptosis in thymocytes. Subsequently, galectin-9 was identified as a ligand for transmembrane immunoglobulin mucin ...

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Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii

01.10.2011 | Young, N. M., Kreisman, L. S., Stupak, J., MacLean, L. L., Cobb, B. A., Richards, J. C., Glycobiology , 2011

Morganella morganii is a commensal Gram-negative bacterium that has long been known to produce an antigen bearing phosphocholine groups. We determined the structure of this O-chain antigen and found that its repeating unit also contains a free amino group and a second phosphate: This ...

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Occurrence of the human tumor-specific antigen structure Gal{beta}1-3GalNAc{alpha}- (Thomsen-Friedenreich) and related structures on gut bacteria: Prevalence, immunochemical analysis and structural confirmation

01.10.2011 | Henderson, G., Ulsemer, P., Schober, U., Loffler, A., Alpert, C.-A., Zimmermann-Kordmann, M., Reutter, W., Karsten, ..., Glycobiology , 2011

The Thomsen–Friedenreich antigen (TF; CD176, Galβ1-3GalNAcα-) is a tumor-specific carbohydrate antigen and a promising therapeutic target. Antibodies that react with this antigen are frequently found in the sera of healthy adults and are assumed to play a role in cancer immunosurveillance. In ...

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N-Glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1

01.10.2011 | Zandberg, W. F., Benjannet, S., Hamelin, J., Pinto, B. M., Seidah, N. G., Glycobiology , 2011

The limited proteolysis of proteins by the proprotein convertases (PCs) is a common means of producing bioactive proteins or peptides. The PCs are associated with numerous human pathologies and their activity can be reduced through the use of specific inhibitors. Here, we demonstrate an ...

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The role of decorin and biglycan dermatan sulfate chain(s) in fibrosis-affected fascia

01.10.2011 | Kozma, E. M., Wisowski, G., Kusz, D., Olczyk, K., Glycobiology , 2011

Organ fibrosis is associated with excessive deposition of dermatan sulfate (DS) in the extracellular matrix (ECM) of the affected tissue. However, the significance of DS in fibrosis process is poorly known. Thus, we have analyzed both in vitro and in vivo the binding potential toward fibroblast ...

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Method for milk oligosaccharide profiling by 2-aminobenzamide labeling and hydrophilic interaction chromatography

01.10.2011 | Marino, K., Lane, J. A., Abrahams, J. L., Struwe, W. B., Harvey, D. J., Marotta, M., Hickey, R. M., Rudd, P. M., Glycobiology , 2011

Although the properties of milk oligosaccharides have been of scientific interest for many years, their structural diversity presents a challenging analytical task. In the quest for a simple and robust technology to characterize the different oligosaccharides present in milk, we developed an ...

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Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog

01.10.2011 | Otto, Nigel J; Solakyildirim, Kemal; Linhardt, Robert J; DeAngelis, Paul L, Glycobiology , 2011

Glycosaminoglycans (GAGs) are linear hexosamine-containing polysaccharides. These polysaccharides are synthesized by some pathogenic bacteria to form an extracellular coating or capsule. This strategy forms the basis of molecular camouflage since vertebrates possess naturally occurring GAGs that ...

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Metabolism of free oligosaccharides is facilitated in the och1{Delta} mutant of Saccharomyces cerevisiae

01.10.2011 | Hirayama, H., Suzuki, T., Glycobiology , 2011

In eukaryotic cells, it is known that N-glycans play a pivotal role in quality control of carrier proteins. Although "free" forms of oligosaccharides (fOSs) are known to be accumulated in the cytosol, the precise mechanism of their formation, degradation and biological relevance remains poorly ...

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High-resolution structural insights on the sugar-recognition and fusion tag properties of a versatile {beta}-trefoil lectin domain from the mushroom Laetiporus sulphureus

01.10.2011 | Angulo, Iván; Acebrón, Iván; de las Rivas, Blanca; Muñoz, Rosario; Rodríguez-Crespo, I; Menéndez, Margarita; García, ..., Glycobiology , 2011

In this work, we analyzed at high resolution the sugar-binding mode of the recombinant N-terminal ricin-B domain of the hemolytic protein LSLa (LSL150) from the mushroom Laetiporus sulphureus and also provide functional in vitro evidence suggesting that, together with its putative ...

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Lipopolysaccharide core structures and their correlation with genetic groupings of Shigella strains. A novel core variant in Shigella boydii type 16

01.10.2011 | Knirel, Y. A., Kondakova, A. N., Vinogradov, E., Lindner, B., Perepelov, A. V., Shashkov, A. S., Glycobiology , 2011

Bacteria Shigella, the cause of shigellosis, evolved from the intestinal bacteria Escherichia coli. Based on structurally diverse O-specific polysaccharide chains of the lipopolysaccharides (LPSs; O-antigens), three from four Shigella species are subdivided into multiple serotypes. The central ...

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