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Response to 'Evolving M-protein pattern in patients with smoldering multiple myeloma: impact on early progression'

25.05.2018 | Arjun Lakshman; Praful Ravi; S. Vincent Rajkumar; Shaji K. Kumar, Leukemia, 2018

Response to 'Evolving M-protein pattern in patients with smoldering multiple myeloma: impact on early progression' Response to 'Evolving M-protein pattern in patients with smoldering multiple myeloma: impact on early progression', Published online: 25 May 2018; ...

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Coppery inks paint an underwater rainbow

25.05.2018 | Nature, 2018

Coppery inks paint an underwater rainbow Coppery inks paint an underwater rainbow, Published online: 25 May 2018; doi:10.1038/d41586-018-05282-y Inexpensive version of luminescent pigment shrugs off water.

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Genome-wide distribution of linker histone H1.0 is independent of MeCP2

25.05.2018 | Aya Ito-Ishida; Hari Krishna Yamalanchili; Yingyao Shao; Steven A. Baker; Laura D. Heckman; Laura A. Lavery; Ji-yoen ..., Nature Neuroscience, 2018

Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 ...

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Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential

25.05.2018 | David J. H. F. Knapp; Colin A. Hammond; Tony Hui; Marijn T. J. Loenhout; Fangwu Wang; Nima Aghaeepour; Paul H. Mille ..., Nature Cell Biology, 2018

Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested in cells identified uniquely by their ability to clonally regenerate detectable, albeit ...

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IDO expression in breast cancer: an assessment of 281 primary and metastatic cases with comparison to PD-L1

25.05.2018 | Erik A. Dill; Patrick M. Dillon; Timothy N. Bullock; Anne M. Mills, Modern Pathology, 2018

The immune inhibitory enzyme indoleamine 2,3-dioxygenase (IDO) has been associated with immune evasion in numerous malignancies and may mark these cancers as susceptible to anti-IDO therapies. We herein address IDO expression in breast cancers, examine the relationship between IDO and PD-L1, and ...

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A randomized controlled trial: does coaching using video during direct laryngoscopy improve residents’ success in neonatal intubations?

25.05.2018 | Sarah Volz; Timothy P. Stevens; Rita Dadiz, Journal of Perinatology, 2018

To evaluate the intubation success rates of residents who receive coaching from supervisors concurrently viewing infants’ airways via video during direct laryngoscopy (VDL), as compared with coaching during traditional direct laryngoscopy without video (TDL). In a randomized controlled trial, 48 ...

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Protein quality and miRNA slicing get into phase

25.05.2018 | Tanja Mittag; Nicolas L. Fawzi, Nature Cell Biology, 2018

Protein quality and miRNA slicing get into phase Protein quality and miRNA slicing get into phase, Published online: 25 May 2018; doi:10.1038/s41556-018-0113-4 Phase separation can build assemblies and regulate biological function. Two articles link specific forms of protein and RNA degradation ...

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Publisher Correction: View from... MTSA 2017/Tera Nano 8/Opto X Nano: Terahertz surprises

25.05.2018 | Noriaki Horiuchi, Nature Photonics, 2018

Publisher Correction: View from... MTSA 2017/Tera Nano 8/Opto X Nano: Terahertz surprises Publisher Correction: View from... MTSA 2017/Tera Nano 8/Opto X Nano: Terahertz surprises, Published online: 25 May 2018; doi:10.1038/s41566-018-0197-1 Publisher Correction: View from... MTSA 2017/Tera Nano ...

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Rett syndrome: a seminal book on extensive multidisciplinary analyses for rare disease

25.05.2018 | Pierre Bitoun, European Journal of Human Genetics, 2018

Rett syndrome: a seminal book on extensive multidisciplinary analyses for rare disease Rett syndrome: a seminal book on extensive multidisciplinary analyses for rare disease, Published online: 25 May 2018; doi:10.1038/s41431-018-0163-x Rett syndrome: a seminal book on extensive multidisciplinary ...

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Low risk of lymph node metastasis in 495 early gastric cardiac carcinomas: a multicenter clinicopathologic study of 2101 radical gastrectomies for early gastric carcinoma

25.05.2018 | Qin Huang; Yuqing Cheng; Ling Chen; Du Mingzhan; Yaohui Wang; Guifang Xu; Jiong Shi; Xiangshan Fan; Xiaoli Zhou; Yif ..., Modern Pathology, 2018

Clinical decision-making on endoscopic vs. surgical resection of early gastric cardiac carcinoma remains challenging because of uncertainty on risk of lymph node metastasis. The aim of this multicenter study was to investigate risk factors of lymph node metastasis in early gastric cardiac ...

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