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23.852 Aktuelle Fachpublikationen von john-wiley-sons

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Down‐regulation of gephyrin in temporal lobe epilepsy neurons in humans and a rat model

01.10.2011 | Min Fang; Lan Shen; huan Yin; Yu‐Min Pan; Liang Wang; Dan Chen; Zhi‐Qin Xi; Zheng Xiao; Xue‐Feng Wang; Huan Yin; She ..., Synapse, 2011

Abstract Gephyrin, which is a postsynaptic scaffolding protein participated in clustering GABAA receptors at inhibitory synapses, has been reported to be involved in temporal lobe epilepsy (TLE) recently. Here, we investigate gephyrin protein expression in the temporal lobe epileptic foci in ...

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Inhibition of 3,4‐methylenedioxymethamphetamine (MDMA) metabolism leads to marked decrease in 3,4‐dihydroxymethamphetamine (HHMA) formation but no change in serotonin neurotoxicity: Implications for mechanisms of neurotoxicity

01.10.2011 | Melanie Mueller; Jie Yuan; Concepcion Maldonado Adrian; Una D. McCann; George A. Ricaurte; Una D. Mccann, Synapse, 2011

Abstract 3,4‐Methylenedioxymethamphetamine (MDMA)'s O‐demethylenated metabolite, 3,4‐dihydroxymethamphetamine (HHMA), has been hypothesized to serve as a precursor for the formation of toxic catechol thioether metabolites (e.g. 5‐N‐acetylcystein‐S‐yl‐HHMA) that mediate ...

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Arginine controls heat‐induced cluster–cluster aggregation of lysozyme at around the isoelectric point

01.10.2011 | Shunsuke Tomita; Hiroki Yoshikawa; Kentaro Shiraki, Biopolymers, 2011

Abstract The process of protein aggregation has attracted a great deal of research attention, as aggregates are first of all a nuisance to preparation of high quality protein and secondly used as novel materials. In the latter case, the process of protein aggregation needs to be controlled. ...

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Chronic stress and antidepressant agomelatine induce region‐specific changes in synapsin I expression in the rat brain

01.10.2011 | Girstaute Dagyte; Paul G. Luiten; Tim De Jager; Cecilia Gabriel; Elisabeth Mocaër; Johan A. Den Boer; Eddy A. Van de ..., Journal of Neuroscience Research, 2011

Abstract The antidepressant agomelatine acts as a melatonergic receptor (MT1/MT2) agonist and 5‐HT2C receptor antagonist. Agomelatine has demonstrated efficacy in treating depression, but its neurobiological effects merit further investigation. Preclinical studies reported that agomelatine ...

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Slit‐Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain

01.10.2011 | Itzel Ricaño‐Cornejo; Amy L. Altick; Claudia M. García‐Peña; Hikmet Feyza Nural; Diego Echevarría; Amaya Miquelajáur ..., Journal of Neuroscience Research, 2011

Abstract During early vertebrate forebrain development, pioneer axons establish a symmetrical scaffold descending longitudinally through the rostral forebrain, thus forming the tract of the postoptic commissure (TPOC). In mouse embryos, this tract begins to appear at embryonic day 9.5 (E9.5) as ...

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Lithium protects against oxidative stress‐mediated cell death in α‐synuclein‐overexpressing in vitro and in vivo models of Parkinson's disease

01.10.2011 | Yong‐Hwan Kim; Anand Rane; Stephanie Lussier; Julie K. Andersen, Journal of Neuroscience Research, 2011

Abstract Lithium has recently been suggested to have neuroprotective properties in relation to several neurodegenerative diseases. In this study, we examined the potential cytoprotective effect of lithium in preventing oxidative stress‐induced protein accumulation and neuronal cell death in the ...

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Protective effect of thalidomide against N‐methyl‐D‐aspartate‐induced retinal neurotoxicity

01.10.2011 | Kazuhide Takada; Yasunari Munemasa; Junko Kuribayashi; Hiromi Fujino; Yasushi Kitaoka, Journal of Neuroscience Research, 2011

Abstract Thalidomide, an inhibitor of tumor necrosis factor‐α (TNF‐α) production, has been indicated to be useful for many inflammatory and oncogenic diseases. In the present study, we examined whether thalidomide (50 mg/kg/day, p.o.) has a protective effect against N‐methyl‐D‐aspartate ...

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Lopinavir/ritonavir resistance in patients infected with HIV‐1: two divergent resistance pathways?

01.10.2011 | Karen Champenois; Agathe Baras; Philippe Choisy; Faiza Ajana; Hughes Melliez; Laurence Bocket; Yazdan Yazdanpanah, Journal of Medical Virology, 2011

Abstract The HIV‐1 protease L76V mutation has been described recently as conferring high‐level resistance to lopinavir/ritonavir (LPV/r). The aim was to identify the factors and particularly protease mutations associated with the presence of L76V in treatment‐experienced patients infected with ...

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Co‐circulation HIV‐1 subtypes B, C, and CRF31_BC in a drug‐naïve population from Southernmost Brazil: Analysis of primary resistance mutations

01.10.2011 | Rúbia Marília de Medeiros; Dennis Maletich Junqueira; Maria Cristina Cotta Matte; Nêmora Tregnago Barcellos; José Ar ..., Journal of Medical Virology, 2011

Abstract In Southernmost Brazil HIV‐1 subtypes B, C, and CRF31_BC co‐circulates and, since 1996 with the implementation of free access to highly active antiretroviral treatment (HAART), this epidemic is under a quite characteristic selective pressure. The profile of mutations and polymorphisms ...

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Treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus‐8 replication in HIV‐1 seropositive men

01.10.2011 | Ashok Cattamanchi; Misty Saracino; Stacy Selke; Meei‐Li Huang; Amalia Magaret; Connie Celum; Lawrence Corey; Anna Wa ..., Journal of Medical Virology, 2011

Abstract Human herpesvirus‐8 (HHV‐8) replication is a key factor in Kaposi sarcoma, primary effusion lymphoma, and Castleman disease pathogenesis. In vitro data suggest that antivirals inhibit HHV‐8 replication, but little data exist in humans. Daily oropharyngeal swabs were analyzed from ...

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