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Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders

11.02.2015 | Adomas Bunevicius; Giorgio Iervasi; Robertas Bunevicius, Expert Review of Neurotherapeutics, 2015

Acute cerebrovascular disorders are common causes of death and disability worldwide. Prognostication of stroke victims rests mainly on admission clinical and radiological indexes of disease severity. Preclinical studies strongly suggest that thyroid hormones have a capacity to exert ...

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A Bayesian sensitivity study of risk difference in the meta-analysis of binary outcomes from sparse data

11.02.2015 | Francisco-Jose Vázquez-Polo; Elías Moreno; Miguel A Negrín; Maria Martel, Expert Review of Pharmacoeconomics & Outcomes Research, 2015

In most cases, including those of discrete random variables, statistical meta-analysis is carried out using the normal random effect model. The authors argue that normal approximation does not always properly reflect the underlying uncertainty of the original discrete data. Furthermore, in the ...

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Alternative transarterial access for CoreValve transcatheter aortic bioprosthesis implantation

11.02.2015 | Giuseppe Bruschi; Federico De Marco; Thomas Modine; Luca Botta; Paola Colombo; Silvia Mauri; Aldo Cannata; Pasquale ..., Expert Review of Medical Devices, 2015

Transcatheter aortic valve implantation (TAVI) is used to treat elderly patients with severe aortic stenosis who are considered extremely high-risk surgical candidates. The safety and effectiveness of TAVI have been demonstrated in numerous studies. The self-expanding CoreValve bioprosthesis ...

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Tofacitinib for the treatment of moderate-to-severe psoriasis

10.02.2015 | Andrea Chiricozzi; Sara Faleri; Rosita Saraceno; Luca Bianchi; Oreste Buonomo; Sergio Chimenti; Maria Sole Chimenti, Expert Review of Molecular Diagnostics, 2015

Because of the increased knowledge about the underlying cytokine network in psoriasis, selective systemic agents for the treatment of moderate-to-severe psoriasis have been developed during the past decade. The marked upregulation of JAK/STAT pathways in psoriasis and the identification of ...

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Type 1 reaction in leprosy: a model for a better understanding of tissue immunity under an immunopathological condition

10.02.2015 | Priscila Ribeiro Andrade; Roberta Olmo Pinheiro; Anna Maria Sales; Ximena Illarramendi; Mayara Garcia de Mattos Barb ..., Expert Review of Molecular Diagnostics, 2015

Type 1 reaction (T1R) or reversal reaction is the leading cause of physical disabilities and deformities in leprosy. Leprosy patients, even after being considered cured and released from treatment, may suffer from reactional episodes for long periods of time. Early diagnosis is a great challenge ...

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Fish-allergic patients may be able to eat fish

10.02.2015 | Ahmad A Mourad; Sami L Bahna, Expert Review of Molecular Diagnostics, 2015

Reported fish allergy prevalence varies widely, with an estimated prevalence of 0.2% in the general population. Sensitization to fish can occur by ingestion, skin contact or inhalation. The manifestations can be IgE or non-IgE mediated. Several fish allergens have been identified, with ...

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Recombinant human C1 esterase inhibitor for the treatment of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE)

10.02.2015 | Geetika Sabharwal; Timothy Craig, Expert Review of Molecular Diagnostics, 2015

The lack of C1 inhibitor function that results in excessive production of bradykinin causing the angioedema seen in hereditary angioedema (HAE) is well established. Several drugs have been developed to treat and prevent attacks in patients suffering from HAE due to C1 inhibitor deficiency ...

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The potential of induced pluripotent stem cells in models of neurological disorders: implications on future therapy

09.02.2015 | Jeremy Micah Crook; Gordon Wallace; Eva Tomaskovic-Crook, Expert Review of Neurotherapeutics, 2015

There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last ...

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Progress in the treatment of small fiber peripheral neuropathy

09.02.2015 | Ming-Chang Chiang; Ming-Tsung Tseng; Chun-Liang Pan; Chi-Chao Chao; Sung-Tsang Hsieh, Expert Review of Neurotherapeutics, 2015

Small fiber neuropathy is a syndrome of diverse disease etiology because of multiple pathophysiologic mechanisms with major presentations of neuropathic pain and autonomic symptoms. Over the past decade, there has been substantial progress in the treatments for neuropathic pain, dysautonomia and ...

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Cost-effective treatment modalities for reducing morbidity associated with chronic kidney disease

08.02.2015 | Thomas W Ferguson; Navdeep Tangri; Claudio Rigatto; Paul Komenda, Expert Review of Pharmacoeconomics & Outcomes Research, 2015

Chronic kidney disease (CKD) is a worldwide health problem with increasing prevalence and incidence. Guidelines suggest that early referral to a nephrologist to manage advanced stage (4+) patients with CKD is an effective treatment strategy, with earlier stage patients best managed through ...

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