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Complexes formed by mutant p53 and their roles in breast cancer

18.06.2018 | Breast Cancer: Targets and Therapy, 2018

Breast cancer is the most frequently diagnosed malignancy in women, and mutations in the tumor suppressor p53 are commonly detected in the most aggressive subtypes. The majority of TP53 gene alterations are missense substitutions, leading to expression of mutant forms of the p53 protein that are ...


Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients

15.05.2017 | OncoTargets and Therapy, 2017

Despite a series of attempts during the last decades, the prognosis of esophageal squamous cell carcinoma (ESCC) remains poor. Different responses of individual tumors encouraged us to look for valuable prognostic markers. As a key regulator controlling the anabolic ketogenic pathway, ...


An isolated unusual digit metastasis from esophageal carcinoma: a case report

09.05.2017 | OncoTargets and Therapy, 2017

Distant soft tissue tumor metastasis isolated in the digit, presenting as a primary esophageal squamous cell carcinoma is considered extremely rare. Herein, we present a rare case of a 44-year-old male patient with squamous cell carcinoma of the esophagus associated with the clinical symptoms of ...


Mucoactive and antioxidant medicines for COPD: consensus of a group of Chinese pulmonary physicians

22.03.2017 | International Journal of COPD, 2017

Airway mucus hypersecretion is a frequent symptom associated with acute and chronic airway disease. Inhibition of mucus production or promotion of mucolysis not only relieved symptoms but also improved disease outcomes. There are numerous available mucoactive medicines for prescription, and how ...


Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD

20.02.2017 | International Journal of COPD, 2017

Skeletal muscle atrophy and dysfunction are common complications in the chronic obstructive pulmonary disease (COPD). However, the underlying molecular mechanism remains elusive. Serum response factor (SRF) is a transcription factor which is critical in myocyte differentiation and growth. In this ...


Efficacy of tiotropium–olodaterol fixed-dose combination in COPD

13.12.2016 | International Journal of COPD, 2016

Tiotropium–olodaterol, formulated in the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting β2-agonist (LABA), commercialized under the name of Spiolto or Stiolto. The efficacy of tiotropium–olodaterol 5–5 µg once ...


Advances in the management of erythropoietic protoporphyria – role of afamelanotide

12.12.2016 | The Application of Clinical Genetics, 2016

Erythropoietic protoporphyria (EPP) and the phenotypically similar disease X-linked protoporphyria (XLPP) are inherited cutaneous porphyrias characterized clinically by acute non-blistering photosensitivity, intolerance to sunlight, and significantly reduced quality of life. They are due to ...


MLL1 promotes cervical carcinoma cell tumorigenesis and metastasis through interaction with β-catenin

28.10.2016 | OncoTargets and Therapy, 2016

MLL protein genes encode a family of crucial transcription factors that play a key role in multiple cancer development. The functions of different MLL proteins have not been definitively studied. MLL1 is a histone methyltransferase that mediates histone H3 lysine 4, and it has been found to have ...


Genetic basis of Cowden syndrome and its implications for clinical practice and risk management

13.07.2016 | The Application of Clinical Genetics, 2016

Cowden syndrome (CS) is an often difficult to recognize hereditary cancer predisposition syndrome caused by mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN). In addition to conferring increased cancer risks, CS also predisposes individuals to developing hamartomatous ...


Transcription factor activity of estrogen receptor α activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells

13.06.2016 | OncoTargets and Therapy, 2016

Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptor α (ERα) and therefore induce potential disruption of normal endocrine function. However, the involvement of EDCs in human ...


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