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13.733 Aktuelle Fachpublikationen von American Chemical Society Publications

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Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum

17.01.2018 | Dan Yang; Zhong-Quan Cheng; Liu Yang; Bo Hou; Jing Yang; Xiao-Nian Li; Cheng-Ting Zi; Fa-Wu Dong; Zheng-Hua Liu; Jun ..., Journal of Natural Products, 2018

Investigation of the 95% EtOH extract of stems of Dendrobium findlayanum afforded four new seco-dendrobines, findlayines A–D (1–4); two known dendrobines, dendrobine (5) and 2-hydroxydendrobine (6); and four new phenolic compounds, dendrofindlaphenols A–C (7, 9, and 10) and ...

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Protein Inhibitors of CRISPR-Cas9

17.01.2018 | Joseph Bondy-Denomy, ACS Chemical Biology, 2018

Bacteria are under constant predation from viruses, called bacteriophages (phages). This threat has driven the evolution of multiple defense systems, including the CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR associated genes) immune pathway. Phages are not ...

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Prenylated 2-Phenoxychromones and Flavonoids from Epimedium brevicornum and Revised Structures of Epimedonins A and B

17.01.2018 | Fu-Cai Ren; Xian-Jun Jiang; Shi-Zhen Wen; Li-Xia Wang; Xiang-Mei Li; Fei Wang, Journal of Natural Products, 2018

Six hitherto unknown prenylated 2-phenoxychromones, epimedonin G (1), 7-O-methylepimedonin G (2), and epimedonins H–K (3–6), and two new prenylflavonoids, epimedonin L (7) and 3″-O-desmethylspinorhamnoside (8), were isolated from an ethanol extract of the aerial parts of Epimedium brevicornum. ...

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Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

17.01.2018 | Isabel Aparici-Espert; Guillermo Garcia-Lainez; Inmaculada Andreu; Miguel Angel Miranda; Virginie Lhiaubet-Vallet, ACS Chemical Biology, 2018

In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced light absorption in the UVB–UVA region. The mechanistic study combining ...

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Evaluation of the Active Targeting of Melanin Granules after Intravenous Injection of Dendronized Nanoparticles

17.01.2018 | C. Bordeianu; A. Parat; S. Piant; A. Walter; C. Zbaraszczuk-Affolter; F. Meyer; S. Begin-Colin; S. Boutry; R. N. Mul ..., Molecular Pharmaceutics, 2018

The biodistribution of dendronized iron oxides, NPs10@D1_DOTAGA and melanin-targeting NPs10@D1_ICF_DOTAGA, was studied in vivo using magnetic resonance imaging (MRI) and planar scintigraphy through [177Lu]Lu-radiolabeling. MRI experiments showed high contrast power of both dendronized ...

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Millisecond Self-Assembly of Stable Nanodispersed Drug Formulations

17.01.2018 | Vikram J. Pansare; Aditya Rawal; Aaron Goodwin; Ron Beyerinck; Robert K. Prud’homme; Dwayne T. Friesen; Michael Gras ..., Molecular Pharmaceutics, 2018

We report the development of a new spray-drying and nanoparticle assembly process (SNAP) that enables the formation of stable, yet rapidly dissolving, sub-200 nm nanocrystalline particles within a high Tg glassy matrix. SNAP expands the class of drugs that spray-dried dispersion (SDD) processing ...

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Targeted Drug Delivery and Treatment of Endoparasites with Biocompatible Particles of pH-Responsive Structure

17.01.2018 | Patrick D. Mathews; Ana C. M. Fernandes Patta; Joao V. Gonçalves; Gabriella dos Santos Gama; Irene Teresinha Santos ..., Biomacromolecules, 2018

Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via ...

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Comparison of the Expression Kinetics and Immunostimulatory Activity of Replicating mRNA, Nonreplicating mRNA, and pDNA after Intradermal Electroporation in Pigs

17.01.2018 | Bregje Leyman; Hanne Huysmans; Séan Mc Cafferty; Francis Combes; Eric Cox; Bert Devriendt; Niek N. Sanders, Molecular Pharmaceutics, 2018

Synthetic mRNA is becoming increasingly popular as an alternative to pDNA-based gene therapy. Currently, multiple synthetic mRNA platforms have been developed. In this study we investigated the expression kinetics and the changes in mRNA encoding cytokine and chemokine levels following ...

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Influence of Poly(styrene-co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs

16.01.2018 | Stephen C. L. Hall; Cecilia Tognoloni; Gareth J. Price; Bert Klumperman; Karen J. Edler; Tim R. Dafforn; Thomas Arnold, Biomacromolecules, 2018

Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that wraps around a segment of lipid bilayer, and as such are capable of encapsulating membrane proteins directly from the cell membrane. To date, most studies on these nanodiscs have used poly(styrene-co-maleic ...

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A d-Peptide Ligand of Integrins for Simultaneously Targeting Angiogenic Blood Vasculature and Glioma Cells

16.01.2018 | Yachao Ren; Changyou Zhan; Jie Gao; Mingfei Zhang; Xiaoli Wei; Man Ying; Zining Liu; Weiyue Lu, Molecular Pharmaceutics, 2018

The current prognosis of glioma patients remains poor after intensive multimodal treatments, which is partially due to the existence of the blood–brain tumor barrier (BBTB). In the present study, a novel “bifunctional ligand” (termed DVS) was developed by retro-inverso isomerization. DVS is a ...

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