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3.269 Aktuelle Fachpublikationen von AACR Publications

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Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21

01.07.2011 | Tsuchiya, N., Izumiya, M., Ogata-Kawata, H., Okamoto, K., Fujiwara, Y., Nakai, M., Okabe, A., Schetter, A. J., Bowma ..., Cancer Research, 2011

Selective activation of p53 target genes in response to various cellular stresses is a critical step in determining the ability to induce cell-cycle arrest or apoptosis. Here we report the identification of the microRNA miR-22 as a p53 target gene that selectively determines the induction of ...

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HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

01.07.2011 | Mathieu, J., Zhang, Z., Zhou, W., Wang, A. J., Heddleston, J. M., Pinna, C. M. A., Hubaud, A., Stadler, B., Choi, M. ..., Cancer Research, 2011

Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression signatures characteristic of human embryonic ...

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Targeted Methylation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells

01.07.2011 | Teng, I.-W., Hou, P.-C., Lee, K.-D., Chu, P.-Y., Yeh, K.-T., Jin, V. X., Tseng, M.-J., Tsai, S.-J., Chang, Y.-S., Wu ..., Cancer Research, 2011

Although DNA hypermethylation within promoter CpG islands is highly correlated with tumorigenesis, it has not been established whether DNA hypermethylation within a specific tumor suppressor gene (TSG) is sufficient to fully transform a somatic stem cell. In this study, we addressed this question ...

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c-Myc Regulates RNA Splicing of the A-Raf Kinase and Its Activation of the ERK Pathway

01.07.2011 | Rauch, J., Moran-Jones, K., Albrecht, V., Schwarzl, T., Hunter, K., Gires, O., Kolch, W., Cancer Research, 2011

A-Raf kinase can inhibit apoptosis by binding to the proapoptotic mammalian sterile 20-like kinase (MST2). This function relies on expression of hnRNP H, which ensures the correct splicing of a-raf mRNA needed to produce full-length A-Raf protein. Here, we showed that expression of hnRNP H and ...

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Perinatal or Adult Nf1 Inactivation Using Tamoxifen-Inducible PlpCre Each Cause Neurofibroma Formation

01.07.2011 | Mayes, D. A., Rizvi, T. A., Cancelas, J. A., Kolasinski, N. T., Ciraolo, G. M., Stemmer-Rachamimov, A. O., Ratner, N., Cancer Research, 2011

Plexiform neurofibromas are peripheral nerve sheath tumors initiated by biallelic mutation of the NF1 tumor suppressor gene in the Schwann cell lineage. To understand whether neurofibroma formation is possible after birth, we induced Nf1 loss of function with an inducible proteolipid protein Cre ...

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Susceptible Stages in Schwann Cells for NF1-Associated Plexiform Neurofibroma Development

01.07.2011 | Le, L. Q., Liu, C., Shipman, T., Chen, Z., Suter, U., Parada, L. F., Cancer Research, 2011

Stem cells are under strict regulation by both intrinsic factors and the microenvironment. There is increasing evidence that many cancers initiate through acquisition of genetic mutations (loss of intrinsic control) in stem cells or their progenitors, followed by alterations of the surrounding ...

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Stromal Niche Cells Protect Early Leukemic FLT3-ITD+ Progenitor Cells against First-Generation FLT3 Tyrosine Kinase Inhibitors

01.07.2011 | Parmar, A., Marz, S., Rushton, S., Holzwarth, C., Lind, K., Kayser, S., Dohner, K., Peschel, C., Oostendorp, R. A. J ..., Cancer Research, 2011

Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem ...

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TGF{beta}/TNF{alpha}-Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

01.07.2011 | Asiedu, M. K., Ingle, J. N., Behrens, M. D., Radisky, D. C., Knutson, K. L., Cancer Research, 2011

Breast cancer recurrence is believed to be caused by a subpopulation of cancer cells that possess the stem cell attribute of treatment resistance. Recently, we and others have reported the generation of breast cancer stem cells (BCSC) by epithelial–mesenchymal transition (EMT), although the ...

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Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation

01.07.2011 | Polytarchou, C., Iliopoulos, D., Hatziapostolou, M., Kottakis, F., Maroulakou, I., Struhl, K., Tsichlis, P. N., Cancer Research, 2011

The growth and survival of tumor cells in an unfavorable hypoxic environment depend upon their adaptability. Here, we show that both normal and tumor cells expressing the protein kinase Akt2 are more resistant to hypoxia than cells expressing Akt1 or Akt3. This is due to the differential ...

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