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Correction: Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer

15.05.2017 | American Association for Cancer Research, Cancer Research, 2017

In this article [(Cancer Res 2015;75:3738–46)][1], which appeared in the September 15, 2015, issue of Cancer Research ([1][2]), Sunil R. Hingorani and Amy Chang have been added as the 10th and 11th authors. The correct author listing is as follows: Tong Li, Yak-Nam Wang, Tatiana D. Khokhlova,


Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy

15.05.2017 | Demin Li; Carol Bentley; Amanda Anderson; Sarah Wiblin; Kirstie L.S. Cleary; Sofia Koustoulidou; Tasneem Hassanali; ..., Cancer Research, 2017

The tumor suppressor p53 is widely dysregulated in cancer and represents an attractive target for immunotherapy. Because of its intracellular localization, p53 is inaccessible to classical therapeutic monoclonal antibodies, an increasingly successful class of anticancer drugs. However, peptides ...


A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

01.05.2017 | Alexis A. Kurmis; Fei Yang; Timothy R. Welch; Nicholas G. Nickols; Peter B. Dervan, Cancer Research, 2017

The LREX' prostate cancer model is resistant to the antiandrogen enzalutamide via activation of an alternative nuclear hormone receptor, glucocorticoid receptor (GR), which has similar DNA-binding specificity to the androgen receptor (AR). Small molecules that target DNA to interfere with ...


Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression

01.05.2017 | Hirotake Tsukamoto; Koji Fujieda; Masatoshi Hirayama; Tokunori Ikeda; Akira Yuno; Keiko Matsumura; Daiki Fukuma; Kim ..., Cancer Research, 2017

IL6 produced by tumor cells promotes their survival, conferring a poor prognosis in patients with cancer. IL6 also contributes to immunosuppression of CD4+ T cell–mediated antitumor effects. In this study, we focused on the impact of IL6 trans-signaling mediated by soluble IL6 receptors (sIL6R) ...


Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

01.05.2017 | Jingshan Tong; Peng Wang; Shuai Tan; Dongshi Chen; Zaneta Nikolovska-Coleska; Fangdong Zou; Jian Yu; Lin Zhang, Cancer Research, 2017

The Bcl-2 family protein Mcl-1 is often degraded in cancer cells subjected to effective therapeutic treatment, and defective Mcl-1 degradation has been associated with intrinsic and acquired drug resistance. However, a causal relationship between Mcl-1 degradation and anticancer drug responses ...


Regulatory Aspects of Optical Methods and Exogenous Targets for Cancer Detection

01.05.2017 | Willemieke S. Tummers; Jason M. Warram; Kiranya E. Tipirneni; John Fengler; Paula Jacobs; Lalitha Shankar; Lori Hend ..., Cancer Research, 2017

Considerable advances in cancer-specific optical imaging have improved the precision of tumor resection. In comparison to traditional imaging modalities, this technology is unique in its ability to provide real-time feedback to the operating surgeon. Given the significant clinical implications of ...


Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis

01.05.2017 | Kuei-Yang Hsiao; Ya-Chi Lin; Sachin Kumar Gupta; Ning Chang; Laising Yen; H. Sunny Sun; Shaw-Jenq Tsai, Cancer Research, 2017

Circular RNA (circRNA) is a class of noncoding RNA whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence is scarce. Here, we characterize the functional role of a novel circRNA, circCCDC66, in colorectal cancer. RNA-Seq ...


Role of CBX4 in the Colorectal Carcinoma Metastasis—Letter

01.05.2017 | Valentina Sancisi; Alessia Ciarrocchi, Cancer Research, 2017

The study by Wang and colleagues showed that CBX4 suppresses colon cancer metastasis by repressing the expression of RUNX2 . They also demonstrated that CBX4 recruits HDAC3 on the RUNX2 promoter, leading to inhibition of its expression ([1][1]). RUNX2 is a transcription factor, important for


Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma

01.05.2017 | Zhihong Chen; Xi Feng; Cameron J. Herting; Virginia Alvarez Garcia; Kai Nie; Winnie W. Pong; Rikke Rasmussen; Bhakti ..., Cancer Research, 2017

In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TAM composition during gliomagenesis, we used ...


Whither Radioimmunotherapy: To Be or Not To Be?

01.05.2017 | Damian J. Green; Oliver W. Press, Cancer Research, 2017

Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two “first-generation,” directly radiolabeled anti-CD20 antibodies, ...


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