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3.269 Aktuelle Fachpublikationen von AACR Publicationsrss
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15.05.2017 | American Association for Cancer Research, Cancer Research, 2017
In this article [(Cancer Res 2015;75:3738–46)], which appeared in the September 15, 2015, issue of Cancer Research (), Sunil R. Hingorani and Amy Chang have been added as the 10th and 11th authors. The correct author listing is as follows: Tong Li, Yak-Nam Wang, Tatiana D. Khokhlova,
15.05.2017 | Demin Li; Carol Bentley; Amanda Anderson; Sarah Wiblin; Kirstie L.S. Cleary; Sofia Koustoulidou; Tasneem Hassanali; ..., Cancer Research, 2017
The tumor suppressor p53 is widely dysregulated in cancer and represents an attractive target for immunotherapy. Because of its intracellular localization, p53 is inaccessible to classical therapeutic monoclonal antibodies, an increasingly successful class of anticancer drugs. However, peptides ...
01.05.2017 | Alexis A. Kurmis; Fei Yang; Timothy R. Welch; Nicholas G. Nickols; Peter B. Dervan, Cancer Research, 2017
The LREX' prostate cancer model is resistant to the antiandrogen enzalutamide via activation of an alternative nuclear hormone receptor, glucocorticoid receptor (GR), which has similar DNA-binding specificity to the androgen receptor (AR). Small molecules that target DNA to interfere with ...
01.05.2017 | Hirotake Tsukamoto; Koji Fujieda; Masatoshi Hirayama; Tokunori Ikeda; Akira Yuno; Keiko Matsumura; Daiki Fukuma; Kim ..., Cancer Research, 2017
IL6 produced by tumor cells promotes their survival, conferring a poor prognosis in patients with cancer. IL6 also contributes to immunosuppression of CD4+ T cell–mediated antitumor effects. In this study, we focused on the impact of IL6 trans-signaling mediated by soluble IL6 receptors (sIL6R) ...
01.05.2017 | Jingshan Tong; Peng Wang; Shuai Tan; Dongshi Chen; Zaneta Nikolovska-Coleska; Fangdong Zou; Jian Yu; Lin Zhang, Cancer Research, 2017
The Bcl-2 family protein Mcl-1 is often degraded in cancer cells subjected to effective therapeutic treatment, and defective Mcl-1 degradation has been associated with intrinsic and acquired drug resistance. However, a causal relationship between Mcl-1 degradation and anticancer drug responses ...
01.05.2017 | Willemieke S. Tummers; Jason M. Warram; Kiranya E. Tipirneni; John Fengler; Paula Jacobs; Lalitha Shankar; Lori Hend ..., Cancer Research, 2017
Considerable advances in cancer-specific optical imaging have improved the precision of tumor resection. In comparison to traditional imaging modalities, this technology is unique in its ability to provide real-time feedback to the operating surgeon. Given the significant clinical implications of ...
01.05.2017 | Kuei-Yang Hsiao; Ya-Chi Lin; Sachin Kumar Gupta; Ning Chang; Laising Yen; H. Sunny Sun; Shaw-Jenq Tsai, Cancer Research, 2017
Circular RNA (circRNA) is a class of noncoding RNA whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence is scarce. Here, we characterize the functional role of a novel circRNA, circCCDC66, in colorectal cancer. RNA-Seq ...
01.05.2017 | Valentina Sancisi; Alessia Ciarrocchi, Cancer Research, 2017
The study by Wang and colleagues showed that CBX4 suppresses colon cancer metastasis by repressing the expression of RUNX2 . They also demonstrated that CBX4 recruits HDAC3 on the RUNX2 promoter, leading to inhibition of its expression (). RUNX2 is a transcription factor, important for
01.05.2017 | Zhihong Chen; Xi Feng; Cameron J. Herting; Virginia Alvarez Garcia; Kai Nie; Winnie W. Pong; Rikke Rasmussen; Bhakti ..., Cancer Research, 2017
In glioblastoma (GBM), tumor-associated macrophages (TAM) represent up to one half of the cells of the tumor mass, including both infiltrating macrophages and resident brain microglia. In an effort to delineate the temporal and spatial dynamics of TAM composition during gliomagenesis, we used ...
01.05.2017 | Damian J. Green; Oliver W. Press, Cancer Research, 2017
Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two “first-generation,” directly radiolabeled anti-CD20 antibodies, ...